Effects of S-equol on the development of of type 2 diabetes mellitus
| Project/Area Number |
15H02900
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
Inui Hiroshi 大阪府立大学, 総合リハビリテーション学研究科, 教授 (20193568)
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| Co-Investigator(Kenkyū-buntansha) |
原田 直樹 大阪府立大学, 生命環境科学研究科, 講師 (00529141)
甲斐 建次 大阪府立大学, 生命環境科学研究科, 講師 (40508404)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
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| Keywords | S-エクオール / 膵β細胞 / 糖尿病 / cAMP/PKAシグナル / ストレプトゾトシン / エクオール / Gタンパク質共役型受容体 / 2型糖尿病 / インスリン / GPCR / PKAシグナル / 大豆イソフラボン / プロテインキナーゼA |
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| Outline of Final Research Achievements |
In the present study, we show that S-equol increased pancreatic beta-cell growth, viability, and insulin secretion through activation of G-protein coupled receptor (Gs class). Administration of S-equol suppressed against streptozotocin-induced hyperglycemia by preserving beta-cell mass in mice. These results suggest that S-equol may be useful for an anti-type 2 diabetic agent.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Inhibitory effects of Eucalyptus and Banaba leaf extracts on nonalcoholic steatohepatitis induced by a high-fructose/high-glucose diet in rats2015
Author(s)
Yoshihisa Takahashi, Keiichiro Sugimoto, Yurie Soejima, Arisa Kumagai, Tatsuki Koeda, Aiko Shojo, Kazuya Nakagawa, Naoki Harada, Ryoichi Yamaji, Hiroshi Inui, Toshikazu Yamanouchi, and Toshio Fukusato.
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Journal Title
Biomed. Res. Int.
Volume: 2015
Pages: 296207-296207
DOI
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