Creation of bioactive compounds by activation and engineering of microbial secondary metabolite biosynthetic genes

• Project/Area Number: 15H02445
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Bioorganic chemistry
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Osada Hiroyuki 国立研究開発法人理化学研究所, 環境資源科学研究センター, 副センター長 (80160836)
• Co-Investigator(Kenkyū-buntansha): 加藤 直樹 国立研究開発法人理化学研究所, 環境資源科学研究センター, 研究員 (90442946)
• Co-Investigator(Renkei-kenkyūsha): TAKAHASHI Shunji 国立研究開発法人理化学研究所, 環境資源科学研究センター, ユニットリーダー (30311608) ; FUTAMURA Yushi 国立研究開発法人理化学研究所, 環境資源科学研究センター, 研究員 (70525857)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥42,250,000 (Direct Cost: ¥32,500,000、Indirect Cost: ¥9,750,000); Fiscal Year 2017: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000); Fiscal Year 2016: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000); Fiscal Year 2015: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
• Keywords: 生物活性物質 / ケミカルバイオロジー / 二次代謝産物

Outline of Final Research Achievements

Natural products that possess structural diversity and show a wide range of specific biological activities have been an important resource for the development of pharmaceutical drugs and agrochemicals. In this project, we focused on secondary metabolites produced by microorganisms to establish a methodology for the discovery of new bioactive compounds by means of new chemical biology research tools constructed by ourselves, such as NPPlot, MorphoBase, ChemProteoBase, and photoaffinity beads. A number of new microbial metabolites were isolated by genetic engineering and manipulation of regulatory systems, and evaluated their biological activities, leading to a creation of seeds for the drug discovery.

Research Products

• [Journal Article] Biosynthesis and structure activity relationship studies of okaramines that target insect glutamate-gated chloride channels (2018)
  • Author(s): Kato Naoki、Furutani Shogo、Otaka Junnosuke、Noguchi Akira、Kinugasa Kiyomi、Kai Kenji、Hayashi Hideo、Ihara Makoto、Takahashi Shunji、Matsuda Kazuhiko、Osada Hiroyuki
  • Journal Title: ACS Chemical Biology Volume: 13 Issue: 3 Pages: 561-566
  • DOI: 10.1021/acschembio.7b00878
  • Peer Reviewed
• [Journal Article] Identification of a small-molecule ligand of β-arrestin1 as an inhibitor of stromal fibroblast cell migration accelerated by cancer cells (2018)
  • Author(s): Suvarna K, Honda K, Kondoh Y, Osada H, Watanabe N.
  • Journal Title: Cancer Med Volume: 7 Issue: 3 Pages: 883-893
  • DOI: 10.1002/cam4.1339
  • Peer Reviewed / Open Access
• [Journal Article] Identification of cytotoxic, glutathione-reactive moieties inducing accumulation of reactive oxygen species via glutathione depletion (2018)
  • Author(s): Wilke J, Kawamura T, Watanabe N, Osada H, Ziegler S, Waldmann H.
  • Journal Title: Bioorg Med Chem Volume: 26 Issue: 8 Pages: 1453-1461
  • DOI: 10.1016/j.bmc.2017.11.009
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Wakodecalines A and B, new decaline metabolites isolated from a fungus Pyrenochaetopsis sp. RK10-F058 (2018)
  • Author(s): Nogawa T, Kato N, Shimizu T, Okano A, Futamura Y, Takahahi S, Osada H
  • Journal Title: The Journal of Antibiotica Volume: 71 Issue: 1 Pages: 123-128
  • DOI: 10.1038/ja.2017.103
  • Peer Reviewed
• [Journal Article] Development of a terpenoid-production platform in Streptomyces reveromyceticus SN-593 (2017)
  • Author(s): Khalid A、Takagi H、Panthee S、Muroi M、Chappell J、Osada H、Takahashi S
  • Journal Title: ACS Synthetic Biology Volume: 6 Issue: 12 Pages: 2339-2349
  • DOI: 10.1021/acssynbio.7b00249
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Regulatory mechanism of mycotoxin tenuazonic acid production in Pyricularia oryzae (2017)
  • Author(s): Yun CS, Motoyama T, Osada H
  • Journal Title: ACS Chem Biol Volume: 12 Issue: 9 Pages: 2270-2274
  • DOI: 10.1021/acschembio.7b00353
  • Peer Reviewed
• [Journal Article] Identification of a gene cluster for telomestatin biosynthesis and heterologous expression using a specific promoter in a clean host. (2017)
  • Author(s): 4.Amagai, K., Ikeda, H., Hashimoto, J., Kozone, I., Izumikawa, M., Kudo, F., Eguchi, T., Nakamura, T., Osada, H., Takahashi, S., Shin-ya
  • Journal Title: Sci. Rep. Volume: 7 Issue: 1 Pages: 3382-3382
  • DOI: 10.1038/s41598-017-03308-5
  • Peer Reviewed / Open Access
• [Journal Article] Functional annotation of chemical libraries across diverse biological processes. (2017)
  • Author(s): Piotrowski JS, Li SC, Deshpande R.......Shirahige K,......Boone C.
  • Journal Title: Nat Chem Biol. Volume: 13 Issue: 9 Pages: 982-993
  • DOI: 10.1038/nchembio.2436
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Hitoyol A and B, Two Norsesquiterpenoids from the Basidiomycete Coprinopsis cinerea (2017)
  • Author(s): Otaka Junnosuke、Hashizume Daisuke、Masumoto Yui、Muranaka Atsuya、Uchiyama Masanobu、Koshino Hiroyuki、Futamura Yushi、Osada Hiroyuki
  • Journal Title: Organic Letters Volume: 19 Issue: 15 Pages: 4030-4033
  • DOI: 10.1021/acs.orglett.7b01784
  • Peer Reviewed
• [Journal Article] Identification of a trichothecene production inhibitor by chemical array and library screening using trichodiene synthase as a target protein. (2017)
  • Author(s): 3.Maeda K., Nakajima Y., Motoyama T., Kondoh Y., Kawamura T., Kanamaru K., Ohsato S., Nishiuchi T., Yoshida M., Osada H., Kobayashi T., Kimura M.
