| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
In this research, we developed novel molecular technology mainly aimed at application to cells using DNA nanotechnology. To control the function of the cells, we construct a series of molecular systems by functionalizing nanostructures and nanospaces by precisely designed DNA. We created controllable dynamic nanostructures having opening and closing mechanism in response to light and specific molecules, and investigated the functions using high speed AFM. We created assembly system of DNA nanostructures on lipid membrane. A DNA nanostructure having a needle-like structure which can penetrate the lipid membrane was constructed, and target molecules were incorporated into the liposome. In addition, a novel delivery system to cells was constructed using controllable DNA nanostructures. Through these studies, we will develop novel molecular technologies for control of cell functions using controllable DNA structures and assemblies.
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