Development of exercise and diet prescription considering the genetic risk score of sarcopenia
| Project/Area Number |
15H03099
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
Sanada Kiyoshi 立命館大学, スポーツ健康科学部, 教授 (50421227)
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| Co-Investigator(Kenkyū-buntansha) |
村上 晴香 国立研究開発法人医薬基盤・健康・栄養研究所, 国立健康・栄養研究所 身体活動研究部, 室長 (20344880)
宮地 元彦 国立研究開発法人医薬基盤・健康・栄養研究所, 国立健康・栄養研究所 身体活動研究部, 部長 (60229870)
家光 素行 立命館大学, スポーツ健康科学部, 教授 (90375460)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Keywords | サルコペニア / 医療・福祉 / 運動 / 食事 / 遺伝子 |
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| Outline of Final Research Achievements |
In this study, we performed genome-wide association analyses (GWAS) of CNV for sarcopenia in 506 Japanese subjects. Appendicular muscle mass (AMM) was measured by dual-energy X-ray absorptiometry. Reference values for classes 2 sarcopenia (skeletal muscle index ; AMM/height2, kg/m2) in each sex were defined as values two standard deviations below the sex-specific means of reference values obtained in our cohort database from young adults aged 18-40 years（Sanada et al Eur J Appl Physiol, 2010）. The reference values for class 2 sarcopenia were 6.87 kg/m2 in men and 5.46 kg/m2 in women. We analyzed 6 million SNPs using HumanOmni-Quad BeadChip (Illumina co., ltd). Consequently, 49SNPs were detected to be associated with sarcopenia (p<1.00×10-5). This study predicts regulatory networks of ESR1 and MEGF10 in sarcopenia using bioinformatics analysis. In summary, our study suggested two novel CNVs and the related genes that may contribute to variation in Japanese sarcopenia.
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Report
(4 results)
Research Products
(87 results)
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[Journal Article] Effect of resistance training using bodyweight in the elderly:Comparison of resistance exercise movement between slowand normal speed movement.2015
Author(s)
Wtanabe, Y., Tanimoto, M., Oba, N., Sanada, K., Miyachi, M., Ishii, N.
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Journal Title
Geriatric and Gerontology International
Volume: 15
Issue: 12
Pages: 1270-1277
DOI
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Peer Reviewed / Open Access
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[Journal Article] A missense single nucleotide polymorphism, V114I of the Werner syndrome gene, is associated with risk of osteoporosis and femoral fracture in the Japanese2015
Author(s)
Zhou H, Mori S, Tanaka M, Sawabe M, Arai T, Muramatsu M, Mieno MN, Shinkai S, Yamada Y, Miyachi M, Murakami H, Sanada K, Ito H.
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Journal Title
Journal of Bone and Mineral Metabolism.
Volume: ‐
Issue: 6
Pages: 694-700
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] サルコペニア肥満の簡易評価法2016
Author(s)
真田樹義、宮地元彦、石井好二郎、浅原哲子
Organizer
第3回日本サルコペニア・フレイル研究会研究発表会
Place of Presentation
今池ガスビル（愛知県・名古屋市）
Year and Date
2016-11-06
Related Report
Invited
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[Presentation] サルコペニア肥満の評価法2016
Author(s)
真田樹義、宮地元彦、石井好二郎、浅原哲子
Organizer
第71回日本体力医学会大会
Place of Presentation
いわて県民情報交流センター（岩手県・盛岡市）
Year and Date
2016-09-24
Related Report
Invited
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[Book] Relationship of Cardiorespiratory Fitness and Obesity Genes to Metabolic Syndrome in Adult Japanese Men2015
Author(s)
Kiyoshi Sanada, Motoyuki Iemitsu, Haruka Murakami, Ryoko Kawakami, Yuko Gando, Hiroshi Kawano, Katsuhiko Suzuki, Mitsuru Higuchi, Motoyuki Miyachi. Editor in Chief:Kazuyuki Kanosue, Editors:Satomi Oshima, Zhen-Bo Cao, Koichiro Oka
Total Pages
336
Publisher
Springer
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