| Project/Area Number |
15H01741
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中川 裕之 福岡大学, 理学部, 教授 (80274562)
松島 綾美 九州大学, 理学(系)研究科(研究院), 准教授 (60404050)
劉 暁輝 九州大学, 理学(系)研究科(研究院), 助教 (60596849)
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| Co-Investigator(Renkei-kenkyūsha) |
LIU Xiaohui 九州大学, 大学院理学研究院, 助教 (60596849)
MATSUSHIMA Ayami 九州大学, 大学院理学研究院, 准教授 (60404050)
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| Research Collaborator |
SHIMOHIGASHI Miki
MATSUO Ayaka
MATSUYAMA Yutaka
SUGIYAMA Makiko
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥46,150,000 (Direct Cost: ¥35,500,000、Indirect Cost: ¥10,650,000)
Fiscal Year 2017: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2016: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2015: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
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| Keywords | 有害化学物質 / 内分泌かく乱物質 / ビスフェノール / 核内受容体 / シグナル毒性 / ビスフェノールＡ |
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| Outline of Final Research Achievements |
The aim of this project is to clarify the nuclear receptor-mediated molecular mechanisms of signal toxicity and low-dose effects of endocrine disruptor bisphenol A. As a result, the followings to prove those objectives have been elucidated. Those include (i) BPA-exposure causes hyperactivity both in the fruit fly Drosophila, and mice, (ii) such hyperactivity was found to associate with the disorder of genes of circadian rhythm-transmitting neuropeptides, (iii) the disorder appeared to originate from the suppression or facilitation of DNA methylation, and (iv) BPA’s high transcriptional activation activity is due to the cooperative work with highly constitutively active self-activated nuclear receptors.
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