Development of early diagnosis and pathology analysis system for attachment disorder
| Project/Area Number |
15H03106
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Childhood science (childhood environment science)
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| Research Institution | University of Fukui |
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Principal Investigator |
TOMODA AKEMI 福井大学, 子どものこころの発達研究センター, 教授 (80244135)
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| Co-Investigator(Renkei-kenkyūsha) |
FUJISAWA TAKASHI 福井大学, 子どものこころの発達研究センター, 特命講師 (90434894)
SHIMADA KOJI 福井大学, 子どものこころの発達研究センター, 特命助教 (00711128)
TAKIGUCHI SHINICHIRO 福井大学, 学術研究院医学系部門(附属病院部), 特命助教 (70382926)
MIZUNO YOSHIFUMI 福井大学, 学術研究院医学系部門(附属病院), 特命助教 (50756814)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2017: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Keywords | 反応性愛着障害(RAD) / アタッチメント / ADHD / 脳画像解析 / ｆMRI / 線条体 / ＡＤＨＤ / ｆＭＲＩ / 反応性愛着障害 / オキシトシン / マルトリートメント / fMRI / VBM / オキシトシン治療 |
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| Outline of Final Research Achievements |
Reactive attachment disorder (RAD) is a severe social functioning disorder associated with early childhood maltreatment, characterized by emotionally withdrawn-inhibited behavior. Previously, we reported RAD is associated with decreased ventral striatum activity during reward task. The neuropeptide oxytocin (OT) has been reported to enhance brain reward system in healthy adults. This study examined the neural effects of intranasal OT on reward processing in children and adolescents with RAD.
Twenty male children and adolescents with RAD and age- and gender-matched 28 typically developing (TD) individuals performed high and low monetary reward task during fMRI. The effects of intranasally administered OT were tested in a randomized, double-blind, placebo-controlled, within-subject, cross-over design.
We found that intranasal OT increased reward sensitivity in the striatum in RAD patients. These findings indicate that OT may promote reward processing and reward-related behavior in RAD.
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Report
(4 results)
Research Products
(138 results)
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[Journal Article] Increased anterior pelvic angle characterizes the gait of children with attention deficit/hyperactivity disorder (ADHD).2017
Author(s)
Naruse H, Fujisawa TX, Yatsuga C, Kubota M, Matsuo H, Takiguchi S, Shimada S, Imai Y, Hiratani M, Kosaka H, Tomoda A*.
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Journal Title
PLoS One
Volume: 12(1)
Issue: 1
Pages: e0170096-e0170096
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Oxytocin efficacy is modulated by dosage and oxytocin receptor genotype in young adults with high-functioning autism: a 24-week randomized clinical trial.2016
Author(s)
Kosaka H, Okamoto Y, Munesue T, Yamasue H, Inohara K, Fujioka T, Anme T, Orisaka M, Ishitobi M, Jung M, Fujisawa TX, Tanaka S, Arai S, Asano M, Saito DN, Sadato N, Tomoda A, Omori M, Sato M, Okazawa H, Higashida H, Wada Y.
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Journal Title
Translational Psychiatry
Volume: 6
Issue: 8
Pages: e872-e872
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Low putamen activity associated with poor reward sensitivity in childhood chronic fatigue syndrome2016
Author(s)
Mizuno, K., Kawatani, J., Tajima, K., Sasaki, A. T., Yoneda, T., Komi, M., Hirai, T., Tomoda, A., Joudoi, T., Watanabe, Y.
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Journal Title
Neuroimage: Clinical, 12: 600-606, 2016.
Volume: 12
Pages: 600-606
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Decision making processes based on social conventional rules in early adolescents with and without autism spectrum disorders.2016
Author(s)
Komeda, H., Osanai, H., Yanaoka, K., Okamoto, Y., Fujioka, T., Arai, S., Inohara, K., Koyasu, M., Kusumi, T., Takiguchi, S., Kawatani, M., Kumazaki, H., Hiratani, M., Tomoda, A., & Kosaka, H.
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 37875-37875
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Aripiprazole in the treatment of irritability in children and adolescents with autism spectrum disorder in Japan: A randomized, double-blind, placebo-controlled study.2016
Author(s)
Ichikawa H, Mikami K, Okada T, Yamashita Y, Ishizaki Y, Tomoda A, Ono H, Usuki C, Tadori Y.
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Journal Title
Child Psychiatry Hum Dev
Volume: 7(6)
Issue: 5
Pages: 841-851
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Ventral striatum dysfunction in children and adolescents with reactive attachment disorder: A functional MRI Study.2015
Author(s)
Takiguchi S, Fujisawa TX, Mizushima S, Saito DN, Okamoto Y, Shimada K, Koizumi M, Kumazaki H, Jung M, Kosaka H, Hiratani M, Ohshima Y, Teicher, MH, Tomoda A.
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Journal Title
British Journal of Psychiatry Open
Volume: 1
Issue: 2
Pages: 121-128
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] The effect of oxytocin on detection of altruistic person for children.2016
Author(s)
Koizumi M, Matsumura Y, Ishikawa S, Matsumoto H, Masuya Y, Okazaki R, Okamoto Y, Fujioka T, Takiguchi S, Tomoda A, Kosaka H
Organizer
The 22nd International Association for Child and Adolescent Psychiatry and Allied Professions (IACAPAP) World Congress and the 36th CACAP Conference
Place of Presentation
Calgary, Canada
Related Report
Int'l Joint Research
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[Presentation] The neural effects of intranasal oxytocin administration in reactive attachment disorder.2016
Author(s)
Takiguchi S, Fujisawa TX, Mizushima S, Saito DN, Shimada K, Okamoto Y, Nishikawa S, Takada S, Mizuno Y, Kosaka H, Tomoda A
Organizer
第58回日本小児神経学会学術総会
Place of Presentation
京王プラザホテル(東京都新宿区)
Related Report
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[Presentation] Low striatal activity during reward perception caused by childhood adversity.2015
Author(s)
Takiguchi S, Fujisawa TX, Mizushima S, Saito DN, Kumazaki H, Koizumi M, Shimada K, Okamoto Y, Jung M, Kosaka H, Tomoda A.
Organizer
第57回日本小児神経学会 English Session 4（口頭発表）
Place of Presentation
大阪市、帝国ホテル
Year and Date
2015-05-29
Related Report
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[Presentation] Reward sensitivity dysfunction in children and adolescents with reactive attachment disorder.2015
Author(s)
Takiguchi S, Fujisawa TX, Mizushima S, Saito DN, Okamoto Y, Shimada K, Kumazaki H, Koizumi M, Jung M, Kosaka H, Tomoda A
Organizer
The 13th Asian and Oceania Congress of Child Neurology (2015 AOCCN) （口頭発表）
Place of Presentation
Taipei City, Taiwan
Year and Date
2015-05-15
Related Report
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[Book] The Cultural Nature of Attachment: Contextualizing Relationships and Development,2018
Author(s)
Bennett A, Hopkins W, Feldman R, Gazzola V, Giedd J, Lamb M, Scheele D, Sheridan M, Suomi S, Tomoda A, Tottenham N
Total Pages
27
Publisher
MIT Press
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