| Budget Amount *help |
¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
To clarify the possibility of the preventive effects of exercise habits on metabolic syndrome through a change in the intestinal microbiota, exercise-induced changes in intestinal microbiota in mice lacking Toll-like receptor 5 (TLR5) ), which develop metabolic syndrome, were investigated. The indicators of metabolic syndrome, which were observed in the gene knockout mice were attenuated by treatment of wheel-running. In addition, the knockout mice treated wheel-running showed both inhibition of chronic inflammation and changes in intestinal microbiota. These results suggest that voluntary exercise may be able to control the regulation of intestinal microbiota via TLR5 associated with deterioration of the metabolic syndrome.
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