Basic and clinical research on novel targets of pulmonary arterial hypertension
| Project/Area Number |
15H02535
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
宮田 敏 東北大学, 医学系研究科, 准教授 (60360343)
佐藤 公雄 東北大学, 高度教養教育・学生支援機構, 准教授 (80436120)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥41,470,000 (Direct Cost: ¥31,900,000、Indirect Cost: ¥9,570,000)
Fiscal Year 2017: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2016: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2015: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
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| Keywords | 循環器・高血圧 / 肺高血圧症 / 医歯薬学 / 内科系臨床医学 / 循環器内科学 / 分子血管学 / 臨床応用研究 / バイオマーカー / 創薬 / 基礎研究の臨床応用 / ハイスループットスクリーニング |
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| Outline of Final Research Achievements |
Pulmonary arterial hypertension (PAH) is characterized by histological changes in the distal pulmonary arteries. In addition to genetic considerations, many environmental factors are involved in the development of PAH. All of these factors constitute complex interactions that affect pulmonary vasculature in a multi-stage manner. Thus, the identification of genes, which cause the abnormal characteristics of PASMCs, should be useful for the development of novel therapies for PAH. The characteristics of PASMCs of PAH patients (PAH-PASMCs) are different from those of healthy controls, in terms of pro-proliferative and anti-apoptotic features, which are similar to those of cancer cells. These features of PAH-PASMCs may be caused by some unknown pathogenic genes that promote PAH. Since conventional pulmonary vasodilators have limited efficacy for the treatment of severe PAH, we have performed a series of screens and found novel therapeutic targets.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Selenoprotein P promotes vascular smooth muscle cell proliferation and pulmonary hypertension -A possible novel therapeutic target-2018
Author(s)
Kikuchi N, Satoh K, Kurosawa R, Yaoita N, Md. Elias Al-Mamun, Mohammad Abdul Hai Siddique, Omura J, Satoh T, Nogi M, Sunamura S, Miyata S, Shimokawa H.
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Journal Title
Circulation
Volume: in press
Related Report
Peer Reviewed / Open Access
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[Journal Article] Sex differences in hemodynamic responses and long-term survival to optimal medical therapy in patients with pulmonary arterial hypertension.2018
Author(s)
Kozu K, Sugimura K, Aoki T, Tatebe S, Yamamoto S, Yaoita N, Shimizu T, Nochioka K, Sato H, Konno R, Satoh K, Miyata S, Shimokawa H.
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Journal Title
Heart Vessels.
Volume: in press
Issue: 8
Pages: 939-947
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] European Society of Cardiology (ESC) Annual Congress Report From Barcelona 20172017
Author(s)
Satoh K, Takahashi J, Matsumoto Y, Tatebe S, Aoki T, Kikuchi Y, Hao K, Ohyama K, Nogi M, Suda A, Kasahara S, Sato K, Ichijo S, Shimokawa H.
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Journal Title
Circulation Journal
Volume: 81
Issue: 12
Pages: 1758-1763
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed / Open Access
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[Journal Article] Comprehensive evaluation of the effectiveness and safety of balloon pulmonary angioplasty for inoperable chronic thrombo-embolic pulmonary hypertension: long-term effects and procedure-related complications.2017
Author(s)
Aoki T, Sugimura K, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kozu K, Konno R, Miyata S, Nochioka K, Satoh K, Shimokawa H.
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Journal Title
Eur Heart J.
Volume: 7
Issue: 42
Pages: 3152-3159
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The Efficacy of a Genetic Analysis of the <i>BMPR2</i> Gene in a Patient with Severe Pulmonary Arterial Hypertension and an Atrial Septal Defect Treated with Bilateral Lung Transplantation2017
Author(s)
Tatebe S, Sugimura K, Aoki T, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kozu K, Konno R, Satoh K, Fukuda K, Adachi O, Saito R, Nakanishi N, Morisaki H, Oyama K, Saiki Y, Okada Y, Shimokawa H.