  • Journal Title: Pestic. Biochem. Physiol Volume: 138 Pages: 1-7
  • DOI: 10.1016/j.pestbp.2017.03.006
  • NAID: 120006523682
  • Peer Reviewed
• [Journal Article] Structure-activity relationships of terpendole E and its natural derivatives. (2017)
  • Author(s): Nagumo Y, Hayashi T, Hirota H, Aono H, Kawatani M, Osada H, Usui T
  • Journal Title: ChemistrySelect Volume: 2 Issue: 4 Pages: 1533-1536
  • DOI: 10.1002/slct.201602015
  • Peer Reviewed
• [Journal Article] Trachyspic acid 19-butyl ester, a new inhibitor of Plk1 polo box domain-dependent recognition from uncharacterized fungus RKGS-F2684. (2017)
  • Author(s): Nogawa T, Ogita N, Futamura Y, Negishi S, Watanabe N, Osada H
  • Journal Title: J Antibiot Volume: 70 Issue: 5 Pages: 705-707
  • DOI: 10.1038/ja.2016.167
  • Peer Reviewed
• [Journal Article] Octaminomycins A and B, Cyclic Octadepsipeptides Active against Plasmodium falciparum. (2017)
  • Author(s): Jang JP, Nogawa T, Futamura Y, Shimizu T, Hashizume D, Takahashi S, Jang JH, Ahn JS, Osada H
  • Journal Title: J Nat Prod Volume: 80 Issue: 1 Pages: 134-140
  • DOI: 10.1021/acs.jnatprod.6b00758
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Opantimycin A, a new metabolite isolated from Streptomyces sp. RK88-1355. (2017)
  • Author(s): Nogawa T, Okano A, Lim CL, Futamura Y, Shimizu T, Takahashi S, Ibrahim D, Osada H
  • Journal Title: J Antibiot Volume: 70 Issue: 2 Pages: 222-225
  • DOI: 10.1038/ja.2016.113
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] RK-144171, a new benadrostin derivative produced by Streptomyces sp. RK88-1441. (2017)
  • Author(s): Jang JP, Takahashi S, Futamura Y, Nogawa T, Jang JH, Ahn JS, Osada H
  • Journal Title: J Antibiot Volume: 70 Issue: 1 Pages: 102-104
  • DOI: 10.1038/ja.2016.65
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Identification and structure-activity relationship of purine derivatives as novel MTH1 inhibitors. (2016)
  • Author(s): Kumar A, Kawamura T, Kawatani M, Osada H, Zhang KY
  • Journal Title: Chem Biol Drug Des Volume: - Issue: 6 Pages: 862-869
  • DOI: 10.1111/cbdd.12909
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Proteomic profiling reveals that collismycin A is an iron chelator. (2016)
  • Author(s): Kawatani M, Muroi M, Wada A, Inoue G, Futamura Y, Aono H, Shimizu K, Shimizu T, Igarashi Y, Takahashi-Ando N, Osada H
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 38385-38385
  • DOI: 10.1038/srep38385
  • Peer Reviewed / Open Access
• [Journal Article] Stachybotrysin, an Osteoclast Differentiation Inhibitor from the Marine-Derived Fungus Stachybotrys sp. KCB13F013. (2016)
  • Author(s): Kim JW, Ko SK, Kim HM, Kim GH, Son S, Kim GS, Hwang GJ, Jeon ES, Shin KS, Ryoo IJ, Hong YS, Oh H, Lee KH, Soung NK, Hashizume D, Nogawa T, Takahashi S, Kim BY, Osada H, Jang JH, Ahn JS
  • Journal Title: J Nat Prod Volume: 79 Issue: 10 Pages: 2703-2708
  • DOI: 10.1021/acs.jnatprod.6b00641
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Identification of a novel sesquiterpene biosynthetic machinery involved in astellolide biosynthesis. (2016)
  • Author(s): Shinohara Y, Takahashi S, Osada H, Koyama Y
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 32865-32865
  • DOI: 10.1038/srep32865
  • Peer Reviewed / Open Access
• [Journal Article] Comparative chemical array screening for p38γ/δ MAPK inhibitors using a single gatekeeper residue difference between p38α/β and p38γ/δ. (2016)
  • Author(s): Kondoh Y, Honda K, Hiranuma S, Hayashi T, Shimizu T, Watanabe N, Osada H
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 29881-29881
  • DOI: 10.1038/srep29881
  • Peer Reviewed / Open Access
• [Journal Article] High-throughput screening identifies artesunate as selective inhibitor of cancer stemness: Involvement of mitochondrial metabolism. (2016)
  • Author(s): Subedi A, Futamura Y, Nishi M, Ryo A, Watanabe N, Osada H
  • Journal Title: Biochem Biophys Res Commun Volume: 477 Issue: 4 Pages: 737-742
  • DOI: 10.1016/j.bbrc.2016.06.128
  • Peer Reviewed
• [Journal Article] Discovery of novel selenium derivatives as Pin1 inhibitors by high-throughput screening. (2016)
  • Author(s): Subedi A, Shimizu T, Ryo A, Sanada E, Watanabe N, Osada H
  • Journal Title: Biochem Biophys Res Commun Volume: 474 Issue: 3 Pages: 528-533
  • DOI: 10.1016/j.bbrc.2016.04.124
  • Peer Reviewed
• [Journal Article] Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival. (2016)
  • Author(s): Kawamura T, Kawatani M, Muroi M, Kondoh Y, Futamura Y, Aono H, Tanaka M, Honda K, Osada H
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 26521-26521
  • DOI: 10.1038/srep26521
  • Peer Reviewed / Open Access
• [Journal Article] Unantimycin A, a new neoantimycin analog isolated from a microbial metabolite fraction library (2016)
  • Author(s): Lim CL., Nogawa T., Okano A., Futamura Y., Kawatani M., Takahashi S. Ibrahim D., Osada H.
  • Journal Title: The Journal of Antibiotics Volume: AOP Issue: 6 Pages: 456-458
  • DOI: 10.1038/ja.2015.124
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Identification of a novel compound that inhibits osteoclastogenesis by suppressing nucleoside transporters. (2016)
  • Author(s): S. Katsuyama, K. Sugino, Y. Sasazawa, Y. Nakano, H. Aono, K. Morishita, M. Kawatani, K. Umezawa, H. Osada and S. Simizu
  • Journal Title: FEBS Letters Volume: 590 Issue: 8 Pages: 1152-1162
  • DOI: 10.1002/1873-3468.12146
  • Peer Reviewed
• [Journal Article] Biosynthetic approaches to creating bioactive fungal metabolites: Pathway engineering and activation of secondary metabolism. (2016)
  • Author(s): Motoyama T, Osada H
  • Journal Title: Bioorg Med Chem Lett Volume: 26 Issue: 24 Pages: 5843-5850
  • DOI: 10.1016/j.bmcl.2016.11.013
  • Peer Reviewed
• [Journal Article] Chemical and biological studies of reveromycin A. (2016)
  • Author(s): Osada H
  • Journal Title: J Antibiot Volume: 69 Issue: 10 Pages: 723-730
  • DOI: 10.1038/ja.2016.57
  • Peer Reviewed
• [Journal Article] Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1 (2016)
  • Author(s): Ursu A, Illich DJ, Takemoto Y, Porfetye AT, Zhang M, Brockmeyer A, Janning P, Watanabe N, Osada H, Vetter IR, Ziegler S, Schöler HR, Waldmann H
  • Journal Title: Cell Chem Biol Volume: 23 Issue: 4 Pages: 494-507
  • DOI: 10.1016/j.chembiol.2016.02.015
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] New Cyclic Lipopeptides of the Iturin Class Produced by Saltern-Derived Bacillus sp. KCB14S006 (2016)
  • Author(s): Son S, Ko SK, Jang M, Kim JW, Kim GS, Lee JK, Jeon ES, Futamura Y, Ryoo IJ, Lee JS, Oh H, Hong YS, Kim BY, Takahashi S, Osada H, Jang JH, Ahn JS.
  • Journal Title: Mar Drugs Volume: 14 Issue: 4 Pages: 72-72
  • DOI: 10.3390/md14040072
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Small molecules that target phosphorylation dependent protein-protein interaction (2016)
  • Author(s): Watanabe N, Osada H
  • Journal Title: Bioorg Med Chem Volume: 印刷中 Issue: 15 Pages: 30171-30177
  • DOI: 10.1016/j.bmc.2016.03.023
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Integrated profiling methods for identifying the targets of bioactive compounds: MorphoBase and ChemProteoBase (2016)
  • Author(s): Muroi M, Futamura Y, Osada H
  • Journal Title: Nat Prod Rep Volume: 33 Issue: 5 Pages: 621-625
  • DOI: 10.1039/c5np00106d
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Structures and biological activities of azaphilones produced by Penicillium sp. KCB11A109 from a ginseng field (2016)
  • Author(s): Son S, Ko SK, Kim JW, Lee JK, Jang M, Ryoo IJ, Hwang GJ, Kwon MC, Shin KS, Futamura Y, Hong YS, Oh H, Kim BY, Ueki M, Takahashi S, Osada H, Jang JH, Ahn JS.
  • Journal Title: Phytochemistry Volume: 122 Pages: 154-164
  • DOI: 10.1016/j.phytochem.2015.12.008
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis (2016)
  • Author(s): Kakeya, H., Kaida, D., Sekiya, H., Nagai, K., Yoshida, M., and Osada, H.
  • Journal Title: J. Antibiot. (Tokyo) Volume: 69 Issue: 2 Pages: 121-123
  • DOI: 10.1038/ja.2015.94
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] An overproduction of astellolides induced by genetic disruption of chromatin-remodeling factors in Aspergillus oryzae (2016)
  • Author(s): Shinohara Y, Kawatani M, Futamura Y, Osada H, Koyama Y
  • Journal Title: J Antibiot Volume: 69 Issue: 1 Pages: 4-8
  • DOI: 10.1038/ja.2015.73
  • Peer Reviewed
• [Journal Article] Reveromycin A Administration Prevents Alveolar Bone Loss in Osteoprotegerin Knockout Mice with Periodontal Disease (2015)
  • Author(s): Mizuno M, Miyazawa K, Tabuchi M, Tanaka M, Yoshizako M, Minamoto C, Torii Y, Tamaoka Y, Kawatani M, Osada H, Maeda H, Goto S
  • Journal Title: Sci Rep Volume: 5 Issue: 1 Pages: 16510-16510
  • DOI: 10.1038/srep16510
  • Peer Reviewed / Open Access
• [Journal Article] Identification of middle chain fatty acyl-CoA ligase responsible for the biosynthesis of 2-alkylmalonyl-CoA for polyketide extender unit (2015)
  • Author(s): Miyazawa T., Takahashi S., Kawata A., Panthee S., Hayashi T., Shimizu T., Nogawa T., Osada H.
