Neural mechanisms of interaction between the extended body and environment.

• Project/Area Number: 15H03126
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Basic / Social brain science
• Research Institution: Dokkyo Medical University (2018); National Rehabilitation Center for Persons with Disabilities (2015-2017)
• Principal Investigator: KANSAKU KENJI 獨協医科大学, 医学部, 教授 (60399318)
• Co-Investigator(Kenkyū-buntansha): 高野 弘二 国立障害者リハビリテーションセンター(研究所), 研究所 脳機能系障害研究部, 研究員 (00510588)
• Research Collaborator: KAWASE Toshihiro ; SATO Yuki ; OKAHARA Yoji ; HAYASHI Nana ; HALDER Sebastian
• Project Period (FY): 2015-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000); Fiscal Year 2018: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
• Keywords: 自己 / 身体 / 環境 / BMI / コミュニケーション

Outline of Final Research Achievements

In this study we first investigated the incorporation of prosthetic arms in amputees using the crossed hands illusion, in which successive somatosensory stimuli are delivered, one to each arm, at intervals of 300ms or less. The induced reversal illusion was greater with a prosthetic limb than without in amputees, which suggested that somatosensory signals were referred to the spatial location of the tips of the prosthetic arm. We then applied a robotic arm using myoelectric control in the rubber hand illusion. The sense of ownership and agency in able-bodied participants and amputees was extended to the robotic arm when the wrists of the real and robotic arms were flexed/extended synchronously, which suggested that incorporation of the prosthesis was induced. We also prepared a rubber tail and used the rubber tail to induce illusion in mice, like the rubber hand illusion. Our results suggested that our experimental setting allows us to investigate body ownership in mice.

Academic Significance and Societal Importance of the Research Achievements

切断者を対象とした一連の実験の結果は、義手や自身で操作できる運動補助装置に身体性が拡張していることを示唆するものであり、自分の身体の一部となる義手の開発などに向け、有用な知見となり得る。また、マウスの尾に対するラバーハンド錯覚と類似した錯覚は、これまでヒトやサルのみで報告されていた現象をはじめてマウスで報告したものであり、身体に関する脳内表現をニューロンレベルで明らかとするために貢献し得る。