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Journal Title
Internal Medicine
Volume: 56
Issue: 23
Pages: 3193-3197
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed / Open Access
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[Journal Article] Activated TAFI promotes the development of chronic thromboembolic pulmonary hypertension -A possible novel therapeutic target-2017
Author(s)
Satoh T, Satoh K, Yaoita N, Kikuchi N, Omura J, Kurosawa R, Numano K, Md. Elias-Al-Mamun, Mohammad Abdul Hai Siddique, Sunamura S, Nogi M, Suzuki K, Miyata S, Morser J, Shimokawa H.
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Journal Title
Circ Res.
Volume: 120
Issue: 8
Pages: 1246-1262
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Protective roles of endothelial AMP-activated protein kinase against hypoxia-induced pulmonary hypertension in mice.2016
Author(s)
Omura J, Satoh K, Kikuchi N, Satoh T, Kurosawa R, Nogi M, Otsuki T, Kozu K, Numano K, Suzuki K, Sunamura S, Tatebe S, Aoki T, Sugimura K, Miyata S, Hoshikawa Y, Okada Y, Shimokawa H.
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Journal Title
Circ Res.
Volume: 119
Issue: 2
Pages: 197-209
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Thrombin-activatable fibrinolysis inhibitor in chronic thromboembolic pulmonary hypertension.2016
Author(s)
Yaoita N, Satoh K, Satoh T, Sugimura K, Tatebe S, Yamamoto S, Aoki T, Miura M, Miyata S, Kawamura T, Horiuchi H, Fukumoto Y, Shimokawa H.
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Journal Title
Arterioscler Thromb Vasc Biol.
Volume: 36
Issue: 6
Pages: 1293-1301
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Selenoprotein P promotes the development of pulmonary arterial hypertension-A Possible Novel Therapeutic Target-2018
Author(s)
Kikuchi N, Satoh K, Kurosawa R, Yaoita N, Elias-Al-Mamun M, Abdul Hai Siddique M, Omura J, Satoh T, Nogi M, Sunamura S, Miyata S, Saito Y, Hoshikawa Y, Okada Y, Shimokawa H.
Organizer
World Symposium on Pulmonary Hypertension (2018年2月27～3月1日, Nice, France)
Related Report
Int'l Joint Research
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[Presentation] ADAMTS8 Promotes the Development of pulmonary arterial hypertension and right ventricular failure-A possible novel therapeutic target-2018
Author(s)
Satoh K, Omura J, Kikuchi N, Satoh T, Kurosawa R, Nogi M, Sunamura S, Ohtsuki T, Elias-Al-Mamun M, Abdul Hai Siddique M, Yaoita N, Miyata S, Hoshikawa Y, Okada Y, Shimokawa H.
Organizer
World Symposium on Pulmonary Hypertension (2018年2月27～3月1日, Nice, France)
Related Report
Int'l Joint Research
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[Presentation] Identification of celastramycin as a novel therapeutic agent for pulmonary arterial hypertension -High-throughput screening of 5,562 compounds-2018
Author(s)
Kurosawa R, Satoh K, Kikuchi N, Satoh T, Omura J, Nogi M, Sunamura S, Ohtsuki T, Yaoita N, Abdul Hai Siddique M, Elias-Al-Mamun M, Shimizu T, Shimokawa H.
Organizer
World Symposium on Pulmonary Hypertension (2018年2月27～3月1日, Nice, France)
Related Report
Int'l Joint Research
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[Presentation] Different roles of myocardial ROCK1 and ROCK2 in response to chronic pressure-overload in mice.2018
Author(s)
Sunamura S, Satoh K, Shimizu T, Suzuki K, Ikeda S, Kudo S, Omura J, Kikuchi N, Satoh T, Kurosawa R, Nogi M, Ohtsuki T, Shimokawa H.
Organizer
World Symposium on Pulmonary Hypertension (2018年2月27～3月1日, Nice, France)
Related Report
Int'l Joint Research
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[Presentation] Identification of Emetine as a Novel Therapeutic Agent for Pulmonary Hypertension in Rats -High-throughput Screening of 5,562 Compounds-2018
Author(s)
Abdul Hai Siddique M, Satoh K, Kurosawa R, Elias-Al-Mamun M, Kikuchi N, Omura J, Satoh T, Nogi M, Sunamura S, Shimokawa H.
Organizer
World Symposium on Pulmonary Hypertension (2018年2月27～3月1日, Nice, France)
Related Report
Int'l Joint Research
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