  • Journal Title: The Journal of Biological Chemistry Volume: 290 Issue: 45 Pages: 26994-27011
  • DOI: 10.1074/jbc.m115.677195
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Haenamindole, an unusual diketopiperazine derivative from a marine-derived Penicillium sp. KCB12F005 (2015)
  • Author(s): Kim JW, Ko SK, Son S, Shin KS, Ryoo IJ, Hong YS, Oh H, Hwang BY, Hirota H, Takahashi S, Kim BY, Osada H, Jang JH, Ahn JS
  • Journal Title: Bioorg Med Chem Lett Volume: 25 Issue: 22 Pages: 5398-5401
  • DOI: 10.1016/j.bmcl.2015.09.026
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Neuritogenic Activity of Tetradecyl 2,3-Dihydroxybenzoate Is Mediated through the Insulin-Like Growth Factor 1 Receptor/Phosphatidylinositol 3 Kinase/Mitogen-Activated Protein Kinase Signaling Pathway (2015)
  • Author(s): Tang R, Gao L, Kawatani M, Chen J, Cao X, Osada H, Xiang L, Qi J
  • Journal Title: Mol Pharmacol Volume: 88 Issue: 2 Pages: 326-334
  • DOI: 10.1124/mol.115.097758
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Novel abscisic acid antagonists identified with chemical array screening. (2015)
  • Author(s): Ito T, Kondoh Y, Yoshida K, Umezawa T, Shimizu T, Shinozaki K, Osada H
  • Journal Title: Chembiochem Volume: 16 Issue: 17 Pages: 2471-2478
  • DOI: 10.1002/cbic.201500429
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS-PKS hybrid enzyme (2015)
  • Author(s): Choong-Soo Yun, Takayuki Motoyama & Hiroyuki Osada
  • Journal Title: Nature Communications Volume: 6 Issue: 1 Pages: 8758-8758
  • DOI: 10.1038/ncomms9758
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Identification of matrix metalloproteinase inhibitors by chemical arrays. (2015)
  • Author(s): Kawatani M, Fukushima Y, Kondoh Y, Honda K, Sekine T, Yamaguchi Y, Taniguchi N, Osada H
  • Journal Title: Biosci Biotechnol Biochem Volume: 79 Issue: 10 Pages: 1597-1602
  • DOI: 10.1080/09168451.2015.1045829
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] RK-270A-C, new oxindole derivatives isolated from a microbial metabolites fraction library of Streptomyces sp. RK85-270. (2015)
  • Author(s): Jang JP, Nogawa T, Uramoto M, Okano A, Futamura Y, Shimizu T, Takahashi S, Jang JH, Ahn JS, Osada H.
  • Journal Title: J Antibiot (Tokyo) Volume: 68 Issue: 4 Pages: 293-295
  • DOI: 10.1038/ja.2014.141
  • Peer Reviewed / Open Access
• [Journal Article] A new enzyme involved in the control of the stereochemistry in the decalin formation during equisetin biosynthesis. (2015)
  • Author(s): Kato N, Nogawa T, Hirota H, Jang JH, Takahashi S, Ahn JS, Osada H.
  • Journal Title: Biochem Biophys Res Commun Volume: 460 Issue: 2 Pages: 210-215
  • DOI: 10.1016/j.bbrc.2015.03.011
  • NAID: 130007491120
  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of malaria parasite growth by quinomycin A and its derivatives through DNA-intercalating activity. (2015)
  • Author(s): Hayase H, Watanabe N, Lim CL, Nogawa T, Komatsuya K, Kita K, Osada H.
  • Journal Title: Biosci Biotechnol Biochem Volume: 79 Issue: 4 Pages: 633-635
  • DOI: 10.1080/09168451.2014.987205
  • Peer Reviewed / Open Access
• [Journal Article] Construction and application of a photo-cross-linked chemical array. (2015)
  • Author(s): Kondoh Y, Honda K, Osada H
  • Journal Title: Methods Mol Biol 2015;1263:29-41 Volume: 1263 Pages: 29-41
  • DOI: 10.1007/978-1-4939-2269-7_3
  • ISBN: 9781493922680, 9781493922697
  • Peer Reviewed / Open Access
• [Presentation] 破骨細胞を標的とするリベロマイシンA：生物活性研究から生合成研究への展開 (2018)
  • Author(s): 長田裕之
  • Organizer: 日本薬学会第138回年会
  • Invited
• [Presentation] 担子菌類Coprinopsis cinereaからの新規骨格を有する2種のノルセスキテルペノイド (2018)
  • Author(s): 大髙潤之介、二村友史、長田裕之
  • Organizer: 日本農芸化学会2018年度大会
• [Presentation] 糸状菌Pyrenochaetopsis sp. RK10-F058より単離した新規デカリン骨格含有二次代謝産物wakodecaline Cの構造 (2018)
  • Author(s): 野川俊彦、加藤直樹、清水猛、岡野亜紀子、二村友史、高橋俊二、長田裕之
  • Organizer: 日本農芸化学会2018年度大会
• [Presentation] がん代謝阻害剤スクリーニングと呼吸阻害作用解析 (2018)
  • Author(s): 室井誠、二村友史、青野晴美、川谷誠、関根朋美、野川俊彦、林田莉奈、長田裕之
  • Organizer: 日本農芸化学会2018年度大会
• [Presentation] がん代謝研究を加速するオミックス解析基盤の構築 (2018)
  • Author(s): 佐竹華子、二村友史、室井誠、野川俊彦、川谷誠、井本正哉、長田裕之
  • Organizer: 日本農芸化学会2018年度大会
• [Presentation] Pyricularia oryzaeにおけるテヌアゾン酸生産誘導化合物の探索と作用機構解析 (2018)
  • Author(s): 本山高幸、田中陽子、長田裕之
  • Organizer: 日本農芸化学会2018年度大会
• [Presentation] 立体選択的デカリン形成を担うFsa2ファミリーDiels-Alderaseの機能解析 (2018)
  • Author(s): 加藤直樹、野川俊彦、衣笠清美、高橋俊二、長田裕之
  • Organizer: 日本農芸化学会2018年度大会
• [Presentation] リベロマイシン生合成に関わるサクシニル化酵素群の機能解析 (2018)
  • Author(s): 鬼頭奈央子、高橋 俊二、佐藤裕美、奥村英夫、熊坂崇、長田裕之
  • Organizer: 日本農芸化学会2018年度大会
• [Presentation] テヌアゾン酸の環状骨格形成を担うケトシンターゼドメインの結晶化解析 (2018)
  • Author(s): 尹忠銖、西本一希、本山高幸、日野智也、永野真吾、長田裕之
  • Organizer: 日本農芸化学会2018年度大会
• [Presentation] イネいもち病菌におけるpyriculol類生合成関連aldo/keto reductase遺伝子の機能解析 (2018)
  • Author(s): 古山祐貴、本山高幸、野川俊彦、清田洋正、鎌倉高志、長田裕之
  • Organizer: 日本農芸化学会2018年度大会
• [Presentation] Tolypocladium albumにおけるNPD938による二次代謝産物生合成遺伝子の発現誘導機構 (2018)
  • Author(s): 石井友彬、本山高幸、鎌倉高志、長田裕之
  • Organizer: 日本農芸化学会2018年度大会
• [Presentation] がん代謝を阻害するプレニルフラボノイドの作用機序解析 (2018)
  • Author(s): 二村友史、青野晴美、佐竹華子、室井誠、川谷誠、野川俊彦、井本正哉、長田裕之
  • Organizer: 日本農芸化学会2018年度大会
• [Presentation] がん細胞に活性酸素種産生を誘導する化合物のスクリーニング (2018)
  • Author(s): 河村達郎、WILKE Julian、渡辺信元、ZIEGLER Slava、WALDMANN Herbert、長田裕之
  • Organizer: 日本農芸化学会2018年度大会
• [Presentation] 新規アントラキノンkinanthraquinoneの同定と生物活性評価 (2018)
  • Author(s): 高木海、野川俊彦、二村友史、長田裕之、高橋俊二
  • Organizer: 日本農芸化学会2018年度大会
• [Presentation] Candida albicansに菌糸形態を誘導する化合物RK-276Aのケミカルバイオロジー研究 (2018)
  • Author(s): 山本甲斐、二村友史、清水猛、長田裕之
  • Organizer: 日本農芸化学会2018年度大会
• [Presentation] 抗生物質学からケミカルバイオロジーへの展開（微生物創薬研究の温故知新） (2018)
  • Author(s): 長田裕之
  • Organizer: 日本技術士会化学部会 2月度 講演会
  • Invited
• [Presentation] Systematic Isolation of Microbial Metabolites and the Target Identification (2018)
  • Author(s): Hiroyuki Osada
  • Organizer: International Symposium on Himalayan Biodiversity Bioresources
  • Int'l Joint Research / Invited
• [Presentation] New approach to search and isolate novel secondary metabolites from microbes for a chemical biology study (2018)
  • Author(s): Toshihiko Nogawa and Hiroyuki Osada
