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Central neural circuits responsible for generating central command during exercise

Research Project

Project/Area Number 15H03061
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Developmental mechanisms and the body works
Research InstitutionHiroshima University

Principal Investigator

MATSUKAWA KANJI  広島大学, 医歯薬保健学研究科(保), 教授 (90165788)

Co-Investigator(Kenkyū-buntansha) 丹 信介  山口大学, 教育学部, 教授 (00179920)
小峰 秀彦  国立研究開発法人産業技術総合研究所, 情報・人間工学領域, 研究チーム長 (10392614)
定本 朋子  日本女子体育大学, 体育学部, 教授 (30201528)
長尾 正崇  広島大学, 医歯薬保健学研究科(医), 教授 (80227991)
相澤 秀紀  広島大学, 医歯薬保健学研究科(医), 教授 (80391837)
川真田 聖一  広島大学, 医歯薬保健学研究院(保), 教授 (30127641)
Co-Investigator(Renkei-kenkyūsha) LIANG Nan  広島大学, 大学院医歯薬保健学研究科, 助教 (70512515)
ENDO Kana  広島大学, 大学院医歯薬保健学研究科, 助教 (60584696)
KUROSE Tomoyuki  広島大学, 大学院医歯薬保健学研究科, 助教 (20363054)
Research Collaborator ISHII Kei  , 学振PD特別研究員
ASAHARA Ryota  , 学振PD特別研究員
IDESAKO Mitsuhiro  広島大学, 大学院生
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Keywords随意運動 / 運動の精神イメージ / 筋交感神経と筋血流量 / 交感神経コリン作動性血管拡張 / セントラルコマンドの発現 / 大脳皮質前頭前野 / 大脳皮質運動野 / 中枢神経機構 / 筋交感コリン作動性神経と筋血流量 / 近赤外分光法(NIRS) / 大脳皮質脳活動の計測 / リハビリテーション / 中枢神経性循環調節 / コリン作動性交感神経 / 免疫組織化学染色
Outline of Final Research Achievements

We have found using near-infrared spectroscopy that prefrontal oxygenated- hemoglobin (Oxy-Hb) concentration, measured as index of regional cerebral blood flow, increased 5-10 s prior to the onset of arbitrary ergometer exercise in a laboratory and freely-moving walking on the floor. Such increase in prefrontal Oxy-Hb was, however, absent when exercise was abruptly started by a verbal cue. The increase in prefrontal Oxy-Hb observed prior to the onset of voluntary exercise was early enough for autonomic control of the cardiovascular system at the onset of voluntary exercise. Mental imagery of the overground walking incresaed prefrofontal oxygenation to the same exent as in the case of actual walking. Thus it is suggested that the prefrontal cortex may play a role in contributing to generation of central command.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (47 results)

All 2018 2017 2016 2015 Other

All Journal Article (13 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 12 results,  Open Access: 2 results,  Acknowledgement Compliant: 9 results) Presentation (27 results) (of which Int'l Joint Research: 5 results,  Invited: 2 results) Book (2 results) Remarks (5 results)

  • [Journal Article] Decreased prefrontal oxygenation elicited by stimulation of limb mechanosensitive afferents during cycling exercise2018

    • Author(s)
      Asahara Ryota、Matsukawa Kanji
    • Journal Title

      American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

      Volume: 印刷中 Issue: 2 Pages: R230-R240

    • DOI

      10.1152/ajpregu.00454.2017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Incremental rate of prefrontal oxygenation determines performance speed during cognitive Stroop test: the effect of ageing2018

    • Author(s)
      Endo Kana、Liang Nan、Idesako Mitsuhiro、Ishii Kei、Matsukawa Kanji
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 印刷中 Issue: 6 Pages: 807-824

    • DOI

      10.1007/s12576-018-0599-3

    • NAID

      40021720582

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prefrontal oxygenation correlates to the responses in facial skin blood flows during exposure to pleasantly charged movie2017

    • Author(s)
      Matsukawa Kanji、Endo Kana、Asahara Ryota、Yoshikawa Miho、Kusunoki Shinya、Ishida Tomoko
    • Journal Title

      Physiological Reports

      Volume: 5 Issue: 21

    • DOI

      10.14814/phy2.13488

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Central command increases muscular oxygenation of the non-exercising arm at the early period of voluntary one-armed cranking2017

