Development of peptides inhibiting tumor angiogenesis and metastasis to develop novel anti-cancer drug
| Project/Area Number |
15H02503
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
FUJII Ikuo 大阪府立大学, 理学系研究科, 教授 (70189984)
KITA Masaki 筑波大学, 数理物質系, 准教授 (30335012)
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| Research Collaborator |
FUNAKOSHI Yuji
YAMAUCHI Yohei
MIURA Yuki
MIYACHI Taito
Lin Yueh-Chen
Van Ngo Thai Bich
Tsai Meng-Tsz
FUJIWARA Daisuke
Tito Akindele
YONEDA kozou
YAMAGISHI kota
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥46,020,000 (Direct Cost: ¥35,400,000、Indirect Cost: ¥10,620,000)
Fiscal Year 2017: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2016: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2015: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
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| Keywords | 癌 / 腫瘍増殖 / 腫瘍血管新生 / 浸潤・転移 / シグナル伝達 / 抗癌剤 / 低分子量G蛋白質 / Arf6 / がん / 抗がん剤 / 薬理学 / 浸潤 / 浸潤仮足 / 低分子量Gタンパク質 / 転移 / GAP / GEF |
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| Outline of Final Research Achievements |
In this project, it was confirmed that the small G protein Arf6 positively regulates both tumor growth and invasion of cancer cells, and screened peptides inhibiting Arf6 activation to develop a novel anti-cancer drug. It was found that Arf6-specific GTPase-activating protein ARAP3 regulates invadopodia formation through inactivation of Arf6 in cancer cells, and that Arf6 expressed in lymphatic endothelial cells regulates tumor growth. These results demonstrate that Arf6 regulates both tumor growth and invasion/metastasis of cancer cells, and indicate that Arf6 is a candidate for developing a novel anti-cancer drug. When peptides inhibiting Arf6 activation were screened using the peptide library with about 35 amino acid residues, one peptide specifically inhibited Arf6 activation. Thus, a drug lead peptide for a novel anti-cancer drug development was successfully found.
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] PKN3 is the major regulator of angiogenesis and tumor metastasis in mice2015
Author(s)
Mukai H, Muramatsu A, Mashud R, Kubouchi K, Tsujimoto S, Hongu T, Kanaho Y, Tsubaki M, Nishida S, Shioi G, Danno S, Mehruba M, Satoh R, Sugiura R.
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 18979-18979
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] PRMT8 as a phospholipase regulates Purkinje cell dendritic arborization and motor coordination.2015
Author(s)
Kim, J.D., Park, K.E., Ishida, J., Kako, K., Hamada, J., Kani, S., Takeuchi, M., Namiki, K., Fukui, H., Fukuhara, S., Hibi, M,. Kobayashi, M., Kanaho, Y., Kasuya, Y., Mochizuki, N., Fukamizu, A.
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Journal Title
Sci. Adv.
Volume: 1
Issue: 11
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Arf6 regulates tumour angiogenesis and growth through HGF-induced endothelial β1 integrin recycling.2015
Author(s)
Hongu T, Funakoshi Y, Fukuhara S, Suzuki T, Sakimoto S, Takakura N, Ema M, Takahashi S, Itoh S, Kato M, Hasegawa H, Mochizuki N, Kanaho Y.
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Journal Title
Nat. Commun.
Volume: 6
Issue: 1
Pages: 7925-7925
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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