  • Organizer: International Symposium on Himalayan Biodiversity Bioresources
  • Int'l Joint Research
• [Presentation] Anti-osteoclastic agent, reveromycin A (biological activity and biosynthesis) (2018)
  • Author(s): Hiroyuki Osada
  • Organizer: Department of Chemistry Bicoastal Lecture Series, The Scripps Research Institute
  • Int'l Joint Research / Invited
• [Presentation] Chemical Synthesis or Biosynthesis:It is the Question for Reveromycin Production (2018)
  • Author(s): Hiroyuki Osada
  • Organizer: The Mona Symposium 2018
  • Int'l Joint Research / Invited
• [Presentation] イネいもち病菌のネクトリアピロン類の生産誘導条件の探索と大量生産株の作製 (2017)
  • Author(s): 本山 高幸, 田中 陽子, 長田 裕之
  • Organizer: 日本農芸化学会2017年度大会
  • Place of Presentation: 京都女子大学（京都府京都市）
  • Year and Date: 2017-03-17
• [Presentation] イネいもち病菌におけるピリクロール類生合成に関わるFAD依存性モノオキシゲナーゼ遺伝子の解析 (2017)
  • Author(s): 古山 祐貴, 本山 高幸, 鎌倉 高志, 野川 俊彦, 長田 裕之
  • Organizer: 日本農芸化学会2017年度大会
  • Place of Presentation: 京都女子大学（京都府京都市）
  • Year and Date: 2017-03-17
• [Presentation] じゃがいもの新規機能性成分探索に向けたフラクションライブラリーの作製 (2017)
  • Author(s): 野川 俊彦, 二村 友史, 岡野 亜紀子, 石原 克之, 須藤 麻里, 伊藤 政喜, 長田 裕之
  • Organizer: 日本農芸化学会2017年度大会
  • Place of Presentation: 京都女子大学（京都府京都市）
  • Year and Date: 2017-03-17
• [Presentation] じゃがいもフラクションライブラリーを用いた抗糖化活性の検討 (2017)
  • Author(s): 須藤 麻里, 吉原 潮梨, 石原 克之, 野川 俊彦, 二村 友史, 岡野 亜紀子, 長田 裕之
  • Organizer: 日本農芸化学会2017年度大会
  • Place of Presentation: 京都女子大学（京都府京都市）
  • Year and Date: 2017-03-17
• [Presentation] リベロマイシン生合成に関わる酸化還元酵素RevMの機能解析 (2017)
  • Author(s): 鬼頭 奈央子, 高橋 俊二, 宮澤 岳, 前島 希, 田中 美帆, 室井 誠. 奥村 英夫, 熊坂 崇, 長田 裕之
  • Organizer: 日本農芸化学会2017年度大会
  • Place of Presentation: 京都女子大学（京都府京都市）
  • Year and Date: 2017-03-17
• [Presentation] リベロマイシン生合成に関わるRevMの結晶構造解析 (2017)
  • Author(s): 奥村 英夫, 鬼頭 奈央子, 高橋 俊二, 宮澤 岳, 熊坂 崇, 長田 裕之
  • Organizer: 日本農芸化学会2017年度大会
  • Place of Presentation: 京都女子大学（京都府京都市）
  • Year and Date: 2017-03-17
• [Presentation] 化合物アレイの新たな活用法：天然物の鏡像体化合物群の活用を目指したスクリーニング法の開発 (2017)
  • Author(s): 近藤 恭光, 野口 太朗, 大石 真也, 本田 香織, 大野 浩章, 藤井 信孝, 長田 裕之
  • Organizer: 日本農芸化学会2017年度大会
  • Place of Presentation: 京都女子大学（京都府京都市）
  • Year and Date: 2017-03-17
• [Presentation] ストレプトマイセス リベロマイセティカスを用いたテルペノイド生産プラットフォームの開発 (2017)
  • Author(s): ＡＭＭＡＲＡ ＫＨＡＬＩＤ, 高木 海, ＳＵＲＥＳＨ ＰＡＮＴＨＥＥ, 長田 裕之, 高橋 俊二
  • Organizer: 日本農芸化学会2017年度大会
  • Place of Presentation: 京都女子大学（京都府京都市）
  • Year and Date: 2017-03-17
• [Presentation] プレニル化インドールアルカロイドokaramine生合成におけるazetidine環合成酵素の同定 (2017)
  • Author(s): 加藤 直樹, 大髙 潤之介, 衣笠 清美, 古谷 章悟, 高橋 俊二, 松田 一彦, 長田 裕之
  • Organizer: 日本農芸化学会2017年度大会
  • Place of Presentation: 京都女子大学（京都府京都市）
  • Year and Date: 2017-03-17
• [Presentation] がん細胞に誘起される繊維芽細胞遊走を阻害する小分子探索 (2017)
  • Author(s): 渡辺信元、Kruthi Suvarna、本田香織、近藤恭光、長田裕之
  • Organizer: 2107年度生命科学系学会合同年次大会
• [Presentation] がん代謝を標的とする小分子阻害剤の探索 (2017)
  • Author(s): 長田裕之、二村友史、室井誠
  • Organizer: 第76回日本癌学会学術総会
  • Invited
• [Presentation] グルコース非依存性がん代謝機構を標的とした小分子阻害剤の探索 (2017)
  • Author(s): 川谷誠、青野晴美、二村友史、室井誠、長田裕之
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] Exploration of small molecules targeting cancer metabolism (2017)
  • Author(s): 二村友史、青野晴美、川谷誠、長田裕之
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] Identification of a ligand compound of beta-arrestin as an inhibitor of metastasis of carcinoma associated fibroblasts (2017)
  • Author(s): Kruthi Suvarna, Hiroyuki Osada, Nobumoto Watanabe
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 糸状菌Pyrenochaetopsis sp. RK10-F058より単離した新規デカリン骨格含有二次代謝産物の構造 (2017)
  • Author(s): 野川俊彦、加藤直樹、清水猛、岡野亜紀子、二村友史、高橋俊二、長田裕之
  • Organizer: 第59回天然有機化合物討論会
• [Presentation] 真菌の形態変化を指標とした抗真菌物質YO15001A、Bの単離 (2017)
  • Author(s): 山本甲斐、二村友史、長田裕之
  • Organizer: 第32回日本放線菌学会大会
• [Presentation] リベロマイシン生合成に関わるRevMの機能解析 (2017)
  • Author(s): 鬼頭奈央子、高橋俊二、佐藤裕美、奥村英夫、熊坂崇、長田裕之
  • Organizer: 第32回日本放線菌学会大会
• [Presentation] 植物病原糸状菌の感染戦略におけるテヌアゾン酸生産の関与 (2017)
  • Author(s): 柏毅、本山高幸、長田裕之
  • Organizer: 平成29年度植物感染生理談話会
• [Presentation] 破骨細胞を標的とするreveromycin Aの研究 (2017)
  • Author(s): 長田裕之
  • Organizer: 筑波大学WPIセミナー「有機化学・創薬化学セミナー」
  • Invited
• [Presentation] 抗生物質学からケミカルバイオロジーへの展開（微生物創薬研究の温故知新） (2017)
  • Author(s): 長田裕之
  • Organizer: ライフサイエンス技術部会・反応分科会 講演会
  • Invited
• [Presentation] 的を射る難しさ (2017)
  • Author(s): 長田 裕之
  • Organizer: 第52回 天然物化学談話会
  • Invited
• [Presentation] エネルギー代謝を標的とした小分子化合物の探索 (2017)
  • Author(s): 二村友史、川谷誠、青野晴美、長田裕之
  • Organizer: 第21回日本がん分子標的治療学会学術集会
• [Presentation] グルコース非依存性がん代謝機構を標的とした小分子阻害剤の探索 (2017)
  • Author(s): 川谷誠、青野晴美、二村友史、室井誠、長田裕之
  • Organizer: 第21回日本がん分子標的治療学会学術集会
• [Presentation] アルテスネイトはミトコンドリア障害を介して幹細胞特異的生存阻害を引き起こす (2017)
  • Author(s): 渡辺信元、二村友史、長田裕之
  • Organizer: 第21回日本がん分子標的治療学会学術集会
• [Presentation] ケミカルバイオロジーの威力 (2017)
  • Author(s): 長田 裕之
  • Organizer: 関西学院大学化学セミナー
  • Invited
• [Presentation] ChemProteoBase を用いた化合物のオフターゲット解析 (2017)
  • Author(s): 室井誠、川谷誠、河村達郎、近藤恭光、二村友史、田中美帆、青野晴美、本田香織、長田裕之
  • Organizer: 日本ケミカルバイオロジー学会 第12回年会
• [Presentation] 植物病原糸状菌が生産する二次代謝産物テヌアゾン酸は宿主の抵抗性を誘導する (2017)
  • Author(s): 柏毅、本山高幸、長田裕之
  • Organizer: 平成29年度日本植物病理学会大会
• [Presentation] Chemical array screening, a powerful approach for exploring small molecule inhibitors against proteins (2017)
  • Author(s): Hiroyuki Osada
  • Organizer: International Symposium “Systems Glycobiology and Beyond”
  • Int'l Joint Research / Invited
• [Presentation] Screening and target identification of small molecules affecting cancer metabolism (2017)
  • Author(s): Hiroyuki Osada
  • Organizer: ICBS 2017
  • Int'l Joint Research / Invited
• [Presentation] Biosynthesis and regulatory mechanism of mycotoxin tenuazonic acid in Pyricularia oryzae (2017)
  • Author(s): Choong-Soo Yun, Takayuki Motoyama, Hiroyuki Osada
  • Organizer: 3rd KRIBB-RIKEN Chemical Biology Joint Symposium
  • Int'l Joint Research
• [Presentation] Application of a fraction library for new metabolites search (2017)
  • Author(s): Toshihiko Nogawa, Akiko Okano, Yushi Futamura, Takeshi Shimizu, Nobumoto Watanabe, Shunji Takahashi, Hiroyuki Osada
  • Organizer: 3rd KRIBB-RIKEN Chemical Biology Joint Symposium
  • Int'l Joint Research
• [Presentation] Exploration of novel antifungal substances based on fungal morphological changes (2017)