    • Author(s)
      Ishii K, Matsukawa K, Asahara R, Liang N, Endo K, Idesako M, Michioka K, Sasaki Y, Hamada H, Yamashita K, Watanabe T, Kataoka T, Takahashi M
    • Journal Title

      Physiological Reports

      Volume: 5 Issue: 7 Pages: 1-18

    • DOI

      10.14814/phy2.13237

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Facial skin blood flow responses to exposures to emotionally charged movies2017

    • Author(s)
      Matsukawa K, Endo K, Ishii K, Ito M, Liang N
    • Journal Title

      Journal of Physiological Sciences

      Volume: 印刷中 Issue: 2 Pages: 1-16

    • DOI

      10.1007/s12576-017-0522-3

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Central command does not supress baroreflex control of cardiac sympathetic nerve activity at the onset of spontaneous motor activity in the decerebrate cat2016

    • Author(s)
      Matsukawa K, Ishii K, Asahara R, Idesako M
    • Journal Title

      Journal of Applied Physiology

      Volume: 121 Issue: 4 Pages: 932-943

    • DOI

      10.1152/japplphysiol.00299.2016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The prefrontal oxygenation and ventilatory responses at start of one-legged cycling exercise have relation to central command2016

    • Author(s)
      Asahara R, Matsukawa K, Ishii K, Liang N, Endo K
    • Journal Title

      Journal of Applied Physiology

      Volume: 121 Issue: 5 Pages: 1115-1126

    • DOI

      10.1152/japplphysiol.00401.2016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Central command generated prior to arbitrary motor execution induces muscle vasodilatation at the beginning of dynamic exercise.2016

    • Author(s)
      Ishii K, Matsukawa K, Liang N, Endo K, Idesako M, Asahara R, Kadowaki A, Wakasugi R, Takahashi M
    • Journal Title

      J Appl Physiol

      Volume: 21 Issue: 12 Pages: 1424-1433

    • DOI

      10.1152/japplphysiol.00103.2016

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cardiac parasympathetic outflow during dynamic exercise in humans estimated from power spectrum analysis of PP interval variability2016

    • Author(s)
      Takahashi M, Nakamoto T, Matsukawa K, Ishii K, Watanabe T, Sekikawa K, Hamada H
    • Journal Title

      Experimental Physiology

      Volume: In press Issue: 3 Pages: 397-409

    • DOI

      10.1113/ep085420

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Increased oxygenation of the cerebral prefrontal cortex prior to the onset of voluntary exercise in humans2015

    • Author(s)
      Kanji Matsukawa, Kei Ishii, Nan Liang, Kana Endo, Ryo Ohtani, Tomoko Nakamoto, Rie Wakasugi, Akito Kadowaki, Hidehiko Komine.
    • Journal Title

      Journal of Applied Physiology

      Volume: 119 Issue: 5 Pages: 452-462

    • DOI

      10.1152/japplphysiol.00406.2015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Differential contribution of aortic and carotid sinus baroreflexes to control of heart rate and renal sympathetic nerve activity2015

    • Author(s)
      Ishii K, Idesako M, Matsukawa K
    • Journal Title

      Journal of Physiological Sciences

      Volume: 65 Issue: 5 Pages: 471-480

    • DOI

      10.1007/s12576-015-0387-2

    • NAID

      40020576573

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Stimulation of the mesencephalic ventral tegmental area blunts the sensitivity of cardiac baroreflex in decerebrate cats2015

    • Author(s)
      Matsukawa K, Ishii K, Ishida T, Nagai A, Liang N
    • Journal Title

      Auton Neurosci

      Volume: 189 Pages: 16-24

    • DOI

      10.1016/j.autneu.2014.12.005

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Facial skin blood flow response during exposure to emotionally-charged movie2015

    • Author(s)
      Ishii K, Ito M, Endo K, Liang N, Idesako M, Matsukawa K
    • Journal Title

      FASEB Journal

      Volume: 29

    • NAID

      40021480165

    • Related Report
      2015 Annual Research Report
    • Acknowledgement Compliant
  • [Presentation] A limb mechanoreflex decreases the prefrontal oxygenation during motor-driven passive cycling in humans.2018

    • Author(s)
      Asahara R, Hashiguchi Y, Matsukawa K.
    • Organizer
      第95回日本生理学会大会、高松市、2018年3月.
    • Related Report
      2017 Annual Research Report
  • [Presentation] Feedforward control of the cardiovascular system during exercise: insight from animal and human studies.2018