Research Products

• [Int'l Joint Research] オックスフォード大学(英国)
• [Int'l Joint Research] テュービンゲン大学(ドイツ)
• [Int'l Joint Research] オスロ大学(ノルウェー)
• [Int'l Joint Research] オックスフォード大学(英国)
• [Journal Article] Long-term use of a neural prosthesis in progressive paralysis. (2018)
  • Author(s): Okahara, Y., Takano, K., Nagao, M., Kondo, K., Iwadate, Y., Birbaumer, N., Kansaku, K.
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 16787-16787
  • DOI: 10.1038/s41598-018-35211-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comparison of four control methods for a five-choice assistive technology (2018)
  • Author(s): Halder, S., Takano, T., Kansaku, K.
  • Journal Title: Frontiers in Human Neuroscience Volume: 12 Pages: 228-228
  • DOI: 10.3389/fnhum.2018.00228
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Body ownership and agency altered by an electromyographically-controlled robotic arm. (2018)
  • Author(s): Sato, Y., Kawase, T., Takano, K., Spence, C, Kansaku, K.
  • Journal Title: Royal Society Open Science, Volume: 5(5) Issue: 5 Pages: 172170-172170
  • DOI: 10.1098/rsos.172170
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Operation of a P300-based brain-computer interface in patients with Duchenne muscular dystrophy. (2018)
  • Author(s): Utsumi, K., Takano, K., Okahara, Y., Komori, T., Onodera, O., Kansaku, K.
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 1753-1753
  • DOI: 10.1038/s41598-018-20125-6
  • Peer Reviewed / Open Access
• [Journal Article] Incorporation of prosthetic limbs into the body representation of amputees: Evidence from the crossed hands temporal order illusion. (2017)
  • Author(s): Sato, Y., Kawase, T., Takano, K., Spence, C., Kansaku, K.
  • Journal Title: Progress in Brain Research Volume: 236 Pages: 225-241
  • DOI: 10.1016/bs.pbr.2017.08.003
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Affective stimuli for an auditory P300 brain-computer interface. (2017)
  • Author(s): Onishi, A., Takano, K., Kawase, T., Ora, H., Kansaku, K.
  • Journal Title: Frontiers in Neuroscience Volume: 11 Pages: 522-522
  • DOI: 10.3389/fnins.2017.00522
  • Peer Reviewed / Open Access
• [Journal Article] Operation of a P300-based brain-computer interface by patients with spinocerebellar ataxia. (2017)
  • Author(s): Okahara, Y., Takano, K., Komori, T., Nagao, M., Iwadate, Y., Kansaku, K.
  • Journal Title: Clinical Neurophysiology Practice Volume: 2 Pages: 147-153
  • DOI: 10.1016/j.cnp.2017.06.004
  • Peer Reviewed / Open Access
• [Journal Article] A hybrid BMI-based exoskeleton for paresis: EMG control for assisting arm movements. (2017)
  • Author(s): Kawase T, Sakurada T, Koike Y, Kansaku K.
  • Journal Title: Journal of Neural Engineering Volume: 14（1） Issue: 1 Pages: 016015-016015
  • DOI: 10.1088/1741-2552/aa525f
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The rubber tail illusion as evidence of body ownership in mice. (2016)
  • Author(s): Wada, M., Takano, K., Ora, H., Ide, M., Kansaku, K.
  • Journal Title: The Journal of Neuroscience Volume: 36 Issue: 43 Pages: 11133-11137
  • DOI: 10.1523/jneurosci.3006-15.2016
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Arm crossing updates brain functional connectivity of the left posterior parietal cortex. (2016)
  • Author(s): Ora H, Wada M, Salat D, Kansaku K.
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 28105-28105
  • DOI: 10.1038/srep28105
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] An evaluation of training with an auditory P300 brain-computer interface for the Japanese Hiragana syllabary. (2016)
  • Author(s): Halder S, Takano T, Ora H, Onishi A, Utsumi K, Kansaku K.
  • Journal Title: Frontiers in Neuroscience Volume: 10 Pages: 446-446
  • DOI: 10.3389/fnins.2016.00446
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] ブレイン-マシン・インターフェイス技術によるコミュニケーション支援 (2016)
  • Author(s): 神作憲司
  • Journal Title: ノーマライゼーション-障害者の福祉 Volume: 36 Pages: 16-19
• [Journal Article] Use of high-frequency visual stimuli above the critical flicker frequency in a SSVEP-based BMI. (2015)
  • Author(s): Sakurada, T., Kawase, T., Komatsu, T., Kansaku, K.
  • Journal Title: Clinical Neurophysiology Volume: 126 Issue: 10 Pages: 1972-1978
  • DOI: 10.1016/j.clinph.2014.12.010
  • Peer Reviewed
• [Presentation] Decoder construction for MEG signals in a subitizing task. (2019)
  • Author(s): Takano, K., Kansaku, K.
  • Organizer: The 96th Annual Meeting of the Physiological Society of Japan
  • Int'l Joint Research
