Development of the strategy to control obesity among people with physical disabilities.

• Project/Area Number: 15H03048
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: National Rehabilitation Center for Persons with Disabilities
• Principal Investigator: Akai Masami 国立障害者リハビリテーションセンター(研究所), 研究所, 研究所顧問 (80143452)
• Co-Investigator(Kenkyū-buntansha): 緒方 徹 国立障害者リハビリテーションセンター(研究所), その他部局等, 障害者健康増進・運動医科学支援センター長 (00392192)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000); Fiscal Year 2017: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
• Keywords: 慢性炎症 / 二次障害 / 耐糖能異常

Outline of Final Research Achievements

For the people with physical disabilities, the maintenance of body weight by physical exercise is difficult. In the current study we aimed to reveal the relation between immobilized limb and systemic metabolism. The mouse model of spinal cord injury showed deterioration in glucose tolerance. In addition, we found that the inflammatory reaction occurs within the immobilized muscles though the activation of macrophages. Our results suggest that the mobilization of disabled muscle, even by passively, may provide benefit for physical fitness control for those patients.

Research Products

• [Journal Article] Oligodendrocyte Progenitor Cells Directly Utilize Lactate for Promoting Cell Cycling and Differentiation (2017)
  • Author(s): Ichihara Y, Doi T, Ryu Y, Nagao M, Sawada Y, Ogata T
  • Journal Title: J Cell Physiol Volume: 232 Issue: 5 Pages: 986-995
  • DOI: 10.1002/jcp.25690
  • Peer Reviewed / Open Access
• [Journal Article] The swimming test is effective for evaluating spasticity after contusive spinal cord injury (2017)
  • Author(s): Ryu Y, Ogata T, Nagao M, Kitamura T, Morioka K, Ichihara Y, Doi T, Sawada Y, Akai M, Nishimura R, Fujita N
  • Journal Title: PLoS One Volume: 12 Issue: 2 Pages: e0171937-e0171937
  • DOI: 10.1371/journal.pone.0171937
  • Peer Reviewed / Open Access / Acknowledgement Compliant