Study of principal elemental odors and cell sensors functionally expressing olfactory receptors
| Project/Area Number |
15H02730
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Perceptual information processing
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
Takaaki Sato 国立研究開発法人産業技術総合研究所, 生命工学領域, 上級主任研究員 (20344187)
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| Co-Investigator(Kenkyū-buntansha) |
川崎 隆史 国立研究開発法人産業技術総合研究所, バイオメディカル研究部門, 主任研究員 (60356839)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 情報センシング / 匂い / 生体機能利用 / 分子認識 / 感覚センサシステム / 人工の鼻センサ / 細胞アレイ |
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| Outline of Final Research Achievements |
In Y-maze behavioral assays, by genetic ablation of all dorsal olfactory receptors, we found an enantiomer odor discrimination paradox, where mice can detect one or both of enantiomers over a wide concentration range, but are unable to discriminate them. This fact indicates that a subset of activated receptors only enable mice to discriminate the similar odors, as evidence for hierachical elemental odor coding via feedforward inhibition. Moreover, by using urine mixture samples, we evaluated relative intensities of urinary elemental odors, resulting in individual-dependent and diet-related odors < bladder cancer < occult blood < antibiotic metabolites. In the condition of 10^-6-fold, equal occult blood-diluted urine samples, sniffer mice discriminated 11/11 patients with bladder cancer. This is a proof-of-principle study for non-invasive diagnosis of cancer-induced odors. Patent of method for odor evaluation was filed.
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Report
(4 results)
Research Products
(25 results)
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[Presentation] Differential diagnosis of bladder cancer by urine odor as a biomarker using new mouse behavioral assays.2017
Author(s)
水谷陽一,佐藤孝明,小川朋美,中尾一輝,青松透真,高橋周矢,芦田彩恵,西岡香奈里,前田晃紀,堀田瑞季,米田,内本,野々村,中西,勝岡洋治
Organizer
第78回日本癌学会
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[Presentation] 尿臭をメルクマールにY迷路を用いたマウス行動実験による膀胱癌の鑑別診断2017
Author(s)
水谷陽一,佐藤孝明,小川朋美,中尾一輝,芦田彩恵,西岡香奈里,前田晃紀,堀田瑞季,米田,野々村,勝岡洋治
Organizer
第105回日本泌尿器科学会
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