| Project/Area Number |
15H01767
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Tokyo University of Agriculture |
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Principal Investigator |
UEHARA Mariko 東京農業大学, 応用生物科学部, 教授 (20211071)
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| Co-Investigator(Kenkyū-buntansha) |
高橋 信之 東京農業大学, 応用生物科学部, 准教授 (50370135)
井上 博文 東京農業大学, 応用生物科学部, 助教 (10639305)
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| Co-Investigator(Renkei-kenkyūsha) |
KATSUMATA Shin-ichi 東京農業大学, 応用生物科学部, 准教授 (10424681)
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| Research Collaborator |
Felix Angelina DR. University of the Philippines Los Baños, Institute of Human Nutrition and Food, College of Human Ecology, Associate Professor
IKUSHIRO Shin-ichi 富山県立大学, 工学研究科, 教授
MUROTA Kaeko 島根大学, 生物資源科学部, 教授
KATSUMATA Rie (TSUBOI Rie) 東京農業大学, 応用生物科学部, 助手
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥41,340,000 (Direct Cost: ¥31,800,000、Indirect Cost: ¥9,540,000)
Fiscal Year 2017: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2016: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2015: ¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
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| Keywords | ファイトケミカル / ポリフェノール / 含硫化合物 / 炎症制御 / ロコモティブシンドローム / メタボリックシンドローム / 破骨細胞 / シグナル伝達 / フィトケミカル / 骨粗鬆症 / 植物性機能物質(フィトケミカル) / 生理活性物質 |
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| Outline of Final Research Achievements |
In this study, we focused on the anti-inflammatory effects of functional phytochemicals, and aimed at simultaneous prevention of lifestyle-related diseases caused by chronic inflammation, especially locomotive/metabolic syndromes. First, we screened anti-inflammatory effects of phytochemicals by using osteoclasts (OC) in vitro, since OC is activated in inflammatory condition. Equol enantiomers, isoflavone metabolites, and suforaphane, a sulfur-containing compound, were found as effective compounds for anti-osteoclastogenesis. We determined the detailed mechanism in OC, and examined the anti-inflammatory effects of those phytochemicals in chronic inflammatory disease modeled animals. Regarding anti-metabolic syndrome, we used black/brown rice extracts, which involved anthocyanins and other ingredients as physiological active substances. The extracts inhibited hepatic fat accumulation via activation of PPAR-alpha in obese and type II diabetes model mouse with high fat diet intake.
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