Study of the mechanisms of radiation-induced chromosome abnormalities
| Project/Area Number |
15H02821
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Risk sciences of radiation and chemicals
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
Tashiro Satoshi 広島大学, 原爆放射線医科学研究所, 教授 (20243610)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
堀越 保則 広島大学, 原爆放射線医科学研究所, 助教 (00719429)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
|
|---|
| Keywords | 放射線被ばく / 損傷ゲノム / 細胞核構造 / ゲノム修復 / 染色体異常 / 放射線 / 染色体転座 |
|---|
| Outline of Final Research Achievements |
In this study, I have published papers concerning the mechanism of RAD51 focus formation involving nuclear proteins such as LaminB, a nuclear lamina related protein, after induction of DNA damage. I have also reported the result of the long time follow-up of a patient receiving radio-iodine treatment using cytogenetical analysis and estimation of radiation effect by a cardiac CT scan using immunofluorescence analysis using anti-gH2AX antibodies. I have also performed a dynamic structural analysis of radiation-induced nuclear domains using super-resolution microscopy. We found that the shape of RAD51 foci is changed by ionizing irradiation. We are now preparing a manuscript concerning the effect of ionizing radiation on the fine structure of radiation-induced nuclear domains.
|
Report
(4 results)
Research Products
(46 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Antagonizing effect of CLPABP on the function of HuR as a regulator of ARE-containing leptin mRNA stability and the effect of its depletion on obesity in old male mouse.2016
Author(s)
Nishino T, Matsunaga R, Jikihara H, Uchida M, Maeda A, Qi G, Abe T, Kiyonari H, Tashiro S, Inagaki-Ohara K, Shimamoto F, Konishi H.
-
Journal Title
Biochim Biophys Acta.
Volume: 1861
Issue: 11
Pages: 1816-1827
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
-
-
-
-
[Journal Article] Common Variant Near HEY2 Has a Protective Effect on Ventricular Fibrillation Occurrence in Brugada Syndrome by Regulating the Repolarization Current.2016
Author(s)
Nakano Y, Ochi H, Onohara Y, Toshishige M, Tokuyama T, Matsumura H, Kawazoe H, Tomomori S, Sairaku A, Watanabe Y, Ikenaga H, Motoda C, Suenari K, Hayashida Y, Miki D, Oda N, Kishimoto S, Oda N, Yoshida Y, Tashiro S, Chayama K, Kihara Y.
-
Journal Title
Circ Arrhythm Electrophysiol.
Volume: 9(1)
Issue: 1
DOI
Related Report
Peer Reviewed
-
[Journal Article] hCAS/CSE1L regulates RAD51 distribution and focus formation for homologous recombinational repair2015
Author(s)
1.Okimoto S, Sun J, Fukuto A, Horikoshi Y, Matsuda S, Matsuda T, Ikura M, Ikura T, Machida S, Kurumizaka H, Miyamoto Y, Oka M, Yoneda Y, Kiuchi Y, Tashiro S.
-
Journal Title
Genes Cells.
Volume: 20
Issue: 9
Pages: 681-94
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Book] 最新Body CT診断2018
Author(s)
福本 航、石田万理、田代 聡
Total Pages
380
Publisher
メディカル・サイエンス・インターナショナル社
ISBN
9784895929073
Related Report
-
-