    • Author(s)
      Asahara R, Matsukawa K.
    • Organizer
      第95回日本生理学会大会、高松市、2018年3月.
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Responses in facial skin blood flow and prefrontal oxygenation during exposure to emotionally charged negative and positive odors.2018

    • Author(s)
      Endo K, Yoshikawa M, Matsukawa K, Nakamura A, Nakamura T.
    • Organizer
      第95回日本生理学会大会、高松市、2018年3月.
    • Related Report
      2017 Annual Research Report
  • [Presentation] Changes in human prefrontal activity during exposure to emotionally-charged movies: a preliminary study by simultaneous recordings of NIRS and fMRI.2018

    • Author(s)
      Liang N, Harada T, Sasaoka T, Yamawaki S, Endo K, Matsukawa K.
    • Organizer
      第95回日本生理学会大会、高松市、2018年3月.
    • Related Report
      2017 Annual Research Report
  • [Presentation] Prefrontal oxygenation correlates to the responses in facial skin blood flows during exposure to pleasantly-charged movie.2018

    • Author(s)
      Matsukawa K, Endo K, Yoshikawa M, Asahara R.
    • Organizer
      第95回日本生理学会大会、高松市、2018年3月.
    • Related Report
      2017 Annual Research Report
  • [Presentation] Symposium 9: Increased oxygenation of the prefrontal cortex prior to the onset of exercise has relation to central command2017

    • Author(s)
      Matsukawa K, Ishii K, Asahara R, Endo K, Liang N
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松市
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] The cerebral prefrontal oxygenation during first and third person imagery of cycling exercise2017

    • Author(s)
      Liang N, Arikawa M, Satake Y, Endo K, Asahara R, Matsukawa K
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松市
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] Effect of motor imagery on blood flow in leg skeletal muscle in elderly subjects2017

    • Author(s)
      Endo K, Ishii K, Asahara R, Doi S, Linag N, Matsukawa K
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松市
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] Increased oxygenation of the dorsolateral prefrontal cortex prior to the onset of voluntary one-armed cranking2017

    • Author(s)
      Ishii K, Matsukawa K, Liang N
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松市
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] Effect of endurance exercise on the centrally-induced muscle vasodilatation during one-legged cycling2017

    • Author(s)
      Asahara R, Matsukawa K, Shintaku T
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松市
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] Effect of endurance training on the centrally-induced muscle vasodilatation during one-legged cycling.2017

    • Author(s)
      Asahara R, Matsukawa K, Shintaku T.
    • Organizer
      Experimental Biology 2017, Chicago, USA, 22-26 April, 2017.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Facial skin blood flow decreases during exposure to pleasantly charged movie in humans.2017

    • Author(s)
      Asahara R, Endo K, Yoshikawa M, Kusunoki S, Matsukawa K.
    • Organizer
      The International Society for Autonomic Neuroscience 2017, Nagoya, Japan, 30 August-2 September, 2017.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reduction in prefrontal oxygenation during exposure to positively-charged movie in humans2017

    • Author(s)
      Endo K, Yoshikawa M, Kusunoki S, Asahara R, Matsukawa K.
    • Organizer
      The International Society for Autonomic Neuroscience 2017, Nagoya, Japan, 30 August-2 September, 2017.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 自発運動開始時おける前頭前野の酸素化ヘモグロビン濃度の増加は運動強度と比例しない.2017

    • Author(s)
      浅原亮太、松川寛二、梁楠、遠藤加菜.
    • Organizer
      第72回日本体力医学大会、松山市、2017年9月.
    • Related Report
      2017 Annual Research Report
  • [Presentation] ラット皮質前頭前野の電気刺激は副交感神経を介する口唇領域の血管拡張を引き起こす.2017

    • Author(s)
      浅原亮太、松川寛二.
    • Organizer
      第69回日本生理学会中国四国地方会、徳島市、2017年10月.
    • Related Report
      2017 Annual Research Report
  • [Presentation] 快感情の映像刺激は皮質前頭前野の酸素化ヘモグロビン濃度を減少させる.2017

    • Author(s)
      松川寛二、遠藤加菜、吉川美穂、.浅原亮太、楠信哉.
    • Organizer
      第69回日本生理学会中国四国地方会、徳島市、2017年10月.
    • Related Report
      2017 Annual Research Report
  • [Presentation] 嗅覚刺激による快・不快の情動変化が顔面皮膚血流量および前頭葉ヘモグロビン動態に与える影響2017

