| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Outline of Final Research Achievements |
In this study, we conducted an exploratory study of bioactive natural products effective for cancer and tuberculosis using established screening systems focusing on unique phenotypic changes of cells and pathogenic microbes in tumor and infected region. As a result, 14 bioactive natural products containing 7 novel compounds were discovered. In addition, we analyzed the action mechanism and binding protein of isolated bioactive natural products using the methods of molecular biology or chemical biology. Then, several molecules that were expected to be new drug targets, were successfully identified.
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