Receptor-like cytoplasmic kinase-mediated activation of MAPK cascade in plant immunity
| Project/Area Number |
15H02489
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Kindai University |
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Principal Investigator |
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| Research Collaborator |
Yamaguchi Koji
Kojima Chojiro
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥41,080,000 (Direct Cost: ¥31,600,000、Indirect Cost: ¥9,480,000)
Fiscal Year 2018: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2017: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2016: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2015: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
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| Keywords | 植物免疫 / 受容体 / RLCK / MAPKKK / MAPK / 信号伝達 / MAPk |
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| Outline of Final Research Achievements |
Plants recognize pathogen infection by cell-surface receptors-mediated perception of pathogen associated molecular patterns, which results in intracellular activation of MAPK cascade. Subsequently, MAPKs induce a variety of defense responses. However, how MAPK cascades are activated downstream of the receptor had not been identified. In this study, we found that the receptor-like cytoplasmic kinase PBL27 connects chitin receptor and a MAPK cascade, providing a model of the MAPK activation induced by pathogen recognition.
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| Academic Significance and Societal Importance of the Research Achievements |
植物の細胞膜上に存在する多数の受容体は、細胞外に存在する病原菌、ホルモン、分泌性ペプチドを検知し、細胞内のMAPKカスケードを介して、防御応答や形態形成など様々な生体反応を誘導するが、その分子機構は不明であった。本研究成果によって提唱した「RLCKによるMAPKKKの活性化のモデル」は、植物において普遍的であり、形態形成など、植物免疫研究以外の研究にも波及効果をもたらし、作物育種の有用な基盤情報として期待される。
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Report
(5 results)
Research Products
(52 results)
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[Journal Article] The Arabidopsis CERK1-associated kinase PBL27 connects chitin perception to MAPK activation2016
Author(s)
Yamada K, Yamaguchi K, Shirakawa T, Nakagami H, Mine A, Ishikawa K, Fujiwara M, Narusaka M, Narusaka Y, Ichimura K, Kobayashi Y, Matsui H, Nomura Y, Nomoto M, Tada Y, Fukao Y, Fukamizo T, Tsuda K, Shirasu K, Shibuya N, Kawasaki T
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Journal Title
The EMBO Journal
Volume: 35(22)
Issue: 22
Pages: 2468-2483
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] The CERK1-associated kinase PBL27 regulates chitin-triggered MAPK activation through phosphorylation of MAPKKK5 in Arabidopsis2016
Author(s)
Koji Yamaguchi, Kenta Yamada, Tomomi Shirakawa, Akira Mine,Yuka Kobayashi, Masayuki Fujiwara, Kazuya Ichimura, Mari Narusaka, Yoshihiro Narusaka, Kenichi Tsuda, and Tsutomu Kawasaki
Organizer
Cold Spring Harbor Asia Conference, Latest advances in plant development & environmental response
Place of Presentation
淡路夢舞台国際会議場 (兵庫県淡路市)
Year and Date
2016-11-29
Related Report
Int'l Joint Research
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[Presentation] PBL27 directly connects between the chitin receptor, CERK1 and MAPK cascade in chitin-triggered immunity2016
Author(s)
Koji Yamaguchi, Kenta Yamada, Tomomi Shirakawa, Akira Mine, Mari Narusaka, Yoshihiro Narusaka, Kazuya Ichimura, Kenichi Tsuda, Fukamizo Tamo, Naoto Shibuya, Tsutomu Kawasaki
Organizer
2016 IS-MPMI XVII Congress
Place of Presentation
Oregon Convention Center （米国)
Year and Date
2016-07-16
Related Report
Int'l Joint Research
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[Presentation] MAPKKK5 regulates activation of MAP kinases after perception of fungal chitin in Arabidopsis2016
Author(s)
Koji Yamaguchi, Kenta Yamada, Tomomi Shirakawa, Akira Mine, Mari Narusaka, Yoshihiro Narusaka, Kazuya Ichimura, Kenichi Tsuda, Fukamizo Tamo, Naoto Shibuya, Tsutomu Kawasaki
Organizer
日本植物生理学会年会
Place of Presentation
岩手大学 （岩手県盛岡市）
Year and Date
2016-03-18
Related Report
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[Presentation] XopP, a type III effector of Xanthomonas oryzae, suppresses plant immunity via modulation of OsPUB44 ubiquitin ligase activity2015
Author(s)
Kazuya Ishikawa, Kenta Inoue, Koji Yamaguchi, Kazuaki Sakamoto, Yuichiro Muraguchi, Shiori Kitano, Madoka Ogawa, Seiji Tsuge, Tsutomu Kawasaki
Organizer
The 4th International Conference on Biotic Plant Interactions
Place of Presentation
・International Conference Hotel of Nanjing （中国）
Year and Date
2015-08-01
Related Report
Int'l Joint Research
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[Presentation] PBL27, a member of RLCKs, directly transduces immune signal from chitin receptor to MAPK cascade in plant immunity2015
Author(s)
Kenta Yamada, Koji Yamaguchi, Tomomi Shirakawa, Kazuya Ishikawa, Mari Narusaka, Yoshihiro, Narusaka, Kazuya Ichimura, Tamo Fukamizo, Naoto Shibuya, Tsutomu Kawasaki
Organizer
The 26th International Conference on Arabidopsis Research
Place of Presentation
パリコングレスセンター(フランス)
Year and Date
2015-07-03
Related Report
Int'l Joint Research
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