| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
In this study, I have published papers concerning the mechanism of RAD51 focus formation involving nuclear proteins such as LaminB, a nuclear lamina related protein, after induction of DNA damage. I have also reported the result of the long time follow-up of a patient receiving radio-iodine treatment using cytogenetical analysis and estimation of radiation effect by a cardiac CT scan using immunofluorescence analysis using anti-gH2AX antibodies. I have also performed a dynamic structural analysis of radiation-induced nuclear domains using super-resolution microscopy. We found that the shape of RAD51 foci is changed by ionizing irradiation. We are now preparing a manuscript concerning the effect of ionizing radiation on the fine structure of radiation-induced nuclear domains.
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