  • Author(s): Kai Yamamoto, Yushi Futamura, Takeshi Shimizu, Hiroyuki Osada
  • Organizer: 3rd KRIBB-RIKEN Chemical Biology Joint Symposium
  • Int'l Joint Research
• [Presentation] Fsa2-family Diels-Alderases are responsible for the stereoselective decaline formation (2017)
  • Author(s): Naoki Kato, Toshihiko Nogawa, Kiyomi Kinugasa, Shunji Takahashi, Hiroyuki Osada
  • Organizer: 3rd KRIBB-RIKEN Chemical Biology Joint Symposium
  • Int'l Joint Research
• [Presentation] Identification of pyrrolizilactone biosynthetic gene cluster of the fungus RKB3564 (2017)
  • Author(s): Sayaka Hirosawa, Naoki Kato, Kiyomi Kinugasa, Shunji Takahashi, Hiroyuki Osada
  • Organizer: 3rd KRIBB-RIKEN Chemical Biology Joint Symposium
  • Int'l Joint Research
• [Presentation] New secondary metabolites from Basidiomycete (2017)
  • Author(s): Junnosuke Otaka and Hiroyuki Osada
  • Organizer: 3rd KRIBB-RIKEN Chemical Biology Joint Symposium
  • Int'l Joint Research
• [Presentation] Analysis of an FAD-dependent Monooxygenase Gene Involved in Pyriculol Biosynthesis (2017)
  • Author(s): Yuki Furuyama, Takayuki Motoyama, Toshihiko Nogawa, Takashi Kamakura, Hiroyuki Osada
  • Organizer: 3rd KRIBB-RIKEN Chemical Biology Joint Symposium
  • Int'l Joint Research
• [Presentation] Identification of novel anthraquinone biosynthetic gene cluster (2017)
  • Author(s): Risa Takao, Naoko Kito, Hiroshi Takagi, Hiroyuki Osada, Shunji Takahashi
  • Organizer: 3rd KRIBB-RIKEN Chemical Biology Joint Symposium
  • Int'l Joint Research
• [Presentation] Inhibitor of stromal fibroblast migration accelerated by cancer cells (2017)
  • Author(s): Kruthi Suvarna, Kaori Honda, Yasumitsu Kondoh, Hiroyuki Osada, Nobumoto Watanabe
  • Organizer: 3rd KRIBB-RIKEN Chemical Biology Joint Symposium
  • Int'l Joint Research
• [Presentation] Pentapeptides from Streptomyces sp. RK88-1441 by using the one strain-many compounds strategy (2017)
  • Author(s): Jun-Pil Jang, Gwi Ja Hwang, Min Cheol Kwon, In-Ja Ryoo, Sung-Kyun Ko, Jae-Hyuk Jang, Hiroyuki Osada, Jong Seong Ahn
  • Organizer: 3rd KRIBB-RIKEN Chemical Biology Joint Symposium
  • Int'l Joint Research
• [Presentation] Analysis of lucilactaene biosynthesis gene cluster (2017)
  • Author(s): Sho Kato, Takayuki Motoyama, Hiroyuki Osada
  • Organizer: 3rd KRIBB-RIKEN Chemical Biology Joint Symposium
  • Int'l Joint Research
• [Presentation] Activation of the sleeping gene cluster of microbial secondary metabolites (2017)
  • Author(s): Hiroyuki Osada
  • Organizer: 9th US-Japan Seminar on the Biosynthesis of Natural Products
  • Int'l Joint Research / Invited
• [Presentation] Screening of Inhibitors against Cancer Stem Cells from Natural Products Depository (NPDepo) (2017)
  • Author(s): Hiroyuki Osada
  • Organizer: 18th International Symposium on the Biology of Actinomycetes (ISBA18)
  • Int'l Joint Research / Invited
• [Presentation] Structure-activity relationship of NPD9055, a small-molecule inducer of reactive oxygen species (2017)
  • Author(s): Tatsuro Kawamura, Erchang Shang, Gernot Hahne, Sonja Sievers, Slava Ziegler, Nobumoto Watanabe, Herbert Waldmann, Hiroyuki Osada
  • Organizer: RIKEN-Max Planck Joint Research Center for System Chemical Biology, The 6th Symposium
  • Int'l Joint Research
• [Presentation] Novel application of chemical array: Screening approach for drug discovery from natural product enantiomers (2017)
  • Author(s): Yasumitsu Kondoh, Kaori Honda, Taro Noguchi, Shinya Oishi, Hiroaki Ohno, Nobutaka Fujii, and Hiroyuki Osada
  • Organizer: RIKEN-Max Planck Joint Research Center for System Chemical Biology, The 6th Symposium
  • Int'l Joint Research
• [Presentation] A proteomic profiling, ChemProteoBase, reveals non-proteinous target of compounds (2017)
  • Author(s): Makoto Muroi, Makoto Kawatani, Akira Wada, Miho Tanaka, and Hiroyuki Osada
  • Organizer: RIKEN-Max Planck Joint Research Center for System Chemical Biology, The 6th Symposium
  • Int'l Joint Research
• [Presentation] Artesunate selectively inhibits of cancer stemness through the mitochondrial dysfunction (2017)
  • Author(s): Nobumoto Watanabe, Amit Subedi, Yushi Futamura, Akihide Ryo and Hiroyuki Osada
  • Organizer: RIKEN-Max Planck Joint Research Center for System Chemical Biology, The 6th Symposium
  • Int'l Joint Research
• [Presentation] Screening of small molecule inhibitors of human pirin (2017)
  • Author(s): Hiroyuki Osada
  • Organizer: 253rd American Chemical Society National Meeting & Exposition
  • Int'l Joint Research / Invited
• [Presentation] Analysis of MTH1 inhibitors by ChemProteoBase, the drug-target analysis system based on proteomic profiling. (2016)
  • Author(s): Muroi M, Kawatani M, Kawamura T, Futamura Y, Osada H
  • Organizer: The 21st JFCR-International Symposium on Cancer Chemotherapy (JFCR-ISCC)
  • Place of Presentation: Miraikan (National Museum of Emerging Science and Innovation) (Tokyo, Japan)
  • Year and Date: 2016-12-14
  • Int'l Joint Research
• [Presentation] アルテスネイトはミトコンドリアを標的として、肝細胞特異的にがん細胞生存を阻害する (2016)
  • Author(s): 渡辺 信元, Amit Sbedi, 二村 友史, 梁明秀, 長田 裕之
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-11-30
• [Presentation] Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival (2016)
  • Author(s): Kawamura T, Kawatani M, Muroi M, Kondoh Y, Futamura Y, Aono H, Tanakaa M, Honda K, Osada H
  • Organizer: 28th EORTC-NCI-AACR SYMPOSIUM
  • Place of Presentation: ICM - Internationales Congress Center Munich (Munich, Germany)
  • Year and Date: 2016-11-30
  • Int'l Joint Research
• [Presentation] フサリセチンAの特徴的な環構造形成を担う環化酵素の同定 (2016)
  • Author(s): 加藤 直樹, 衣笠 清美，Jae-Hyuk JANG，高橋 俊二，Jong Seog AHN，長田 裕之
  • Organizer: 第16回糸状菌分子生物学コンファレンス
  • Place of Presentation: 宇治おうばくプラザ（京都大学宇治キャンパス内）（京都府宇治市）
  • Year and Date: 2016-11-17
• [Presentation] 分子標的治療薬開発の落とし穴 (2016)
  • Author(s): 長田 裕之
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-10-06
  • Invited
• [Presentation] Characterization of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival (2016)
  • Author(s): 河村 達郎, 川谷 誠, 室井 誠, 青野 晴美, 二村 友史, 長田 裕之
