Clarification of structure-function correlation of silk fibroin for Next Generation Heart Valve
| Project/Area Number |
15H03020
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
NAKAZAWA Yasumoto 東京農工大学, 工学(系)研究科(研究院), 准教授 (20456255)
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| Co-Investigator(Renkei-kenkyūsha) |
KUROBE Hirotsugu 徳島大学, 大学院医歯薬学研究部, 特任講師 (30380083)
ASANO Atsushi 防衛大学校, 応用化学科, 教授 (90545972)
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| Research Collaborator |
MURAKAMI Tomoaki 東京農工大学, 大学院農学研究院, 助教
TARA Shuhei 日本医科大学, 附属病院, 講師
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
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| Keywords | 組織工学 / 心臓弁 / シルクフィブロイン / 再生医学 / 細胞・組織 / 生体材料 |
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| Outline of Final Research Achievements |
Silk fibroin (SF) is a biodegradable material, however, it lacks the elasticity required for a artificial heart valves. Polyurethane (PU) and polycarbonate(PC) are well-known for elastomer so this study focused on a SF-PU or SF-PC composite materials for tissue engineering materials, especially regeneration heart valves.
As a result, we succeeded in nano-fiber sheets material. And each materials were able to exhibit good results in terms of improvement in physical properties, inhibition of inflammation and calcification, and tissue regeneration. However, it was found that infiltration of cells and tissues into the interior of the sheet was slight by animal implantation experiments.Continuing this research, we aim to propose new materials applicable to absorbable heart valves in the future.
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Report
(4 results)
Research Products
(67 results)
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[Journal Article] Development of a new surgical sheet containing both silk fibroin and thermoplastic polyurethane for cardiovascular surgery2018
Author(s)
Shimada, R., Konishi, H., Ozawa, H., Katsumata, T., Tanaka, R., Nakazawa, Y., Nemoto S.
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Journal Title
Surgery Today
Volume: 48
Issue: 5
Pages: 486-494
DOI
Related Report
Peer Reviewed
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[Journal Article] Solid-state NMR studies for the development of non-woven biomaterials based on silk fibroin and polyurethane2017
Author(s)
Nakazawa, C. T., Higuchi, A., Asano, A., Kameda, T., Aytemiz, D., Nakazawa, Y.
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Journal Title
Polymer Journal
Volume: 49
Issue: 7
Pages: 583-586
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Packing Arrangement of 13C Selectively Labeled Sequence Model Peptides of Samia cynthia ricini Silk Fibroin Fiber studied by Solid-state NMR2017
Author(s)
Asakura, T., Miyazawa, K., Taseia, Y., Kametani, S., Nakazawa, Y,. Aoki, A., Naito, A.
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Journal Title
Phys. Chem. Chem. Phys.
Volume: 印刷中
Related Report
Peer Reviewed
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[Presentation] Development of angiogenic peptides /silk fibroin sheet for coronary vascularization2015
Author(s)
○Kohdai Takahama, Kazumi shimada, Ryo Shimada, Aki Yonezawa, Ryo Tanaka, Shintaro Nemoto,Yoichi TOMINAGA, Tsunenori Kameda, Yasumoto Nakazawa
Organizer
2015 環太平洋国際化学会議 (Pacifichem2015)
Place of Presentation
Honolulu, HI, USA
Year and Date
2015-12-18
Related Report
Int'l Joint Research
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