Circadian clock oscillation in the SCN
| Project/Area Number |
15H01843
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic / Social brain science
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAGUCHI YOSHIAKI 京都大学, 薬学研究科, 助教 (30467427)
FUSTIN JEAN-MICHEL 京都大学, 薬学研究科, 特定講師 (50711818)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥40,170,000 (Direct Cost: ¥30,900,000、Indirect Cost: ¥9,270,000)
Fiscal Year 2017: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2016: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2015: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
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| Keywords | 概日リズム / 時計遺伝子 / シグナル伝達 / 視交叉上核 / Gタンパク質 / 細胞周期 / 時差 / 昼寝 / 生体リズム / RNAメチル化 / カゼインキナーゼ / 遺伝子 / GPCR / 脳・神経 / 生体分子 / 神経科学 / 細胞・組織 / 神経回路 / 生理学 / 時間生物学 / 光ファイバー / ルシフェラーゼ |
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| Outline of Final Research Achievements |
In Drosophila, it was elucidated that the transcription and translation feedback loop of the clock gene causes a circadian rhythm with a period of about 24 hours, and it won the 2017 Nobel Prize in Medicine and Physiology. We cloned mammalian Per gene in 1997, and clarified that the circadian oscillation was not generated simply clock genes by themselves, but needs intercellular neurotransmission among clock oscillating cells. In this research project, we identified GPR176-cAMP system as a key system to generate the rhythm, mathematical model of jet lag, alternative splicing of Ck1d gene for determining period length, mammalian calcitonin receptor in temperature regulation during nap, and role of Per for the formation of polyploidization.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] <b>Circadian rhythms of micturition during jet </b><b>lag </b>2018
Author(s)
Ito K, Yasuda M, Maeda Y, Fustin JM, Yamaguchi Y, Kono Y, Negoro H, Kanematsu A, Ogawa O, Doi M, and Okamura H
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Journal Title
Biomedical Research
Volume: 39
Issue: 2
Pages: 57-63
DOI
NAID
ISSN
0388-6107, 1880-313X
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Two Ck1δ transcripts regulated by m6A methylation code for two antagonistic kinases in the control of the circadian clock2018
Author(s)
Fustin, JM, Kojima R, Itoh K, Chang H-Y, Shiqi Y, Zhuang B, Oji A, Gibo S, Narasimamurthy R, Virshup D, Kurosawa G, Doi M, Manabe I, Ishihama Y, Ikawa M, Okamura H
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Journal Title
Proc Natl Acad Sci USA
Volume: 印刷中
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] <i><b>Gm7325</b></i><b> is MyoD-dependently expressed in activated muscle satellite </b><b>cells </b>2017
Author(s)
Takei D, Nishi M, Fukada S, Doi M, Okamura H, Uezumi A, Zhang L, Yoshida M, Miyazato M, Ichimura A, Takeshima H.
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Journal Title
Biomedical Research
Volume: 38
Issue: 3
Pages: 215-219
DOI
NAID
ISSN
0388-6107, 1880-313X
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway.2017
Author(s)
Chao HW, Doi M, Fustin JM, Chen H, Murase K, Maeda Y, Hayashi H, Tanaka R, Sugawa M, Mizukuchi N, Yamaguchi Y, Yasunaga J, Matsuoka M, Sakai M, Matsumoto M, Hamada S, and Okamura H
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Journal Title
Nature Commun.
Volume: 8
Issue: 1
Pages: 2238-2238
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Gpr176 is a Gz-linked orphan G-protein coupled receptor that sets the pace of circadian behavior.2016
Author(s)
Doi M, Murai I, Kunisue S, Setsu G, Uchio N, Tanaka R, Kobayashi S, Shimatani H, Hayashi H, Chao HW, Nakagawa Y, Takahashi Y, Hotta Y, Yasunaga JI, Matsuoka M, Hastings MH, Kiyonari H, and Okamura H.
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Journal Title
Nat Commun
Volume: 7
Issue: 1
Pages: 10583-10583
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] 3ß-hydroxysteroid dehydrogenase isoforms in human aldosterone-producing adenoma2015
Author(s)
Konosu-Fukaya S, Nakamura Y, Satoh F, Ono Y, Felizola SJ, Ise K, Maekawa T, Takeda K, Katsu K, Fujishima F, Kasajima A, Watanabe M, Arai Y, Gomez-Sanchez EP, Gomez-Sanchez CE, Doi M, Okamura H, and Sasano H
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Journal Title
Mol. Cell. Endocrinol.
Volume: 印刷中
Pages: 205-212
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 生体時計と肝臓2015
Author(s)
岡村 均
Organizer
第42回日本小児栄養消化器肝臓学会
Place of Presentation
広島国際会議場
Year and Date
2015-10-18
Related Report
Invited
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