Elucidation of enhancement mechanism of the nuclear receptor binding property of bisphenol A caused by chemical modification
| Project/Area Number |
15H02827
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Kyushu University |
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Principal Investigator |
Nose Takeru 九州大学, 基幹教育院, 教授 (10301334)
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| Co-Investigator(Kenkyū-buntansha) |
巣山 慶太郎 九州大学, 基幹教育院, 助教 (60707222)
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| Research Collaborator |
Matsushima Ayami
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2018: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | ビスフェノール / 核内受容体 / 内分泌攪乱 / 毒性 / 内分泌かく乱 / 細胞毒性 / 細胞死 / ハロゲン化化合物 / ハロゲン結合 / 内分泌撹乱 / ビスフェノールA / ハロゲン / 環境 / 環境対応 |
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| Outline of Final Research Achievements |
Using chemical, biochemical, and computational chemistry methods, the risk of halogenation on bisphenol A via nuclear receptors was investigated. As a result, the binding property and transcriptional activity were changed depending on the balance of the enhancement of the chemical bond via the induced halogen atom(s) and the steric hindrance caused by the atomic size of the halogen atom(s).It was also shown that the activity of the bisphenol analogues (agonist activity, antagonist activity, inverse agonist activity, or inverse antagonist activity) are changed by the halogenation. In addition, it was revealed that halogenation induces cytotoxicity to BPA.
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| Academic Significance and Societal Importance of the Research Achievements |
近年、使用量が増大している新世代ビスフェノールのリスク、特に、ハロゲン化のリスクを本研究では検討し、ハロゲン化が受容体を介した活性を変化させること、さらに、細胞毒性を引き起こすことが見いだされた。これは、ハロゲン化が予期しない健康被害を引き起こす可能性を示しており、機能性を追求する材料開発と同時にそのリスクについても一層深く調査していく必要性があることを示した。
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Report
(5 results)
Research Products
(18 results)
