| Budget Amount *help |
¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2019: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2018: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2017: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2016: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2015: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Outline of Final Research Achievements |
MicroRNAs (miRNAs) are small, non-coding RNAs that regulate target gene expression by inducing mRNA degradation or translational inhibition. miRNAs play a critical role in many biological processes. Green tea polyphenol EGCG inhibits melanoma tumor growth by activating 67-kDa laminin receptor (67LR) signaling. EGCG up-regulated miRNA-let-7b expression through 67LR in melanoma cells. The EGCG-induced up-regulation of let-7b led to down-regulation of high mobility group A2, a target gene related to tumor progression. 67LR-dependent cAMP/protein kinase A/protein phosphatase 2A signaling pathway activation was involved in the up-regulation of let-7b expression induced by EGCG. Delphinidin, one of the anthocyanidins, shows protective effect against muscle atrophy. Delphinidin intake may prevent disuse muscle atrophy by inducing miR-23a expression and suppressing MuRF1 expression. These findings provide a basis for understanding the mechanism of miRNA regulation by functional food factors.
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