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Structural base and physiological significance of the interaction between TRP channels and anoctamins, and the treatment strategy with the information

Research Project

Project/Area Number 15H02501
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field General physiology
Research InstitutionCenter for Novel Science Initatives, National Institutes of Natural Sciences (2018)
Okazaki Research Facilities, National Institutes of Natural Sciences (2015-2017)

Principal Investigator

Tominaga Makoto  大学共同利用機関法人自然科学研究機構(新分野創成センター、アストロバイオロジーセンター、生命創成探究, 生命創成探究センター, 教授 (90260041)

Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥46,930,000 (Direct Cost: ¥36,100,000、Indirect Cost: ¥10,830,000)
Fiscal Year 2018: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2017: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2016: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2015: ¥23,010,000 (Direct Cost: ¥17,700,000、Indirect Cost: ¥5,310,000)
Keywords生理学 / 神経科学
Outline of Final Research Achievements

Functional interaction based on making a complex between TRPV4 with high Ca2+ permeability and Ca2+-activated chloride channel, anoctamin 1 was found to be involved in the saliva and tear secretion. And the interaction between TRPV1 and anoctamin 1 was clarified to cause enhancement of nociceptive signals in mouse sensory neurons. Furthermore, a new chemical inhibiting both TRPV1 and anoctamin 1 was found through the screening. The chemical would be a seed chemical for the development of novel analgesic agents. We also identified novel TRPA1 agonists and found that TRPA1 is activated directly by membrane stretch. Oxidation of TRPM2 by redox signals was found to be involved in the insulin secretion from mouse pancreatic β-cells. Crotamiton, a kind of anti-itch agent, was found to inhibit TRPV4. Mutation of TRPV6 was found to cause Transient Neonatal Hyperparathyroidism in human.

Academic Significance and Societal Importance of the Research Achievements

TRPチャネルは、その多くがCa2+透過性の高い非選択性陽イオンチャネルとして機能することから、流入したCa2+は細胞内で様々なCa2+依存性カスケードを活性化すると考えられている。その一つがCa2+透活性化クロライドチャネルのanoctamin 1の複合体形成を介した機能連関だと分かり、複数のTRPチャネルが機能連関を行うことが分かったことの学術的意義は大きい。この機能連関の刺激剤・阻害剤は、新たな治療薬となることが期待される。TRPチャネルの機能メカニズムを明らかにすることも治療薬開発へとつながる可能性がある。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (85 results)

All 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (19 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 19 results,  Open Access: 6 results,  Acknowledgement Compliant: 5 results) Presentation (61 results) (of which Int'l Joint Research: 35 results,  Invited: 8 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] 西交利物浦大学(中国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Possible involvement of transient receptor potential ankyrin 1 in Ca2+ signaling via T-type Ca2+ channel in mouse sensory neurons2018

    • Author(s)
      Nishizawa Yuki、Takahashi Kenji、Oguma Naoko、Tominaga Makoto、Ohta Toshio
    • Journal Title

      Journal of Neuroscience Research

      Volume: 96 Issue: 5 Pages: 901-910

    • DOI

      10.1002/jnr.24208

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 contribute to the progression of colonic inflammation in dextran sulfate sodium-induced colitis in mice.2018

    • Author(s)
      Utsumi D, Matsumoto K, Tsukahara T, Amagase K, Tominaga M, Kato S.
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 36 Issue: 3 Pages: 121-132

    • DOI

      10.1016/j.jphs.2017.12.012

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased sensory nerve excitation and bone pain associated with mouse Lewis lung cancer in TRPV1-deficient mice.2018

    • Author(s)
      Wakabayashi H, Wakisaka S, Hiraga T, Hata K, Nishimura R, Tominaga M, Yoneda T.
    • Journal Title

      J Bone Miner Metab

      Volume: 36(3) Issue: 3 Pages: 274-285

    • DOI

      10.1007/s00774-017-0842-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation2018

    • Author(s)
      Tsuchiya Masaki、Hara Yuji、Okuda Masaki、Itoh Karin、Nishioka Ryotaro、Shiomi Akifumi、Nagao Kohjiro、Mori Masayuki、Mori Yasuo、Ikenouchi Junichi、Suzuki Ryo、Tanaka Motomu、Ohwada Tomohiko、Aoki Junken、Kanagawa Motoi、Toda Tatsushi、Nagata Yosuke、Matsuda Ryoichi、Takayama Yasunori、Tominaga Makoto、Umeda Masato
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 2049-2049

