Analysis on the pathogenesis of inflammatory bowel diseases
| Project/Area Number |
15H02511
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
西村 潤一 大阪大学, 医学部附属病院, その他 (20379209)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAMURA Shota 大阪大学, 微生物病研究所, 特任准教授 (90432434)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥46,150,000 (Direct Cost: ¥35,500,000、Indirect Cost: ¥10,650,000)
Fiscal Year 2017: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2015: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
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| Keywords | 炎症性腸疾患 / 腸内細菌叢 / ヒト免疫 / 自然免疫 / 0 / 腸管免疫 |
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| Outline of Final Research Achievements |
We identified a novel subset of innate myeloid cells (CD160high CD163high cells) in the human intestinal lamina propria. This subset, which was present only in the intestine, produced high amounts of IL-10 and suppressed proliferation of effector T cells. In Crohn’s disease patients, suppressive function of effector T cell proliferation of the CD160high CD163high cell subset was impaired. In ulcerative colitis patients, the number of the subset was decreased and the suppressive function was also impaired. Thus, we showed that the unique subset of innate myeloid cells in the human intestinal lamina propria contributes to the maintenance of the intestinal homeostasis.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells.2017
Author(s)
Ikeda K, Kinoshita M, Kayama H, Nagamori S, Kongpracha P, Umemoto E, Okumura R, Kurakawa T, Murakami M, Mikami N, Shintani Y, Ueno S, Andou A, Ito M, Tsumura H, Yasutomo K, Ozono K, Takashima S, Sakaguchi S, Kanai Y, Takeda K.
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Journal Title
Cell Reports
Volume: 21
Issue: 7
Pages: 1824-1838
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine.2017
Author(s)
Furuta, Y., Tsai, S-H., Kinoshita, M., Fujimoto, K., Okumura, R., Umemoto, E., Kurashima, Y, Kiyono, H., Kayama, H., Takeda, K.
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Journal Title
Mucosal Immunology
Volume: 12
Issue: 2
Pages: e0172509-e0172509
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Regulation of intestinal homeostasis by theulcerative colitis-associated gene RNF186.2017
Author(s)
Fujimoto K, Kinoshita M, Tanaka H, Okuzaki D, Shimada Y, Kayama H, Okumura R, Furuta Y, Narazaki M, Tamura A, Hatakeyama S, Ikawa M, Tsuchiya K, Watanabe M, Kumanogoh A, Tsukita S, Takeda K
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Journal Title
Mucosal Immunol.
Volume: 10
Issue: 2
Pages: 446-459
DOI
Related Report
Peer Reviewed
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[Journal Article] Dysbiosis contributes to arthritis development via activation of autoreactive T cells in the intestine.2016
Author(s)
Maeda Y, Kurakawa T, Umemoto E, Motooka D, Ito Y, Gotoh K, Hirota K, Matsushita M, Furuta Y, Narazaki M, Sakaguchi N, Kayama H, Nakamura S, Iida T, Saeki Y, Kumanogoh A, Sakaguchi S, and Takeda K
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Journal Title
Arthritis Rheum
Volume: 68
Issue: 11
Pages: 2646-2661
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia.2016
Author(s)
Okumura R, Kurakawa T, Nakano T, Kayama H, Kinoshita M, Motoka D, Gotoh K, Kimura T, Kamiyama N, Kusu T, Ueda Y, Wu H, Iijima H, Barman S, Osawwa H, Matsuno H, Nishimura J, Ohba Y, Nakamura S, Iida T, Yamamoto M, Umemoto E, Sano K, and Takeda K
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Journal Title
Nature
Volume: 532
Issue: 7597
Pages: 117-121
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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