Functions of BAF complex in DNA repair and cancer therapy
| Project/Area Number |
15H01737
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Tohoku University |
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Principal Investigator |
YASUI Akira 東北大学, 加齢医学研究所, 加齢研フェロー (60191110)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥40,300,000 (Direct Cost: ¥31,000,000、Indirect Cost: ¥9,300,000)
Fiscal Year 2017: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2016: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2015: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
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| Keywords | DNA修復 / ヌクレオゾームリモデリング / BAF複合体 / ARID1A / ARID1B / 細胞癌化 / 細胞老化 / 癌治療 / SWI/SNF / BAF complex / シスプラチン / クロマチンリモデリング / 二重鎖切断 / 発癌 / NHEJ |
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| Outline of Final Research Achievements |
We found that BAF complex belonging to the SWI/SNF family for ATP-dependent chromatin remodeling (nucleosome remodeling) not only contributes to transcriptional regulation but also to DNA repair of various types of DNA damage and identified BAF factors involved in DNA repair. ARID1A and ARID1B, mutually exclusive variant factors for transcription in BAF complex, turned out to interact with KU protein and to contribute to DNA double-strand break repair. Thus, when cell ages, nucleosome remodeling, DNA repair and transcriptional regulation can build a negative feedback loop to promote tumorigenesis and accelerate cellular aging, as DNA repair defect creates mutation influencing NR and TR.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] DNA polymerase beta participates in mitochondrial DNA repair.2017
Author(s)
Sykora P, Kanno S, Akbari M, Kulikowicz T, Baptiste BA, Leandro G, Lu H, Tian J, May A, Becker KA, Croteau DL, Wilson DM III, Sobol RW, Yasui A and Bohr VA.
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Journal Title
Mol Cell Biol.
Volume: on line
Issue: 16
DOI
Related Report
Peer Reviewed
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[Journal Article] ALC1/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair.2017
Author(s)
Tsuda M, Cho K, Ooka M, Shimizu N, Watanabe R, Yasui A, Nakazawa Y, Ogi T, Harada H, Agama K, Nakamura J, Asada R, Fujiike H, Sakuma T, Yamamoto T, Murai J, Hiraoka M, Koike K, Pommier Y, Takeda S, Hirota K.
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Journal Title
PLos One
Volume: 12
Issue: 11
Pages: e0188320-e0188320
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Chromatin remodeling and DNA repair2015
Author(s)
Akira Yasui
Organizer
Nuclear organization for genome stability
Place of Presentation
Osaka, Institutr for Protein Research, Osaka University
Year and Date
2015-05-18
Related Report
Int'l Joint Research / Invited
