Development of next-generation wireless-electroless oscillator biosensors for diagnosis and drug development
| Project/Area Number |
15H03587
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General applied physics
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| Research Institution | Osaka University |
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Principal Investigator |
Ogi Hirotsugu 大阪大学, 工学研究科, 教授 (90252626)
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| Co-Investigator(Kenkyū-buntansha) |
南野 哲男 香川大学, 医学部, 教授 (30379234)
後藤 祐児 大阪大学, たんぱく質研究所, 教授 (40153770)
中村 暢伴 大阪大学, 基礎工学研究科, 助教 (50452404)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2015: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | QCM / バイオセンサー / 蛋白質相互作用 / 無線 / QCMバイオセンサー / MEMSプロセス / アミロイド線維 / 計測工学 / マイクロ・ナノデバイス / 核酸 / 脳神経疾患 / アミロイドβ / 超音波 |
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| Outline of Final Research Achievements |
We have developed MEMS quartz-crystal-microbalance biosensors and succeeded in improving the stability and sensitivity. The high-frequency biosensors allowed us to detect target proteins even in a solution with impurity proteins whose concentrations were much higher than that of target protein. The viscoelasticity was successfully monitored during the structural transduction of Amyloid beta peptide using higher vibrational modes. Furthermore, combination of the wireless-electrodeless QCM in the total internal reflection fluorescence microscopy revealed novel properties of fibrillation of the papeitdes.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] RNA Aptamer Binds Heparin-Binding Epidermal Growth Factor-Like Growth Factor with High Affinity and Specificity and Neutralizes Its Activity.2017
Author(s)
Masaki Yamato, Tetsuo Minamino, yamato masaki, Takashi Matsuzaki, Ryo Araki, Shota Tsuchida, Keiji Okuda, Hai Ying Fu, Shoji Sanada, Hiroshi Asanuma, Yoshihiro Asano, Masanori Asakura, Hiroomi Torii, Kentaro Noi, Hirotsugu Ogi, Ryo Iwamoto, Eisuke Mekada, Seiji Takashima, Yasushi Sakata, Masafumi Kitakaze
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Journal Title
Int. J. Gerontol.
Volume: 11
Issue: 3
Pages: 191-196
DOI
Related Report
Peer Reviewed
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