| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Outline of Final Research Achievements |
In order to clarify the aligned collagen fibrils and sugar modification of collagen as well as the formation factors of oriented extracellular matrix of collagen fibrils, gradient materials of collagen and hydroxyapatite by electrochemical reaction and the glycosylated collagen using thiolate reaction were succeeded. It was revealed that glycosylation increased the initial adhesion number of fibroblasts. We also established a technique to visualize collagen secretion from cells and clarified that in situ collagen integrity process and in situ measurement of secretion status. By utilizing these technologies, it can be expected to be useful for future scaffolds for regenerative medicine and devices for drug discovery development.
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