Understanding molecular mechanisms for regulation of memory retrieval by developing model mice showing deficits in memory retrieval and the applications for improvement of brain disorders
| Project/Area Number |
15H02488
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Tokyo University of Agriculture |
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Principal Investigator |
KIDA Satoshi 東京農業大学, 生命科学部, 教授 (80301547)
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| Research Collaborator |
Hasegawa Shunsuke
Ishikawa Rie
Serita Tatsurou
Morishita Yoshikazu
Nagayoshi Taikai
Fukushima Hotaka
Tanimizu Toshiyuki
Miura Daiki
Inaba Hiroyoshi
Miyahara Mizuki
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥33,540,000 (Direct Cost: ¥25,800,000、Indirect Cost: ¥7,740,000)
Fiscal Year 2017: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2016: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2015: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
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| Keywords | 概日時計 / 記憶想起 / 時計遺伝子 / 海馬 / cAMP / ドーパミン / 記憶固定化 / 脳疾患 / サーカディアンリズム / 生物時計 / BMAL1 / CREST / 脳・神経 / 記憶 / 神経科学 / 想起 |
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| Outline of Final Research Achievements |
This study using conditional mutant mice of BMAL1 showed that hippocampal circadian clock controlled by BMAL1 regulates retrieval of hippocampus-dependent memories such as contextual fear and social recognition memories. Furthermore, time-dependent regulation of these memory retrievals was also observed in wild type mice. Interestingly, BMAL1-mediated memory retrieval requires activation of Dopamine-Dopamine D1/D5 receptors-cAMP signal transduction in the hippocampus.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究から、思い出（想起）しやすい時間帯と、思い出しにくい時間帯があり、時計遺伝子BMAL1を中心とする体内時計がこの記憶想起を制御することが初めて明らかにされた。さらに、この記憶想起にはドーパミンによるcAMP情報伝達経路の活性化が必要とされる分子機構も明らかにされた。これまでに記憶想起の分子機構は明らかにされていなかったが、この記憶想起の分子機構に基づき、記憶想起改善の観点から、新たな認知症治療開発や、加齢に伴う認知機能低下の対策が進むと考えられる。
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Report
(4 results)
Research Products
(112 results)
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[Journal Article] Functional connectivity of multiple brain regions required for the consolidation of social recognition memory.2017
Author(s)
Tanimizu, T., Kenney., J.W., Okano, E., K. Kadoma., K, Frankland., P.W., Kida, S.
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Journal Title
J. Neurosci.
Volume: 37
Issue: 15
Pages: 4103-4116
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Microglial production of TNF-alpha is a key element of sustained fear memory.2017
Author(s)
Yu, Z., Fukushima, H., Ono, C., Sakai, M., Kasahara, Y., Kikuchi, Y., Gunawansa, N., Takahashi, Y., Matsuoka, H., Kida, S., Tomita, H.
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Journal Title
Brain Behav. Immun.
Volume: 59
Pages: 313-321
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Vitamin B1-deficient mice show impairment of hippocampus-dependent memory formation and loss of hippocampal neurons and dendritic spines: potential microendophenotypes of Wernicke-Korsakoff syndrome.2016
Author(s)
Inaba, H., Kishimoto, T., Oishi, S., Nagata, K., Hasegawa, S., Watanabe, T., Kida, S.
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Journal Title
Biosci. Biotechnol. Biochem.
Volume: 80
Issue: 12
Pages: 2425-2436
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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