    • DOI

      10.1038/s41467-018-04436-w

    • NAID

      120006471161

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] TRPV6 Variants Interfere with Maternal-Fetal Calcium Transport through the Placenta and Cause Transient Neonatal Hyperparathyroidism2018

    • Author(s)
      Suzuki Yoshiro、Chitayat David、Sawada Hirotake、Deardorff Matthew A.、McLaughlin Heather M.、Begtrup Amber、Millar Kathryn、Harrington Jennifer、Chong Karen、Roifman Maian、Grand Katheryn、Tominaga Makoto、Takada Fumio、Shuster Shirley、Obara Megumi、Mutoh Hiroshi、Kushima Reiko、Nishimura Gen
    • Journal Title

      The American Journal of Human Genetics

      Volume: 102 Issue: 6 Pages: 1104-1114

    • DOI

      10.1016/j.ajhg.2018.04.006

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypotonicity-induced cell swelling activates TRPA12018

    • Author(s)
      Fujita Fumitaka、Uchida Kunitoshi、Takayama Yasunori、Suzuki Yoshiro、Takaishi Masayuki、Tominaga Makoto
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 印刷中 Issue: 4 Pages: 431-440

    • DOI

      10.1007/s12576-017-0545-9

    • NAID

      40021574373

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRPV4 heats up ANO1-dependent exocrine gland fluid secretion2018

    • Author(s)
      Derouiche Sandra、Takayama Yasunori、Murakami Masataka、Tominaga Makoto
    • Journal Title

      FASEB J.

      Volume: 32 (4) Issue: 4 Pages: 1841-1854

    • DOI

      10.1096/fj.201700954r

    • NAID

      130007901356

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nociceptors Boost the Resolution of Fungal Osteoinflammation via the TRP Channel-CGRP-Jdp2 Axis2017

    • Author(s)
      Maruyama Kenta、Takayama Yasunori、Kondo Takeshi、Ishibashi Ken-ichi、Sahoo Bikash Ranjan、Kanemaru Hisashi、Kumagai Yutaro、Martino Mika?l M.、Tanaka Hiroki、Ohno Naohito、Iwakura Yoichiro、Takemura Naoki、Tominaga Makoto、Akira Shizuo
    • Journal Title

      Cell Reports

      Volume: 19 Issue: 13 Pages: 2730-2742

    • DOI

      10.1016/j.celrep.2017.06.002

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transient receptor potential vanilloid 4 (TRPV4) channel as a target of crotamiton and its bimodal effects.2017

    • Author(s)
      Kittaka H, Yamanoi Y, Tominaga M.
    • Journal Title

      Pfluger Archiv. Eur. J. Physiol.

      Volume: 469 Issue: 10 Pages: 1313-1323

    • DOI

      10.1007/s00424-017-1998-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] β-Eudesmol, an oxygenized sesquiterpene, stimulates appetite via TRPA1 and the autonomic nervous system2017

    • Author(s)
      Ohara Kazuaki、Fukuda Takafumi、Ishida Yuko、Takahashi Chika、Ohya Rena、Katayama Mikio、Uchida Kunitoshi、Tominaga Makoto、Nagai Katsuya
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 15785-15785

    • DOI

      10.1038/s41598-017-16150-6

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 4-isopropylcyclohexanol has potential analgesic effects through the inhibition of anoctamin 1, TRPV1 and TRPA1 channel activities.2017

    • Author(s)
      Takayama Y, Furue H, Tominaga M.
    • Journal Title

      Sci. Rep.