• [Presentation] Body ownership and agency altered by a robotic arm controlled by electromyography of elbow muscles. (2019)
  • Author(s): Kawase, T., Kono, K., Cho, K., Kato, E., Kansaku, K.
  • Organizer: The 96th Annual Meeting of the Physiological Society of Japan
  • Int'l Joint Research
• [Presentation] Lower C-Fos expressions in the posterior parietal cortex during rubber tail task in Caps2 KO mice. (2019)
  • Author(s): Wada, M., Ide, M., Atsumi, T., Takano, K., Sano, Y., Shinoda, Y, Kansaku, K.
  • Organizer: The 96th Annual Meeting of the Physiological Society of Japan
  • Int'l Joint Research
• [Presentation] 高周波点滅視覚刺激を用いたSSVEP型-BMIアシストロボットの実装. (2018)
  • Author(s): 櫻田武、神作憲司.
  • Organizer: 第5回脳神経外科BMI懇話会
• [Presentation] Utility of peripheral visual field in the SSVEP-based brain-computer interface. (2018)
  • Author(s): Takano, K., Morita-Hayashi, N., Kansaku, K.
  • Organizer: The 48th Annual Meeting of the Society for Neuroscience
  • Int'l Joint Research
• [Presentation] EMG-controlled robotic arm intended to be incorporated into body representation. (2018)
  • Author(s): Kawase, T., Sato, Y., Kansaku, K.
  • Organizer: The 41st Annual Meeting of Japan Neuroscience Society
  • Int'l Joint Research
• [Presentation] Operation of a SSVEP-based BMI in a patient who progressed to the completely locked-in state. (2018)
  • Author(s): Okahara, Y., Takano, K., Nagao, M., Iwadate, Y., Kansaku, K.
  • Organizer: The 41st Annual Meeting of Japan Neuroscience Society
  • Int'l Joint Research
• [Presentation] 脳情報の解析と利用 (2018)
  • Author(s): 神作憲司
  • Organizer: 第48回千葉大学脳神経外科医会研究会
  • Invited
• [Presentation] 脳からの情報を利用する：神経生理学に何が出来るか？ (2018)
  • Author(s): 神作憲司
  • Organizer: 北海道大学大学院医学研究院・第129回ニューロサイエンス談話会
  • Invited
• [Presentation] 神経難病領域における脳情報利用の試み (2018)
  • Author(s): 神作憲司
  • Organizer: 日本難病看護学会・企画セミナー/箱根病院・箱根で学ぶ神経難病看護シリーズ
  • Invited
• [Presentation] C-Fos expressions in the cerebral cortex during rubber tail task in mice. (2018)
  • Author(s): Wada, M., Ide, M., Atsumi, T., Takano, K., Ora, H., Kansaku, K.
  • Organizer: The 95th Annual Meeting of the Physiological Society of Japan.
• [Presentation] 神経難病へのブレイン-マシン・インターフェイス（BMI）の応用. (2017)
  • Author(s): 神作憲司.
  • Organizer: 第7回神経難病リハビリテーション研究会.
  • Invited
• [Presentation] ブレイン－マシン・インタフェースによるコミュニケーションと運動の補助. (2017)
  • Author(s): 神作憲司.
  • Organizer: 第109回 ロボット工学セミナー・臨床応用から理解するリハビリテーション・ロボティクス
  • Invited
• [Presentation] 上肢アシストスーツに対する脳波筋電ハイブリッド制御 (2017)
  • Author(s): 川瀬利弘、小池康晴、神作憲司.
  • Organizer: LIFE2017
• [Presentation] Effect of vision of arm posture on a crossed hands illusion task in an amputee. (2017)
  • Author(s): Sato, Y., Kawase, T., Takano, K., Kansaku, K.
  • Organizer: The 47th Annual Meeting of the Society for Neuroscience.
  • Int'l Joint Research
• [Presentation] Effect of synchronous movement of an EMG controlled robotic arm on robot hand illusion in amputees. (2017)
  • Author(s): Sato, Y., Kawase, T., Takano, K., Kansaku, K.
  • Organizer: The 40th Annual Meeting of Japan Neuroscience Society
  • Int'l Joint Research
• [Presentation] A BMI-based robotic exoskeleton for neurorehabilitation and daily actions: hybrid control based on EMG and SSVEP for elbow and wrist. (2017)
  • Author(s): Kawase, T., Koike, Y., Kansaku, K.
  • Organizer: The 40th Annual Meeting of Japan Neuroscience Society
  • Int'l Joint Research
• [Presentation] P300-based brain-machine interface applied to patients with Duchenne muscular dystrophy. (2017)
  • Author(s): Utsumi, K., Okahara, Y., Takano, K., Komori, T., Onodera, O., Kansaku, K.
  • Organizer: Real-time functional imaging and neurofeedback conference 2017.
  • Int'l Joint Research
• [Presentation] Effect of oxytocin on a rubber tail task in CAPS2 KO mice: an initial study (2017)
  • Author(s): Wada, M., Atsumi, T., Ide, M., Sano, Y., Shinoda, Y., Furuichi, T., Kansaku, K.
  • Organizer: The 77th Annual Meeting of the Japanese Society for Animal Psychology.
• [Presentation] 脳波によるBMI技術：社会への実装に向けて (2017)
  • Author(s): 神作憲司
  • Organizer: 第19回日本ヒト脳機能マッピング学会・シンポジウム
  • Place of Presentation: 京都, 京都大学百周年時計台記念館
• [Presentation] EEG evaluation of relative change of subjective sleepiness. (2017)
  • Author(s): Utsumi, K., Takano, K., Onodera, O., Kansaku, K.
  • Organizer: The 94th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: 浜松, アクトシティ浜松
  • Int'l Joint Research
• [Presentation] Comparison between response in real tail grasping and rubber tail illusion in mice. (2017)
  • Author(s): Wada, M., Ide, M., Takano, K., Ora, H., Kansaku, K.
