Translational study on exercise program for promoting vitality of body and mind: unravel the mechanism of enhancing motivation and cognitive function in brain.
| Project/Area Number |
15H01828
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
SOYA Hideaki 筑波大学, 体育系, 教授 (50221346)
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| Co-Investigator(Kenkyū-buntansha) |
McHugh Thomas 国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (50553731)
功刀 浩 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 疾病研究第三部, 部長 (40234471)
大石 久史 筑波大学, 医学医療系, 准教授 (30375513)
岡本 正洋 筑波大学, 体育系, 助教 (30726617)
松井 崇 筑波大学, 体育系, 助教 (80725549)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥40,300,000 (Direct Cost: ¥31,000,000、Indirect Cost: ¥9,300,000)
Fiscal Year 2017: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2016: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Fiscal Year 2015: ¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
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| Keywords | 運動 / 認知機能 / fMRI / 意欲 / DREADDシステム / 低強度運動 / ドーパミン / DREADD / 海馬歯状回 |
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| Outline of Final Research Achievements |
Stress and/or lack of exercise cause lower vitality within our body and mind, especially cause cognitive dysfunction that related to hippocampus. To solve this problem, it is necessary to develop the new exercise prescription for increasing continuously willing on exercise. In this study, the effect of low intensity exercise (LE) and high intensity interval training (HIT) was both examined on human and animals studies. Our results showed that HIT could also enhance cognitive function just as ME did. In addition, acute mild exercise in human also revealed enhanced hippocampal function. Furthermore, LE was also effective for improving cognitive function in the disease animal model of cognitive dysfunction. In summary, our results demonstrated and established the new exercise prescription and is expecting to become the basic concepts for applying to clinical practice in the future.
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Report
(4 results)
Research Products
(113 results)
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[Journal Article] Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I.2017
Author(s)
Fernandez AM, Hernandez-Garzon E, Perez-Domper P, Perez-Alvarez A, Mederos S, Matsui T, Santi A, Trueba-Saiz A, Garcia-Guerra L, Pose-Utrilla J, Fielitz J, Olson EN, De la Rosa RF, Garcia L, Pozo MA, Iglesias T, Araque A, Soya H, Perea G, Martin ED, Torres-Aleman I
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Journal Title
Diabetes
Volume: 66
Issue: 1
Pages: 64-74
DOI
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Peer Reviewed / Int'l Joint Research
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[Journal Article] Hormetic effects by exercise on hippocampal neurogenesis with glucocorticoid signaling.2015
Author(s)
Okamoto M, Yamamura Y, Liu Y, Lee M, Matsui T, Shima T, Soya M, Takahashi K, Soya S, McEwen BS, Soya H
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Journal Title
Brain Plasticity
Volume: 1
Issue: 1
Pages: 149-158
DOI
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Peer Reviewed / Acknowledgement Compliant
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[Book] たくましい心とかしこい体－身心統合のスポーツサイエンス-2016
Author(s)
征矢英昭, 坂入洋右, 高木英樹, 中込四郎, 鈴木健嗣, 前田清司, 長谷川聖修, 遠藤卓郎, 菊池章人, 大石純子, 酒井利信, 林洋輔, 江田香織, 西保岳, 森達人, 清水諭
Total Pages
256
Publisher
株式会社大修館書店
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