      Volume: 7 Issue: 1 Pages: 43132-43132

    • DOI

      10.1038/srep43132

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The molecular and cellular mechanisms of itch and the involvement of TRP channels in the peripheral sensory nervous system and skin2017

    • Author(s)
      Kittaka H, Tominaga M.
    • Journal Title

      Allergology International

      Volume: 66 Issue: 1 Pages: 22-30

    • DOI

      10.1016/j.alit.2016.10.003

    • NAID

      130005308490

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Lysophosphatidic acid-induced itch is mediated by signaling of LPA5 receptor, phospholipase D and TRPA1/TRPV1.2017

    • Author(s)
      Kittaka H, Uchida K, Fukuta N, Tominaga M.
    • Journal Title

      J. Physiol.

      Volume: 595 Issue: 8 Pages: 2681-2698

    • DOI

      10.1113/jp273961

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The thermosensitive TRPV3 channel contributes to rapid wound healing in oral epithelia2015

    • Author(s)
      Aijima R, Wang B, Takao T, Mihara H, Kashio M, Ohsaki Y, Zhang JQ, Mizuno A, Suzuki M, Yamashita Y, Masuko S, Goto M, Tominaga M, Kido MA
    • Journal Title

      The FASEB Journal

      Volume: 29 Issue: 1 Pages: 182-192

    • DOI

      10.1096/fj.14-251314

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of significant amino acids in multiple transmembrane domains of human Transient Receptor Potential Ankyrin 1 (TRPA1) for activation by eudesmol, an oxygenized sesquiterpene in hop essential oil.2015

    • Author(s)
      Ohara K, Fukuda T, Okada H, Kitao S, Ishida Y, Kato K, Takahashi C, Katayama M, Uchida K, Tominaga M.
    • Journal Title

      J. Biol. Chem.

      Volume: 290 (5) Issue: 5 Pages: 3161-3171

    • DOI

      10.1074/jbc.m114.600932

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pain-enhancing mechanism through interaction between TRPV1 and anoctamin 1 in sensory neurons2015

    • Author(s)
      Takayama Y, Uta D, Furue H, Tominaga M
    • Journal Title

      Proceedings of the National Academy of Sciences of the U S A.

      Volume: 112(16) Issue: 16 Pages: 5213-8

    • DOI

      10.1073/pnas.1421507112

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Redox signal-mediated enhancement of the temperature sensitivity of Transient Receptor Potential Melastatin 2 (TRPM2) elevated glucose-induced insulin secretion from pancreatic islets.2015

    • Author(s)
      Kashio M, Tominaga M.
    • Journal Title

      J. Biol. Chem.

      Volume: 290 Issue: 19 Pages: 12435-12442

    • DOI

      10.1074/jbc.m115.649913

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Propofol-induced pain sensation involves multiple mechanisms in sensory neurons.2015

    • Author(s)
      Nishimoto R, Kashio M, Tominaga M.
    • Journal Title

      Pfluger Archiv. Eur. J. Physiol.

      Volume: 467 Issue: 9 Pages: 190-202

    • DOI

      10.1007/s00424-014-1620-1

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRPV4 associates environmental temprerature and sex determination in the American alligator2015

    • Author(s)
      Yatsu R, Miyagawa S, Kohno S, Saito S, Ogino Y, Katsu Y, Ohta Y, Tominaga M, Guillette LJ, Iguchi T
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 18581-18581

    • DOI

      10.1038/srep18581

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] TRPV6 mutation cause neonatal transient hyperparathyroidism2019

    • Author(s)
      Yoshiro Suzuki
    • Organizer
      The 9th Federation of Asian and Oceanian Physiolosical Sciences(FAOPS2019)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] TRPV1 and ANO1/TMEM16A interaction in inflammatory pain conditions2019

    • Author(s)
      Yasunori Takayama
    • Organizer
      The 9th Federation of Asian and Oceanian Physiolosical Sciences(FAOPS2019)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Involvement of thermosensitive TRP channels in temperature-dependent microglia movement2019

    • Author(s)
      Sandra Derouiche
    • Organizer
      The 9th Federation of Asian and Oceanian Physiolosical Sciences(FAOPS2019)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of amino acids involved in the 4-isopropylcyclohexanol action on TRP channels2019

    • Author(s)
      Nguyen Thi Hong Dung
    • Organizer
      The 9th Federation of Asian and Oceanian Physiolosical Sciences(FAOPS2019)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional interaction between TRPM8 and ANO12019

    • Author(s)
      Mingyi Dong
    • Organizer
      The 9th Federation of Asian and Oceanian Physiolosical Sciences(FAOPS2019)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hypotonicity-induced cell swelling activates TRPA12019

