Artificial control of disease progression by a new heating and cooling system
| Project/Area Number |
15H03000
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Gunma University |
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Principal Investigator |
Shibasaki Koji 群馬大学, 大学院医学系研究科, 准教授 (20399554)
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| Co-Investigator(Kenkyū-buntansha) |
鈴木 倫保 山口大学, 大学院医学系研究科, 教授 (80196873)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
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| Keywords | TRPV4 / TRPV2 / 脳内温度 / てんかん / 浮腫 / グリア / アストロサイト / 網膜剥離 / 温度 / 神経 / 海馬 / パーキンソン病 / 温度操作 / 冷却 / デバイス / ＴＲＰＶ４ |
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| Outline of Final Research Achievements |
We have clearly revealed that a thermo-sensor TRPV4 (activated above 34°C) is activated by physiological temperature in hippocampal neurons and thereby controls their excitability. Therefore, if local brain temperature could dynamically elevate depending on the neuronal activities, a thermo-sensor TRPV4 can enhance electrical excitability in neurons, and might lead to hyperexcitability. In this study, we focused on epilepsy, since it was caused by hyperexcitability of neurons. We generated a model of partial epilepsy in wild type (WT) or TRPV4KO mice, and measured electroencephalogram (EEG). The frequencies of epileptic EEG in WT mice were significantly larger than those in TRPV4KO mice. These results strongly indicate that TRPV4 activation is involved in disease progression of epilepsy. We expected that the disease progression enhanced hyperexcitability, and lead to hyperthermia in the epileptogenic zones.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Shp2 in forebrain neurons regulates synaptic plasticity, locomotion, and memory formation in mice2015
Author(s)
Kusakari S, Saitow F, Ago Y, Shibasaki K, Sato-Hashimoto, M., Matsuzaki, Y., Kotani T, Murata Y, Hirai H, Matsuda T, Suzuki H, Matozaki T, Ohnishi H
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Journal Title
Mol. Cell. Biol.
Volume: 35
Issue: 9
Pages: 1557-1572
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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