The effective training and the mechanisms for recovery from muscle atrophy
| Project/Area Number |
15H03042
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
曽我部 正博 名古屋大学, 医学系研究科, 特任教授 (10093428)
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| Co-Investigator(Renkei-kenkyūsha) |
MURAKAMI Taro 至学館大学, 健康科学部, 教授 (10252305)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
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| Keywords | 筋萎縮 / 理学療法 / 筋衛星細胞 / 筋肥大 / 理学療法学 / リハビリテーション / 医学・福祉 / 筋 |
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| Outline of Final Research Achievements |
We aimed to determine the optimum training intensity for muscle atrophy. Muscle recovery assessed by maximal isometric contraction and myofiber cross‐sectional areas (CSAs) were facilitated at 40% and 60% maximum contraction strength (MC). Activation of myogenic satellite cells and a marked increase in myonuclei were observed at 40%, 60% MC. On the other hand, we aimed to examine the accumulation or degradation of damaged proteins after contractive activity and the following inactivity in cultured myotube. 2 days of repeated muscle contraction induced myotube hypertrophy. Damaged proteins were accumulated during the hypertrophy. When the contractile activities were stopped, autophagy was immediately activated and the damaged proteins were removed. Muscle inactive state is necessary to remove damaged proteins accumulated by repeated muscle contraction.
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Report
(4 results)
Research Products
(16 results)