    • Author(s)
      Fumitaka Fujita
    • Organizer
      The 9th Federation of Asian and Oceanian Physiolosical Sciences(FAOPS2019)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Inhibitory effect of a novel less-odorous TRPA1 antagonist2019

    • Author(s)
      Masayuki Takaishi
    • Organizer
      The 9th Federation of Asian and Oceanian Physiolosical Sciences(FAOPS2019)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] TRPV4 heats ups ANO1dependent exocrine gland fluid secretion2018

    • Author(s)
      Sandra Derouiche
    • Organizer
      7th Oxdative Stress, Calcium Signaling and TRP Channel World Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 炎症におけるTRPV1-ANO1相互作用の役割2018

    • Author(s)
      高山 靖規
    • Organizer
      第40回日本疼痛学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Pain enhancing mechanism through TRPV1-ANO1 interaction and its pharmacological control2018

    • Author(s)
      Yasunori Takayama
    • Organizer
      The 1st International Symposium on channelopathy and drug discovery
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ca2+輸送を担うイオンチャネルTRPV6の機能と異常2018

    • Author(s)
      鈴木 喜郎
    • Organizer
      第3回イオンチャネル研究会~チャネルフェニックス~
    • Related Report
      2018 Annual Research Report
  • [Presentation] TRPV6はヒト胎盤における母子間カルシウム輸送の分子実体である2018

    • Author(s)
      鈴木 喜郎
    • Organizer
      第13回トランスポーター研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] TRPV4 heats ups ANO1dependent exocrine gland fluid secretion2018

    • Author(s)
      Sandra Derouiche
    • Organizer
      WCP2018Kyoto(18th World Congress of Basic and Clinical Pharmacology)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Interaction between TRP channels and ANO1/TMEM16A in acute and inflammatory pain conditions2018

    • Author(s)
      Yasunori Takayama
    • Organizer
      WCP2018(World Congress on Pain)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 炎症における疼痛閾値低下の分子メカニズ2018

    • Author(s)
      高山 靖規
    • Organizer
      第8回生理研・名大合同シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] TRPV6遺伝子変異による骨疾患を伴う新生児期副甲状腺機能亢進症の発症2018

    • Author(s)
      鈴木 喜郎
    • Organizer
      第8回生理研・名大合同シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] TRPV6 is involved in the maternal-fetal calcium transport in human placenta2018

    • Author(s)
      鈴木 喜郎
    • Organizer
      日本薬物動態学会第33回年会/2018MDO国際合同学会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] TRPチャネルと痒み2018

    • Author(s)
      富永 真琴
    • Organizer
      難治性”かゆみ”の発症機構解明と予防・治療法開発の研究基盤構築・第4回学術シンポジウム
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Involvement of the thermosensitive TRP channels in temperature-dependent microglia movement2018

    • Author(s)
      Sandra Derouiche
    • Organizer
      フランス語による科学シンポジウム(J-FR 2018)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Identification of amino acids involved in the 4-isopropylcyclohexanol action on TRP channels2018

    • Author(s)
      Nguyen Thi Hong Dung
    • Organizer
      ExCELLS若手交流リトリート
    • Related Report
      2018 Annual Research Report
  • [Presentation] マウス表皮最表層におけるTRPV3の機能的発現2018

    • Author(s)
      鈴木 喜郎
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] TRPチャネルとANO1を標的とした4-イソプロピルシクロヘキサノールによる疼痛および掻痒の緩和2018

    • Author(s)
      高山 靖規
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Involvement of thermosensitive TRP channels in tempetature-dependent microglia movement2018

    • Author(s)
      Sandra Derouiche
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] TRPV4 is functionally expressed in cultured mouse Schwann cells2018

    • Author(s)
      Xiaona Feng
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 創傷治癒におけるケラチノサイトTRPV3-ANO1相互作用の役割2018

    • Author(s)
      山野井 遊
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Functional Interaction between thermosensitive TRPV4 and TMEM16A/anoctamine 1 contributes to stimulated saliva and tear secretion2017

    • Author(s)
      Sandra Derouiche
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松(静岡県・浜松市)
    • Year and Date
      2017-03-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] Functional interaction between TRPV1 and ANO1 in mouse sensory neurons2017

