Protective impact of exercise on appearance of metabolic syndrome via changes in gut microbiota
| Project/Area Number |
15H03102
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Kawasaki University of Medical Welfare |
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Principal Investigator |
Yano Hiromi 川崎医療福祉大学, 医療技術学部, 教授 (20248272)
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 自発運動 / TLR5遺伝子欠損マウス / 高脂肪食 / 肥満症 / F/B比 / TLR5遺伝子欠損 / 腸内細菌叢 / 次世代シーケンス法 / 微生物 / 便移植法 / 腸内細菌 / メタボリックシンドローム / 肥満 / 慢性炎症 / ＴＬＲ５遺伝子欠損 / TLR5 / 次世代シーケンス |
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| Outline of Final Research Achievements |
To clarify the possibility of the preventive effects of exercise habits on metabolic syndrome through a change in the intestinal microbiota, exercise-induced changes in intestinal microbiota in mice lacking Toll-like receptor 5 (TLR5) ), which develop metabolic syndrome, were investigated. The indicators of metabolic syndrome, which were observed in the gene knockout mice were attenuated by treatment of wheel-running. In addition, the knockout mice treated wheel-running showed both inhibition of chronic inflammation and changes in intestinal microbiota. These results suggest that voluntary exercise may be able to control the regulation of intestinal microbiota via TLR5 associated with deterioration of the metabolic syndrome.
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| Academic Significance and Societal Importance of the Research Achievements |
メタボリックシンドローム予防効果を検討した便移植実験例は報告されていない。しかし、運動習慣を有するドナーマウスからの便移植による、レシピエントマウスの体重抑制現象を観察した。便移植による肥満が解消されるという結果は、運動習慣による腸内細菌叢の改善効果を示唆するという点で、意義ある知見かもしれない。今後、アスリートの腸内細菌叢研究、さらにはサプリメントとして健康産業界へ参入してくる将来への可能性を予感させるものと考える。
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Report
(5 results)
Research Products
(38 results)
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[Presentation] Gut microflora diversity is induced by resistance training in aged mice, but its acquired diversity might not be contributed with the high physical performance.2018
Author(s)
Yano, H., Horii, N., Kremenik, M.J., Aoki, T., Uchida, M., Iemitsu, M., Oyanagi, E.
Organizer
23rd Annual Congress of the European College of Sport Science
Related Report
Int'l Joint Research
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[Presentation] 運動と腸内細菌叢2016
Author(s)
矢野博己
Organizer
第50回川崎医療福祉学会研究集会
Place of Presentation
川崎医療福祉大学(岡山県倉敷市松島）
Year and Date
2016-06-22
Related Report
Invited
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[Presentation] Voluntary exercise attenuates obesity and systemic inflammation by alteration of gut microbiota in TLR5-deficient mice.2016
Author(s)
Yano, H., Uchida, M., Oyanagi, E., Iemitsu, M., Kremenik, M.J., Onodera, S., Miyachi, M.
Organizer
63rd Annual Meeting of The American College of Sports Medicine
Place of Presentation
Hynes Convention Center (Boston, USA)
Year and Date
2016-06-03
Related Report
Int'l Joint Research
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[Presentation] The gut microbiota of TLR5-deficient mice display elevated voluntary physical activity.2016
Author(s)
Oyanagi, E., Uchida, M., Kremenik, M.J., Iemitsu, M., Miyachi, M., Yano, H.
Organizer
63rd Annual Meeting of The American College of Sports Medicine
Place of Presentation
Hynes Convention Center (Boston, USA)
Year and Date
2016-06-01
Related Report
Int'l Joint Research
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