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-10-06
• [Presentation] エネルギー代謝プロファイリングを用いたがん代謝阻害剤の探索研究 (2016)
  • Author(s): 二村 友史, 青野 晴美, 川谷 誠, 室井 誠, 長田 裕之
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-10-06
• [Presentation] 化合物アレイ法による医薬シードの探索 (2016)
  • Author(s): 長田 裕之
  • Organizer: 第89回日本生化学会大会
  • Place of Presentation: 東北大学（宮城県仙台市）
  • Year and Date: 2016-09-25
  • Invited
• [Presentation] The role of the MTH1 enzyme in cancer gave rise to controversy (2016)
  • Author(s): Kawamura T, Kawatani M, Osada H
  • Organizer: The First Asian 3 Roundtable Meeting on Chemical Probe Research Hub
  • Place of Presentation: Hotel LEOPALACE Hakata (Fukuoka, Japan)
  • Year and Date: 2016-09-22
  • Int'l Joint Research
• [Presentation] 放線菌Streptomyces sp. RK88-1355より単離した新規Opantimycin Aの構造 (2016)
  • Author(s): 野川 俊彦, リム・チュンリャン, 岡野 亜紀子, 二村 友史, 清水 猛, 高橋 俊二, 長田 裕之
  • Organizer: 第58回天然有機化合物討論会
  • Place of Presentation: 東北大学（宮城県仙台市）
  • Year and Date: 2016-09-14
• [Presentation] Activation of fungal secondary metabolism by disturbance of the two-component signal transduction system and identification of the nectriapyrone biosynthetic gene cluster (2016)
  • Author(s): Motoyama T, Tanaka Y, Osada H
  • Organizer: 9th Joint Natural Products Conference 2016
  • Place of Presentation: Tivoli Congress Centre (Copenhagen, Denmark)
  • Year and Date: 2016-07-26
  • Int'l Joint Research
• [Presentation] Comparative chemical array screening of p38γ/δ MAPK inhibitors by focusing on a single gatekeeper residue difference between p38α/β and p38γ/δ (2016)
  • Author(s): Kondoh Y, Honda K, Hiranuma S, Shimizu T, Osada H
  • Organizer: 17th Tetrahedron Symposium
  • Place of Presentation: MeliaSitges Hotel Congress Centre (Sitges, Barcelona, Spain)
  • Year and Date: 2016-06-30
  • Int'l Joint Research
• [Presentation] Stereospecific ring formation in biosynthesis of specialized microbial metabolites (2016)
  • Author(s): Osada H
  • Organizer: 17th Tetrahedron Symposium
  • Place of Presentation: MeliaSitges Hotel Congress Centre (Sitges, Barcelona, Spain)
  • Year and Date: 2016-06-29
  • Int'l Joint Research / Invited
• [Presentation] 酸化ヌクレオチド加水分解酵素MTH1阻害剤の作用解析 (2016)
  • Author(s): 川谷 誠, 河村 達郎, 室井 誠, 青野 晴美, 二村 友史, 田中 美帆, 長田 裕之
  • Organizer: 第20回日本がん分子標的治療学会学術集会
  • Place of Presentation: 別府国際コンベンションセンター（大分県別府市）
  • Year and Date: 2016-05-30
• [Presentation] エネルギー代謝プロファイリングを用いたがん代謝阻害薬の探索研究 (2016)
  • Author(s): 二村 友史, 川谷 誠, 青野 晴美, 室井 誠, 田中 美帆, 長田 裕之
  • Organizer: 第20回日本がん分子標的治療学会学術集会
  • Place of Presentation: 別府国際コンベンションセンター（大分県別府市）
  • Year and Date: 2016-05-30
• [Presentation] リン酸化特異的プロリン異性化酵素Pin1の新規阻害小分子の単離 (2016)
  • Author(s): 渡邉 信元, 長田 裕之
  • Organizer: 第20回日本がん分子標的治療学会学術集会
  • Place of Presentation: 別府国際コンベンションセンター（大分県別府市）
  • Year and Date: 2016-05-30
• [Presentation] Identification of MTH1inhibitors by chemical arrays (2016)
  • Author(s): Kawamura T, Kawatani M, Kondoh Y, Muroi M, Futamura Y, Aono H, Tanaka M, Honda K, Osada H
  • Organizer: RIKEN-Max Planck Joint Research Center for Systems Chemical Biology The 5th Symposium
  • Place of Presentation: Harnack-Haus, Tagungsstatte der Max-Planck-Gesellschaft (Berlin, Germany)
  • Year and Date: 2016-04-17
  • Int'l Joint Research
• [Presentation] Expansion of ChemProteoBase for the analysis of compounds affecting cancer metabolism (2016)
  • Author(s): Muroi M, Tanaka M, Osada H
  • Organizer: RIKEN-Max Planck Joint Research Center for Systems Chemical Biology The 5th Symposium
  • Place of Presentation: Harnack-Haus, Tagungsstatte der Max-Planck-Gesellschaft (Berlin, Germany)
  • Year and Date: 2016-04-17
  • Int'l Joint Research
• [Presentation] 14-3-3 protein-porotein interaction inhibitors identified by high throughput screening (2016)
  • Author(s): Watanabe N, Osada H
  • Organizer: RIKEN-Max Planck Joint Research Center for Systems Chemical Biology The 5th Symposium
  • Place of Presentation: Harnack-Haus, Tagungsstatte der Max-Planck-Gesellschaft (Berlin, Germany)
  • Year and Date: 2016-04-17
  • Int'l Joint Research
• [Presentation] Comparative chemical array screening for p38γ/δ MAPK inhibitors using a single gatekeeper residue difference between p38α/β and p38γ/δ (2016)
  • Author(s): Kondoh Y, Honda K, Hiranuma S, Shimizu T, Osada H
  • Organizer: RIKEN-Max Planck Joint Research Center for Systems Chemical Biology The 5th Symposium
  • Place of Presentation: Harnack-Haus, Tagungsstatte der Max-Planck-Gesellschaft (Berlin, Germany)
  • Year and Date: 2016-04-17
  • Int'l Joint Research
• [Presentation] Fragment arrays for early druggability assessments (2016)
  • Author(s): Jonas Aretz, Yasumitsu Kondoh, Kaori Honda, Upendra Rao Anumala, Marc Nazare, Nobumoto Watanabe, Hiroyuki Osada, Christoph Rademacher
  • Organizer: RIKEN-Max Planck Joint Research Center for Systems Chemical Biology The 5th Symposium
  • Place of Presentation: Harnack-Haus, Tagungsstatte der Max-Planck-Gesellschaft (Berlin, Germany)
  • Year and Date: 2016-04-17
  • Int'l Joint Research
• [Presentation] 抗生物質学のすすめ (2016)
  • Author(s): 長田 裕之
  • Organizer: 第42回 農芸化学「化学と生物」シンポジウム
  • Place of Presentation: 札幌市教育文化会館 （北海道札幌市)
  • Year and Date: 2016-03-27
  • Invited
• [Presentation] Chemical array screening of matrix metalloproteinase inhibitors (2016)
  • Author(s): 近藤 恭光, 川谷 誠, 本田 香織, 関根 朋美, 長田 裕之
  • Organizer: 日本農芸化学会 2016年度大会
  • Place of Presentation: 札幌コンベンションセンター 札幌市産業振興センター （北海道札幌市)
  • Year and Date: 2016-03-27
• [Presentation] プレニル化インドールアルカロイドokaramineの遺伝学的手法による生合成経路解析 (2016)
  • Author(s): 加藤 直樹, 古谷 章悟, 大髙 潤之介, 衣笠 清美, 高橋 俊二, 松田 一彦, 長田 裕之
  • Organizer: 日本農芸化学会 2016年度大会
  • Place of Presentation: 札幌コンベンションセンター 札幌市産業振興センター （北海道札幌市)
  • Year and Date: 2016-03-27
• [Presentation] 微生物フラクションライブラリーより単離した新規ネオアンチマイシン類縁体ウナンチマイシンAの構造 (2016)
  • Author(s): 野川 俊彦, リム・チュンリャン, 岡野 亜紀子, 二村 友史, 川谷 誠, 高橋 俊二, ダーラ・イブラヒム, 長田裕之
  • Organizer: 日本農芸化学会 2016年度大会
  • Place of Presentation: 札幌コンベンションセンター 札幌市産業振興センター （北海道札幌市)
  • Year and Date: 2016-03-27
• [Presentation] ChemProteoBaseによるがん代謝作用薬の解析 (2016)
  • Author(s): 室井 誠, 田中 美帆, 長田 裕之