    • Author(s)
      Makoto Tominaga
    • Organizer
      2017 Yonsei-Korea-NIPS Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Physiological analysis of TRPV3-ANO1 interaction in keratinocytes2017

    • Author(s)
      Yu Yamanoi
    • Organizer
      2017 Yonsei-Korea-NIPS Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 温度感受性TRPチャネルと侵害刺激受容2017

    • Author(s)
      富永 真琴
    • Organizer
      第27回中国四国ペインクリニック学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 4-イソプロピルシクロヘキサノールのイオンチャネル阻害作用2017

    • Author(s)
      高山 靖規
    • Organizer
      第39回日本疼痛学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] クロタミトンのTRPV4チャネルに対する2つの作用2017

    • Author(s)
      山野井 遊
    • Organizer
      第39回日本疼痛学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 4-イソプロピルシクロヘキサノールによる包括的イオンチャネル阻害を介した鎮痛効果2017

    • Author(s)
      高山 靖規
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 体温調節機構と発汗:末梢から中枢機構の総合的解明のために2017

    • Author(s)
      富永 真琴
    • Organizer
      第25回日本発汗学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Charactarization of TRPA1 from desease vector mosquitoes2017

    • Author(s)
      Tianbang Li
    • Organizer
      第64回中部日本生理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Anoctamin 1 as a target of anti-noceptive agents2017

    • Author(s)
      Makoto Tominaga
    • Organizer
      The 7th Asian Pain Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Comprehensive reguration of ion dynamics through TRP-ANO1 interaction in primary sensory neurons2017

    • Author(s)
      Yasunori Takayama
    • Organizer
      The 7th Asian Pain Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] TRPV4 heats ups ANO-dependent exocrine glad fluid secretion2017

    • Author(s)
      Makoto Tominaga
    • Organizer
      The 16th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Involvement of TRP channels in itch2017

    • Author(s)
      Makoto Tominaga
    • Organizer
      27th International Symposium of Itch
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pharmacological effects of 4-isopropylcyclohexanol on TRP channel and ANO1/TMEM 16A2017

    • Author(s)
      Yasunori Takayama
    • Organizer
      Neuroscience2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The molecular mechanism of itch and the involvement of TRP channels2016

    • Author(s)
      橘高 裕貴
    • Organizer
      第26回国際痒みシンポジウム
    • Place of Presentation
      エーザイ(株)東京本社(東京都・文京区)
    • Year and Date
      2016-10-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Interaction of TRPv1 and ANO1 in DRG neurons2016

    • Author(s)
      高山 靖規
    • Organizer
      nternational Association for the study of Pain(IASP2016)
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-09-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] TRPV1-ANO1 interaction enhances HOT taste?2016

    • Author(s)
      高山 靖規
    • Organizer
      17th International Symposium on Olfaction and Taste(ISOT2016)
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-06-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] TRPチャンネルによる分泌現象の制御2016

    • Author(s)
      富永真琴
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      ビッグパレットふくしま(福島県・郡山市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] ANO1阻害剤の検討とそのTRPV1関連疼痛に対する効果2016

    • Author(s)
      高山 靖規
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Identification of a signal amino acid residue involved in the human TRPA1 inhibition by HC-030031 utilizing species specific differences2015

    • Author(s)
      R. Gupta
    • Organizer
      第62回中部日本生理学会
    • Place of Presentation
      富山大学(富山県・富山市)
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] Functional Interaction Between TRPV1/TRPA1 and Anoctamin 1" The 6th Asian Pain Symposium2015

    • Author(s)
      M. Tominaga
    • Organizer
      Suzhou (China)
    • Place of Presentation
      Suzhou(China)
    • Year and Date
      2015-11-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analgesic mechanisms of essential oil components2015

    • Author(s)
      M. Tominaga
    • Organizer
      The 13th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
    • Place of Presentation
      九州大学馬出キャンパス(福岡県・福岡市)
    • Year and Date
      2015-11-02
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] LPA-induced peripheral itch sensation and cellular signaling involving LPA5 receptor, phospholipase D and TRPA1/TRPV12015

