Research on fish scale collagen material technology by field fusion
| Project/Area Number |
15H03526
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nanomaterials chemistry
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
Ikoma Toshiyuki 東京工業大学, 物質理工学院, 准教授 (20370306)
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| Co-Investigator(Kenkyū-buntansha) |
田中 利明 東京工業大学, 生命理工学院, 助教 (40263446)
杉山 友明 東京工業大学, 物質理工学院, 助教 (90744178)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | 生体外マトリックス / 細胞分泌 / コラーゲン / 遺伝子導入 / 化学修飾 / 分泌経路 / ナノ材料 / 配向構造 / ナノ機能材料 / 階層ナノ構造 |
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| Outline of Final Research Achievements |
In order to clarify the aligned collagen fibrils and sugar modification of collagen as well as the formation factors of oriented extracellular matrix of collagen fibrils, gradient materials of collagen and hydroxyapatite by electrochemical reaction and the glycosylated collagen using thiolate reaction were succeeded. It was revealed that glycosylation increased the initial adhesion number of fibroblasts. We also established a technique to visualize collagen secretion from cells and clarified that in situ collagen integrity process and in situ measurement of secretion status. By utilizing these technologies, it can be expected to be useful for future scaffolds for regenerative medicine and devices for drug discovery development.
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Report
(4 results)
Research Products
(30 results)
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[Book] ナノバイオとナノメディシン2015
Author(s)
生駒俊之, 田中順三, 伊藤博, 芹澤武, 早乙女進一, 花方信孝, 吉岡朋彦, 沢田敏樹, 多賀谷基博
Total Pages
320
Publisher
コロナ社
Related Report
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