  • Organizer: 日本農芸化学会 2016年度大会
  • Place of Presentation: 札幌コンベンションセンター 札幌市産業振興センター （北海道札幌市)
  • Year and Date: 2016-03-27
• [Presentation] 真菌の形態変化を指標とした抗真菌物質の探索研究 (2016)
  • Author(s): 山本 甲斐, 二村 友史, 植木 雅志, 鈴木 龍一郎, 白瀧 義明, 長田裕之
  • Organizer: 日本農芸化学会 2016年度大会
  • Place of Presentation: 札幌コンベンションセンター 札幌市産業振興センター （北海道札幌市)
  • Year and Date: 2016-03-27
• [Presentation] イネいもち病菌のピリクロール類生合成遺伝子クラスターの同定 (2016)
  • Author(s): 古山 祐貴, 本山 高幸, 鎌倉 高志, 長田裕之
  • Organizer: 日本農芸化学会 2016年度大会
  • Place of Presentation: 札幌コンベンションセンター 札幌市産業振興センター （北海道札幌市)
  • Year and Date: 2016-03-27
• [Presentation] カビ由来新規NRPS-PKS融合酵素によるカビ毒テヌアゾン酸の生合成 (2016)
  • Author(s): 尹 忠銖, 本山 高幸, 長田 裕之
  • Organizer: 日本農芸化学会 2016年度大会
  • Place of Presentation: 札幌コンベンションセンター 札幌市産業振興センター （北海道札幌市)
  • Year and Date: 2016-03-27
• [Presentation] イネいもち病菌におけるカビ毒テヌアゾン酸の生合成 (2016)
  • Author(s): 尹 忠銖, 本山 高幸, 長田 裕之
  • Organizer: 第59回 日本放線菌学会学術講演会
  • Place of Presentation: 東京電機大学 (東京都足立区)
  • Year and Date: 2016-03-07
• [Presentation] Screening of small molecule compounds with activity to selectively inhibit the cancer stem cell properties (2016)
  • Author(s): Hiroyuki Osada
  • Organizer: Tenth AACR-JCA Joint Conference on Breakthroughs in Cancer Research: From Biology to Therapeutics
  • Place of Presentation: Hyatt Regency Maui （Maui, Hawaii, USA）
  • Year and Date: 2016-02-16
  • Int'l Joint Research
• [Presentation] Discovery and analyses of 14-3-3 protein-protein interaction inhibitors identified by high throughput screening (2016)
  • Author(s): Nobumoto Watanabe, Hiroyuki Osada
  • Organizer: Tenth AACR-JCA Joint Conference on Breakthroughs in Cancer Research: From Biology to Therapeutics
  • Place of Presentation: Hyatt Regency Maui （Maui, Hawaii, USA）
  • Year and Date: 2016-02-16
  • Int'l Joint Research
• [Presentation] Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS-PKS hybrid enzyme (2016)
  • Author(s): Yun CS, Motoyama T, Osada H
  • Organizer: The 8th Korea-Japan Chemical Biology symposium
  • Place of Presentation: Okinawa Institute of Science and Technology Graduate University （Naha, Okinawa, Japan）
  • Year and Date: 2016-01-19
  • Int'l Joint Research
• [Presentation] Characterization of middle chain fatty acyl-CoA ligase responsible for the biosynthesis of 2-alkylmalonyl-CoAs for polyketide extender unit (2016)
  • Author(s): Miyazawa H, Takahashi S, Shimizu T, Nogawa T, Osada H
  • Organizer: The 8th Korea-Japan Chemical Biology symposium
  • Place of Presentation: Okinawa Institute of Science and Technology Graduate University （Naha, Okinawa, Japan）
  • Year and Date: 2016-01-19
  • Int'l Joint Research
• [Presentation] Discovery of a new enzyme involved in the stereoselective decalin formation during equisetin biosynthesis (2016)
  • Author(s): Kato N, Nogawa T, Hirota H, Takahashi S, Jang JH, Ahn JS, Osada H
  • Organizer: The 8th Korea-Japan Chemical Biology symposium
  • Place of Presentation: Okinawa Institute of Science and Technology Graduate University （Naha, Okinawa, Japan）
  • Year and Date: 2016-01-19
  • Int'l Joint Research
• [Presentation] Bioactive compounds from Plant Roots (2016)
  • Author(s): Otaka J, Futamura Y, Osada H
  • Organizer: The 8th Korea-Japan Chemical Biology symposium
  • Place of Presentation: Okinawa Institute of Science and Technology Graduate University （Naha, Okinawa, Japan）
  • Year and Date: 2016-01-19
  • Int'l Joint Research
• [Presentation] Phenotypic screening of small molecules targeting cancer metabolism (2016)
  • Author(s): Futamura Y, Kawatani M, Aono H, Muroi M, Tanaka M, Osada H
  • Organizer: The 8th Korea-Japan Chemical Biology symposium
  • Place of Presentation: Okinawa Institute of Science and Technology Graduate University （Naha, Okinawa, Japan）
  • Year and Date: 2016-01-19
  • Int'l Joint Research
• [Presentation] 化合物アレイによる創薬シードの探索 (2015)
  • Author(s): 長田 裕之
  • Organizer: 日本薬学会関東支部第40回学術講演会 創薬イノベーションを支える最先端サイエンス
  • Place of Presentation: 日本薬学会長井記念館 長井記念ホール (東京都渋谷区)
  • Year and Date: 2015-12-26
  • Invited
• [Presentation] Biosynthesis study aiming at creation of an anti-osteoclast drug (2015)
  • Author(s): Hiroyuki Osada, Toshihiko Nogawa, Shunji Takahashi
  • Organizer: The international chemical congress of pacific basin societies (Pacifichem) 2015
  • Place of Presentation: Hawaii Convention Center 他 （Honolulu, Hawaii, USA）
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Discovery and target identification of pyrrolizilactone, a fungal metabolite (2015)
  • Author(s): Hiroyuki Osada, Yushi Futamura, Toshihiko Nogawa
  • Organizer: The international chemical congress of pacific basin societies (Pacifichem) 2015
  • Place of Presentation: Hawaii Convention Center 他 （Honolulu, Hawaii, USA）
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] A new enzyme involved in the control of the stereochemistry in the decalin formation during equisetin biosynthesis (2015)
  • Author(s): Naoki Kato, Toshihiko Nogawa, Hiroshi Hirota, Shunji Takahashi, Jae-Hyuk Jang, Jong Seog Ahn, Hiroyuki Osada
  • Organizer: The international chemical congress of pacific basin societies (Pacifichem) 2015
  • Place of Presentation: Hawaii Convention Center 他 （Honolulu, Hawaii, USA）
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Iolation of new metabolites from a microbial metabolites fraction library by NPPlot screening (2015)
  • Author(s): Toshihiko Nogawa, Akiko Okano, Jang Jun-Pil, Takeshi Shimizu, Shunji Takahashi, Hiroyuki Osada
  • Organizer: The international chemical congress of pacific basin societies (Pacifichem) 2015
  • Place of Presentation: Hawaii Convention Center 他 （Honolulu, Hawaii, USA）
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Characterization of fatty acyl-CoA ligase for the biosynthesis of the extender unit of reveromycin A (2015)
  • Author(s): Shunji Takahashi, Takeshi Miyazawa, Hiroyuki Osada
  • Organizer: The international chemical congress of pacific basin societies (Pacifichem) 2015
  • Place of Presentation: Hawaii Convention Center 他 （Honolulu, Hawaii, USA）
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] 抗生物質研究を起源とするケミカルバイオロジー研究 (2015)
