Neuronal mechanisms that regulate hyper-arousal in response to stress and anxiety
| Project/Area Number |
15H03122
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic / Social brain science
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| Research Institution | University of Tsukuba (2016-2017)
Kanazawa University (2015) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2017: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2016: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Keywords | 覚醒 / 情動 / 大脳辺縁系 / オレキシン / 不安 / 分界条床核 / 不眠 / ストレス / 睡眠 / 不眠障害 / 過覚醒 / 視床下部 |
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| Outline of Final Research Achievements |
We found that acute optogenetic excitation of GABA neurons in the BNST during non-rapid eye movement (NREM) sleep in mice resulted in immediate transition to a wakefulness state without the function of orexins. Prolonged excitation of GABABNST neurons by a chemogenetic method evoked a longer-lasting, sustained wakefulness state, which was abolished by pre-administration of a dual orexin receptor antagonist. We also found that when the orexin→NA→amygdala circuit was artificially activated, fear-related behavior increased in a similar but distinct from the training context. Increased activation of these circuits enhanced the fear response in otherwise neutral situation. Conditions that naturally activate orexin neurons, such as fasting, could result in an orexin-dependent shift to a ‘vigilance’ state and alter the selection of a behavioral response to avoid and handle environmental threats.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models2017
Author(s)
Irukayama-Tomobe Y, Ogawa Y, Tominaga H, Ishikawa Y, Hosokawa N, Ambai S, Kawabe Y, Uchida S, Nakajima R, Saitoh T, Kanda T, Vogt K, Sakurai T, Nagase H, Yanagisawa M.
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 114
Issue: 22
Pages: 5731-5736
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Serotonin neurons of the dorsal raphe mediate the anti-cataplectic action of orexin neurons by reducing the amygdala activity2017
Author(s)
Hasegawa, E., Maejima, T., Yoshida, T., Masseck O.A., Herlitze, S., Yoshioka, M., Sakurai, T., Mieda, M.
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 114
Issue: 17
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Serotonin neurons of the dorsal raphe mediate the anti-cataplectic action of orexin neurons by reducing the amygdala activity2017
Author(s)
Hasegawa, E., Maejima, T., Yoshida, T., Masseck O.A., Herlitze, S., Yoshioka, M., Sakurai, T., Mieda, M.
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 114
Related Report
Peer Reviewed
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[Journal Article] QRFP-deficient mice are hypophagic, lean, hypoactive and exhibit increased anxiety-like behavior2016
Author(s)
Okamoto K, Yamasaki M, Takao K, Soya S, Iwasaki M, Sasaki K, Magoori K, Sakakibara I, Miyakawa T, Mieda M, Watanabe M, Sakai J, Yanagisawa M, Sakurai T
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Journal Title
PLoS ONE
Volume: 11
Issue: 11
Pages: e0164716-e0164716
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Nighttime Administration of Nicotine Improves Hepatic Glucose Metabolism via the Hypothalamic Orexin System in Mice.2015
Author(s)
Tsuneki H, Nagata T, Fujita M, Kon K, Wu N, Takatsuki M, Yamaguchi K, Wada T, Nishijo H, Yanagisawa M, Sakurai T, Sasaoka T.
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Journal Title
Endocrinology
Volume: 157
Pages: 195-206
Related Report
Peer Reviewed
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[Journal Article] Messenger RNA expression profile of sleep-related genes in peripheral blood cells in patients with chronic kidney disease.2015
Author(s)
Kitajima S, Iwata Y, Furuichi K, Sagara A, Shinozaki Y, Toyama T, Sakai N, Shimizu M, Sakurai T, Kaneko S, Wada T.
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Journal Title
Clin Exp Nephrol
Volume: 20
Issue: 2
Pages: 218-25
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] The role of adult born neurons during sleep.2015
Author(s)
Sakaguchi, M., Kumar, D., Hayashi, M., Yu, L.M., McHugh, T.J., Sakurai, T.
Organizer
The 38th Annual Meeting of the Japan Neuroscience Society
Place of Presentation
神戸コンベンションセンター
Year and Date
2015-07-28
Related Report
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[Presentation] Cellular clocks in AVP neurons of the SCN are critical for interneuronal coupling regulating circadian behavior thythm.2015
Author(s)
Mieda, M., Ono, D., Hasegawa, E., Okamoto, H., Honma, K., Honma, S., Sakurai, T.
Organizer
The 38th Annual Meeting of the Japan Neuroscience Society
Place of Presentation
神戸コンベンションセンター
Year and Date
2015-07-28
Related Report
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