| Budget Amount *help |
¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2017: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2016: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
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| Outline of Final Research Achievements |
Hydroxyapatite (HAp) are one of the important key materials in the field of biomaterials. Recently, immunotherapy without side effects has been expected as a novel medical treatment for a cancer. In order to create the novel cell-culture substrates for enhancing the activity of immune cells, we have developed the two types “immunoceramics” on the bases of i) boron-containing apatite (BAp) with BO2 groups and ii) HAp ceramics surface-modified with inositol phosphate (IP6) (hereafter, IP6-HAp ceramics). Splenocytes derived from the spleen of mouse were seeded on these immnoceramics to examine the activation ability using a flow cytometry. The results showed that the populations of splenocytes with the immunoceramics were higher than that of the splenocytes with the HAp ceramics as a control. The present two immunoceramics may be expected as key materials for next-generation immunotherapy for a cancer.
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