  • Organizer: The 94th Annual Meeting of the Physiological Society of Japan.
  • Place of Presentation: 浜松, アクトシティ浜松
  • Int'l Joint Research
• [Presentation] C-Fos and Arc expression during a rubber tail task in mice: an initial study. (2016)
  • Author(s): Wada, M., Ide, M., Ora, H., Kansaku, K.
  • Organizer: The 93rd Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: 札幌, コンベンションセンター
  • Year and Date: 2016-03-24
• [Presentation] A rubber tail task in CAPS2 KO mice: second report. (2016)
  • Author(s): Wada, M. Ide, M., Atsumi, T., Yagishita, K., Katakai, M., Shinoda, Y., Furuichi, T., Kansaku, K.
  • Organizer: The 76th Annual Meeting of the Japanese Society for Animal Psychology.
  • Place of Presentation: 札幌, 北海道大学 学術交流会館
• [Presentation] Speech comprehension in patients with persistent vegetative state: a neuroimaging approach. (2016)
  • Author(s): Okahara, Y., Utsumi, K., Takano, K., Odaka, K., Uchino, Y., Kansaku, K.
  • Organizer: The 46th Annual Meeting of the Society for Neuroscience.
  • Place of Presentation: San Diego Convention Center, San Diego, USA.
  • Int'l Joint Research
• [Presentation] A rubber tail task in Ca2+-dependent activator protein for secretion (CAPS) 2 knockout mice. (2016)
  • Author(s): Wada, M., Ide, M., Atsumi, T., Yagishita, K., Katakai, M., Shinoda, Y., Furuichi, T., Kansaku, K.
  • Organizer: The 46th Annual Meeting of the Society for Neuroscience.
  • Place of Presentation: San Diego Convention Center, San Diego, USA.
  • Int'l Joint Research
• [Presentation] 無反応覚醒症候群における感覚性言語中枢の神経画像評価. (2016)
  • Author(s): 岡原陽二、宇津見宏太、高野弘二、内野福生、岩立康男、神作憲司.
  • Organizer: 第75回 日本脳神経外科学会総会
  • Place of Presentation: 福岡, 福岡国際会議場
• [Presentation] A crossed hands illusion task in an amputee with a prosthesis. (2016)
  • Author(s): Sato, Y., Ora, H., Takano, K., Kansaku, K.
  • Organizer: The 39th Annual Meeting of Japan Neuroscience Society
  • Place of Presentation: 横浜, パシフィコ横浜
  • Int'l Joint Research
• [Presentation] A BMI-based robotic exoskeleton for neurorehabilitation and daily actions: effects of hybrid BMI-based assistance on muscle activities in a stroke patient. (2016)
  • Author(s): Kawase, T., Koike, Y., Kansaku, K.
  • Organizer: The 39th Annual Meeting of Japan Neuroscience Society
  • Place of Presentation: 横浜, パシフィコ横浜
  • Int'l Joint Research
• [Presentation] Affective sounds applied to auditory P300 brain-machine interface. (2016)
  • Author(s): Onishi, A., Ora, H., Kansaku, K.
  • Organizer: The 39th Annual Meeting of Japan Neuroscience Society
  • Place of Presentation: 横浜, パシフィコ横浜
  • Int'l Joint Research
• [Presentation] Initial evaluation of an auditory P300 brain-computer interface for the Japanese Hiragana syllabary. (2016)
  • Author(s): Halder, S., Takano, K., Ora, H., Onishi, A., Utsumi, K., Kansaku, K.
  • Organizer: International Brain-Computer Interface (BCI) Meeting 2016
  • Place of Presentation: Asilomar Conference Center, Pacific Grove, USA.
  • Int'l Joint Research
• [Presentation] A longitudinal evaluation of SSVEP-BMI in patients with ALS. (2015)
  • Author(s): Takano. K., Komatsu. T., Nagao. M., Kondo. K., Kansaku. K.
  • Organizer: The 45th Annual Meeting of Society for Neuroscience
  • Place of Presentation: 米国シカゴ, マコーミックプレイス
  • Year and Date: 2015-10-21
  • Int'l Joint Research
• [Presentation] Neurofeedback training improves decoding accuracy in MEG/SSVEF. (2015)
  • Author(s): Ora, H., Kansaku, K.
  • Organizer: The 45th Annual Meeting of Society for Neuroscience
  • Place of Presentation: 米国シカゴ, マコーミックプレイス
  • Year and Date: 2015-10-21
  • Int'l Joint Research
• [Presentation] A rubber hand experiment using an EMG controlled robotic arm in amputee participants. (2015)
  • Author(s): Sato, Y., Kawase, T., Kansaku. K.
  • Organizer: The 45th Annual Meeting of Society for Neuroscience
  • Place of Presentation: 米国シカゴ, マコーミックプレイス
  • Year and Date: 2015-10-19
  • Int'l Joint Research
• [Presentation] A rubber tail task in CAPS2 KO mice: an initial study. (2015)
  • Author(s): Wada, M. Ide, M., Yagishita, K., Katakai, M., Shinoda, Y., Furuichi, T., Kansaku,
  • Organizer: The 75th Annual Meeting of the Japanese Society for Animal Psychology
  • Place of Presentation: 東京, 日本女子大学
  • Year and Date: 2015-09-11
• [Presentation] A BMI-based robotic exoskeleton for neurorehabilitation and daily actions: use of a hybrid control method based on EMG and SSVEP in a stroke patient. (2015)
  • Author(s): Kawase, T., Koike. Y., Kansaku. K.
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸, 神戸国際会議場
  • Year and Date: 2015-07-29