    • Author(s)
      H. Kittaka
    • Organizer
      Neuroscience2015
    • Place of Presentation
      Chicago (USA)
    • Year and Date
      2015-10-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Absence of TRPV2 impaired BAT themogenesis in mice2015

    • Author(s)
      W. Sun
    • Organizer
      The 8th Asia-Oceania Conference on Obesity
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2015-10-02
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cellular and molecular signaling of lysophosphatidic acid-induced itch sensation2015

    • Author(s)
      H. Kittaka
    • Organizer
      8th World Congress on Itch
    • Place of Presentation
      春日野国際フォーラム(奈良県・奈良市)
    • Year and Date
      2015-09-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] TRP channels and pain2015

    • Author(s)
      M. Tominaga
    • Organizer
      TRP2015 3rd Leuven TRP symposium
    • Place of Presentation
      Leuven(Belgium)
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional interaction between TRPV4 and ANO1 in salivary and lacrimal acinar cells2015

    • Author(s)
      Y. Takayama
    • Organizer
      TRP2015 3rd Leuven TRP symposium
    • Place of Presentation
      Leuven(Belgium)
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of single amino acid residue involved in the human TRPA1 inhibition by HC-030031 utilizing species specific differences2015

    • Author(s)
      R. Gupta
    • Organizer
      TRP2015 3rd Leuven TRP symposium
    • Place of Presentation
      Leuven(Belgium)
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 静脈麻酔薬プロポフォールはアノクタミン1(TMEM16A)活性を抑制する2015

    • Author(s)
      西本 れい
    • Organizer
      日本麻酔科学会東海・北陸支部第13回学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2015-09-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] Regulation mechanisms of TRPV1 and TRPA12015

    • Author(s)
      M. Tominaga
    • Organizer
      12th World Congress of Veterinary Anaesthesiology
    • Place of Presentation
      京都国際会館(京都府・京都市)
    • Year and Date
      2015-09-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Molecular mechanisms of nociception in the peripheral nerve endings2015

    • Author(s)
      M. Tominaga
    • Organizer
      12th World Congress of Veterinary Anaesthesiology
    • Place of Presentation
      京都国際会館(京都府・京都市)
    • Year and Date
      2015-09-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] メントールによるアノクタミン1電流の抑制2015

    • Author(s)
      高山靖規
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-07-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウスにおけるリゾフォスファチジン酸による痒みおよびTRPA1・TRPV1を介したメカニズム2015

    • Author(s)
      橘高裕貴
    • Organizer
      第37回日本疼痛学会
    • Place of Presentation
      市民会館崇城大学ホール(熊本県・熊本市)
    • Year and Date
      2015-07-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] TRPV1,TRPA1を介した侵害刺激受容の分子機構2015

    • Author(s)
      富永真琴
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      金沢市アートホール(石川県・金沢市)
    • Year and Date
      2015-06-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Absence of TRPV2 impaired BAT themogenesis in mice2015

    • Author(s)
      W. Sun
    • Organizer
      The 5th International Ion Channel Conference
    • Place of Presentation
      Luzhou(China)
    • Year and Date
      2015-06-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Lysophosphatidic acid-induced itch sensation involves LPA5 receptor-PLD signaling and TRPA/TRPV1" 10th International Conference for Neurons and Brain Disease2015

    • Author(s)
      M. Tominaga
    • Organizer
      The 10th International Conference of Neurons and Brain Diseases
    • Place of Presentation
      Xi’an(China)
    • Year and Date
      2015-06-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 自然科学研究機構 生理学研究所 細胞生理研究部門ホームページ

    • URL

      http://www.nips.ac.jp/cs/

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Remarks] 自然科学研究機構 岡崎統合バイオサイエンスセンター 細胞生理研究部門ホームページ

    • URL

      http://www.nips.ac.jp/cs

    • Related Report
      2016 Annual Research Report
  • [Remarks] 岡崎統合バイオサイエンスセンター 細胞生理研究部門ホームページ

    • URL

      http://www.nips.ac.jp/cs/

    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 活性抑制剤および皮膚感覚過敏抑制剤2017

    • Inventor(s)
      富永真琴、高山靖規
    • Industrial Property Rights Holder
      大学共同利用機関法人自然科学研究機構
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017-02-08
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2020-03-30  

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