  • Author(s): 長田 裕之
  • Organizer: 日本農芸化学会関東支部2015年度第2回支部例会
  • Place of Presentation: 東京大学弥生講堂 一条ホール （東京都文京区）
  • Year and Date: 2015-12-12
  • Invited
• [Presentation] 糸状菌二次代謝を標的とした農薬探索 (2015)
  • Author(s): 本山 高幸, 尹 忠銖, 長田 裕之
  • Organizer: BMB2015 第38回 日本分子生物学会, 第88回 日本生物化学会大会
  • Place of Presentation: 神戸ポートアイランド (兵庫県神戸市)
  • Year and Date: 2015-12-01
• [Presentation] 新たなNRPS-PKS融合酵素によるかび毒テヌアゾン酸の生合成 (2015)
  • Author(s): 尹 忠銖, 本山 高幸, 長田 裕之
  • Organizer: 第15回糸状菌分子生物学コンファレンス
  • Place of Presentation: ルミエール府中 （東京都府中市）
  • Year and Date: 2015-11-19
• [Presentation] 昆虫制御活性物質オカラミンの生合成遺伝子クラスターの同定 (2015)
  • Author(s): 加藤 直樹, 古谷 章悟，衣笠 清美，高橋 俊二，松田 一彦，長田 裕之
  • Organizer: 第15回糸状菌分子生物学コンファレンス
  • Place of Presentation: ルミエール府中 （東京都府中市）
  • Year and Date: 2015-11-19
• [Presentation] 創農薬を志向したケミカルバイオロジー研究 (2015)
  • Author(s): 長田 裕之
  • Organizer: 第2回 グリーン科学技術研究所シンポジウム
  • Place of Presentation: グリーン科学技術研究所 (静岡県静岡市)
  • Year and Date: 2015-11-17
  • Invited
• [Presentation] Chemical array screen identifies a novel MMP inhibitor NPDK-18 that suppresses tumor cell migration (2015)
  • Author(s): Makoto Kawatani, Yasumitsu Kondoh, Kaori Honda, Tomomi Sekine, Hiroyuki Osada
  • Organizer: AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
  • Place of Presentation: Hynes Convention Center （Boston, USA）
  • Year and Date: 2015-11-05
  • Int'l Joint Research
• [Presentation] リベロマイシン生合成機構の解析 (2015)
  • Author(s): 高橋 俊二, 長田 裕之
  • Organizer: 第67回日本生物工学会大会
  • Place of Presentation: 城山観光ホテル (鹿児島県鹿児島市)
  • Year and Date: 2015-10-26
  • Invited
• [Presentation] Screening of novel antimalarial agents (2015)
  • Author(s): Hiroyuki Osada
  • Organizer: Finding Strengthening Plan of Global Network on Science, Technology and ICT, with the OECD Ministerial Meeting Daejeon 2015
  • Place of Presentation: Daejeon Convention Center （Daejeon, Korea）
  • Year and Date: 2015-10-20
  • Int'l Joint Research / Invited
• [Presentation] Screening of Novel Antimalarial Agents in RIKEN NPDepo (2015)
  • Author(s): Hiroyuki Osada
  • Organizer: Finding Strengthening Plan of Global Network on Science, Technology and ICT, with the OECD Ministerial Meeting Daejeon 2015
  • Place of Presentation: Daejeon Convention Center （Daejeon, Korea）
  • Year and Date: 2015-10-20
  • Int'l Joint Research / Invited
• [Presentation] Screening of Antimicrobial Agents in NPDepo (2015)
  • Author(s): Hiroyuki Osada
  • Organizer: RIKEN-Academia Sinica Joint Conference on Chemical Biology
  • Place of Presentation: Genomics Research Center, Academia Sinica （Taipei, Taiwan）
  • Year and Date: 2015-10-15
  • Int'l Joint Research
• [Presentation] Cell Cycle Arrest with Small Molecule Inhibitors of Phosphorylation Dependend Protein-protein Interaction (2015)
  • Author(s): Nobumoto Watanabe
  • Organizer: RIKEN-Academia Sinica Joint Conference on Chemical Biology
  • Place of Presentation: Genomics Research Center, Academia Sinica （Taipei, Taiwan）
  • Year and Date: 2015-10-15
  • Int'l Joint Research
• [Presentation] Discovery of NP428 as selective tumorsphere inhibitor (2015)
  • Author(s): Subedi Amit, Nobumoto Watanabe, Mayuko Nishii, Akihide Ryo, Hiroyuki Osada
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場 （愛知県名古屋市）
  • Year and Date: 2015-10-08
• [Presentation] リン酸化依存タンパク質間相互作用阻害による細胞周期停止の解析 (2015)
  • Author(s): 渡辺 信元, Amit Subedi, 長田 裕之
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場 （愛知県名古屋市）
  • Year and Date: 2015-10-08
• [Presentation] エキセチン生合成における立体選択的なデカリン環形成に関わる新規酵素遺伝子fsa2の発見 (2015)
  • Author(s): 加藤 直樹, 野川 俊彦, 廣田 洋, 高橋 俊二, Jae-Hyuk Jang, Jong Seog Ahn, 長田 裕之
  • Organizer: 第57回天然有機化合物討論会
  • Place of Presentation: 神奈川県民ホール （神奈川県横浜市）
  • Year and Date: 2015-09-09
• [Presentation] ポリケチド伸長単位生合成に関与する脂肪酸活性化酵素の機能解析 (2015)
  • Author(s): 宮澤 岳, 高橋 俊二, 長田 裕之
  • Organizer: 2015年度（第30回）日本放線菌学会大会
  • Place of Presentation: 富山国際会議場 （富山県富山市）
  • Year and Date: 2015-09-07
• [Presentation] Streptomyces reveromyceticusにおけるテルペノイド生合成プラットフォーム (2015)
  • Author(s): シュレス パンテー, アマラ カーリッド, 高木 海, 白井 智量, 近藤 昭彦, 長田 裕之, 高橋 俊二
  • Organizer: 2015年度（第30回）日本放線菌学会大会
  • Place of Presentation: 富山国際会議場 （富山県富山市）
  • Year and Date: 2015-09-07
• [Presentation] 遺伝子破壊実験によるテロメスタチン生合成遺伝子クラスターの同定 (2015)
  • Author(s): 天貝 啓太, 工藤 史貴, 江口 正, 長田 裕之, 池田 治生, 新家 一男, 高橋 俊二
  • Organizer: 2015年度（第30回）日本放線菌学会大会
  • Place of Presentation: 富山国際会議場 （富山県富山市）
  • Year and Date: 2015-09-07
• [Presentation] 抗生物質研究からケミカルバイオロジー研究へ (2015)
  • Author(s): 長田 裕之
  • Organizer: メディカル・サイエンス セミナー（最近話題の微生物のはなし）
  • Place of Presentation: 学士会館 （東京都千代田区)
  • Year and Date: 2015-07-08
  • Invited
• [Presentation] 分子標的治療を目指したタンパク質間相互作用阻害剤の探索 (2015)
  • Author(s): 長田 裕之
  • Organizer: 第795回千葉県がんセンター研究所集談会
  • Place of Presentation: 千葉県がんセンター （千葉県千葉市）
  • Year and Date: 2015-07-06
  • Invited
• [Presentation] フラクションライブラリーとスペクトルデータベースを利用した新規化合物探索 (2015)
  • Author(s): 野川 俊彦, Jang Jun-Pil, Lim Chung Liang, 岡野 亜紀子, 本郷 やよい, 中村 健道, 清水 猛, 高橋 俊二, 長田 裕之
  • Organizer: 第63回質量分析総合討論会
  • Place of Presentation: つくば国際会議場エポルカつくば （茨城県つくば市）
  • Year and Date: 2015-06-17
• [Presentation] モルフォベースを基盤とした抗がん物質探索：特異な線状構造体を誘導するNPD4152の発見 (2015)
  • Author(s): 二村 友史, 川谷 誠, 室井 誠, 青野 晴美, 長田 裕之
  • Organizer: 第19回日本がん分子標的治療学会学術集会
  • Place of Presentation: 松山全日空ホテル （愛媛県松山市）
  • Year and Date: 2015-06-10
• [Presentation] MorphobaseおよびChemProteoBaseを用いたGN.9482の標的同定 (2015)
  • Author(s): 青野 晴美, 川谷 誠, 二村 友史, 室井 誠, 峯岸 秀充, 中村 浩之, 長田 裕之
  • Organizer: 第19回日本がん分子標的治療学会学術集会
  • Place of Presentation: 松山全日空ホテル （愛媛県松山市）
  • Year and Date: 2015-06-10
• [Presentation] 化合物アレイを用いた新規MTH1阻害剤の探索 (2015)
  • Author(s): 河村 達郎, 川谷 誠, 長田 裕之
  • Organizer: 第19回日本がん分子標的治療学会学術集会
  • Place of Presentation: 松山全日空ホテル （愛媛県松山市）
  • Year and Date: 2015-06-10
• [Presentation] がん代謝作用薬解析におけるChemProteoBaseの利用 (2015)
  • Author(s): 室井 誠、田中 美帆、川谷 誠、長田 裕之
  • Organizer: 第19回日本がん分子標的治療学会学術集会
  • Place of Presentation: 松山全日空ホテル （愛媛県松山市）
  • Year and Date: 2015-06-10
• [Book] Bioprobes, 2nd edition (2017)
  • Author(s): Osada H (ed)
  • Total Pages: 384
  • Publisher: Springer
  • ISBN: 9784431565277