    • Author(s)
      遠藤加菜、吉川美穂、松川寛二、中村明朗、中村哲也.
    • Organizer
      第51回日本味と匂学会、神戸市、2017年9月
    • Related Report
      2017 Annual Research Report
  • [Presentation] Central command hypothesis: from cerebral prefrontal cortex to blood vessels of skeletal muscle2016

    • Author(s)
      Matsukawa K
    • Organizer
      The 6th International Sports Science Network Forum in Nagano 2016
    • Place of Presentation
      松本市
    • Year and Date
      2016-11-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The prefrontal oxygenation at the onset of unrestrained overground walking in humans2016

    • Author(s)
      Asahara R, Matsukawa K, Liang N, Endo K, Ishii K
    • Organizer
      The 6th International Sports Science Network Forum in Nagano 2016
    • Place of Presentation
      松本市
    • Year and Date
      2016-11-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 運動開始時における前頭前野酸素化ヘモグロビン濃度の増加と換気応答の関連2016

    • Author(s)
      浅原亮太、松川寛二、石井圭、梁楠、遠藤加菜
    • Organizer
      第71回日本体力医学会大会
    • Place of Presentation
      盛岡市
    • Year and Date
      2016-09-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] 運動イメージによる呼吸循環系の活性化2016

    • Author(s)
      石井圭、松川寛二、梁楠、遠藤加菜、浅原亮太、井手迫光弘
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌市
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] ヒトの随意運動開始時における前頭前野酸化Hb濃度と呼気終末炭酸ガス濃度との関連2016

    • Author(s)
      浅原亮太、松川寛二、石井圭、梁楠、遠藤加菜
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌市
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 視覚刺激による快・不快の情動変化が顔面皮膚血流量に与える影響2016

    • Author(s)
      遠藤加菜、伊藤百花、川原舞、小畑菜央、石井圭、梁楠、浅原亮太、松川寛二
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌市
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 平地とトレッドミル歩行時の大脳皮質興奮性の変化についてーポータブルfNIRSを用いた解析2016

    • Author(s)
      梁楠、浅原亮太、石井圭、遠藤加菜、松川寛二
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌市
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 心臓交感神経活動は除脳ネコの自発運動時にみられる動脈血圧受容器ー心拍数反射の抑制に関与しない2016

    • Author(s)
      松川寛二、石井圭、浅原亮太、井手迫光弘、石田知子
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌市
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 視覚刺激による快・不快の情動反応が顔面皮膚血流量に及ぼす影響2015

    • Author(s)
      遠藤加菜、伊藤百花、石井圭、梁楠、松川寛二
    • Organizer
      第67回日本生理学会中国四国地方会
    • Place of Presentation
      米子市
    • Year and Date
      2015-10-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 無拘束状態での床歩行時とトレッドミル歩行時にみられる大脳皮質運動野活動2015

    • Author(s)
      浅原亮太、松川寛二、石井圭、梁楠、遠藤加菜
    • Organizer
      第67回日本生理学会中国四国地方会
    • Place of Presentation
      米子市
    • Year and Date
      2015-10-24
    • Related Report
      2015 Annual Research Report
  • [Book] 解剖学・生理学・運動学に基づく動作分析: 第1章 2. 生理学の概要2018

    • Author(s)
      松川寛二
    • Total Pages
      47
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2017 Annual Research Report
  • [Book] 生理学: 第5章 筋肉・運動の生理2016

    • Author(s)
      松川寛二
    • Total Pages
      26
    • Publisher
      理工図書(株)
    • Related Report
      2016 Annual Research Report
  • [Remarks] 広島大学医学部保健学科・生理機能情報科学研究室のオリジナルホームページ

    • URL

      http://home.hiroshima-u.ac.jp/matsulab/

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Remarks] 広島大学医学部・生理機能情報科学研究室

    • URL

      http://home.hiroshima-u.ac.jp/med/research/lab/health/Integrative_Physiology

    • Related Report
      2017 Annual Research Report
  • [Remarks] 広島大学医学部・生理機能情報科学研究室

    • URL

      http://home.hiroshima-u.ac.jp/med/reserach/lab/health/Integrative_Physiology/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 広島大学大学院医歯薬保健学研究院・基礎生命科学部門・生理機能情報科学研究室ホームページ

    • URL

      http://home.hiroshima-u.ac.jp/matsulab/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 広島大学医学部・生理機能情報科学研究室ホームページ

    • URL

      http://hiroshima-u.jp/med/research/lab/health/Integrative_Physiology

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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