The research of oral care for increasing host defense
| Project/Area Number |
15592234
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fundamental nursing
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MICHISHIGE Fumiko The University of Tokushima, School of Medicine, assistant professor, 医学部, 助教授 (00274267)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHINAGA Sumiko The University of Tokushima, School of Medicine, assistant professor, 医学部, 助教授 (30227425)
HINODE Daisuke The University of Tokushima, Institute of Health Biosciences, assistant professor, 大学院・ヘルスバイオサイエンス研究部, 助教授 (70189801)
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| Project Period (FY) |
2003 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2005: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2004: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2003: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | host defence / oral care / salivary secretion / salivary protein / 唾液分泌量 / 生体防御機能 |
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| Research Abstract |
The purpose of this study was investigated how oral care is adequate to increasing host defense for compromised host.
1.Effect of saliva collection method on the concentration of protein components in saliva
In order to clarify how we collect saliva for analyzing salivary protein in aged subjects who can not eat well, we compared the effects of suction, spitting and the swab saliva collection method on the yield of protein components in saliva samples from normal volunteers. The saliva collected by suction, spitting and the swab method were designated as, Saliva I,II and III, respectively.
The saliva volume collected by Saliva I was about 2-fold greater than that by of Saliva II and III. The content of total protein, S-IgA, trypsin-like activity and human airway trypsin-like protease (HAT) were almost the same in Saliva I and II, and significantly lower in Saliva III than in Saliva I and II. Kallikrein activity was almost the same in Saliva I,II and III. The concentration of each total protein, S-IgA, kallikrein activity, trypsin activity and HAT in Saliva I were significantly positively correlated with that in Saliva II.
These results indicate that we can obtain information of change of salivary protein by analyzing saliva collected by suction method, although this method caused the stimulation of saliva to some extent.
2.Salivary flow and composition in elderly patients with enteral nutrition
We compared salivary flow rate and salivary protein in elderly patients with enteral nutrition and by mouth. Salivary flow rate was not different enteral nutrition and by mouth. The content of total protein, S-TgA, trypsin-like activity and human airway trypsin-like protease (HAT) by enteral nutrition were about 2-fold greater than by mouth.
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Report
(4 results)
Research Products
(10 results)
