Evaluation of Liver flow dynamics for organ preservation, recovery and assessment to develop future medical devices
| Project/Area Number |
15H03922
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fluid engineering
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| Research Institution | Tokyo Metropolitan University |
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Principal Investigator |
obara Hiromichi 首都大学東京, 理工学研究科, 准教授 (80305424)
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| Co-Investigator(Kenkyū-buntansha) |
松野 直徒 旭川医科大学, 医学部, 特任教授 (00231598)
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| Co-Investigator(Renkei-kenkyūsha) |
Enosawa Shin 国立成育医療研究センター, 研究所, 室長 (40232962)
HIRANO Toshihiko 東京薬科大学, 薬学部, 教授 (90173252)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Keywords | 臓器移植 / 臓器工学 / 機械灌流 / 機能評価 / 灌流保存 / 医用工学 / 流体工学 / 臓器再生 / 移植医療 / 医療機器 / 再生医療 |
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| Outline of Final Research Achievements |
Technology for an organ preservation, recovery and assessment is very important to develop future medical devices to enhance organ quality for transplantation. The use of organ donated after cardiac death (DCD) treated with the future medical device would greatly contribute to expansion of the donor organ pool. Machine perfusion (MP) is a promising technology to preserve the organ function and improve the organ quality of the DCD. Furthermore, organ assessment with the MP is effective to treat DCD organ. Although several perfusion technologies under various conditions have been suggested, optimum condition and adequate technology are still debated. In particularly, there are few studies of the ex vivo liver flow dynamics under several MP condition. In this study, we evaluated the the ex vivo liver flow dynamics using micro and macro experimental approaches and numerical analysis.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Optimum perfusate volume of purified subnormothermic machine perfusion for porcine liver donated after cardiac deat2018
Author(s)
Hiromichi Obara, Noriyuki Morito, Naoto Matsuno, Ryo Yoshikawa, Mikako Gouchi, Masahide Otani, Tatsuya Shonak, Hiroyuki Takahashi, Shin Enosawa, Toshihiko Hirano, Hiroyuk iFurukawa
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Journal Title
Transplantation Proceedings
Volume: 印刷中
Issue: 9
Pages: 2830-2833
DOI
Related Report
Peer Reviewed
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[Journal Article] The application of perfusate with human-derived oxygen carrier solution under subnormothermic machine perfusion for donation after cardiac death (DCD) liver grafts in pigs2017
Author(s)
Tatsuya Shonaka, Naoto Matsuno, Hiromichi Obara, Ryo Yoshikawa, Yuji Nishikawa,Mikako Goucha, Masahide Otana, Hiroyuki Takahashi, Hiroshi Azuma, Hiromi Sakai, Hiroyuki Furukawa
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Journal Title
Transpl Proc
Volume: Transpl Proc
Issue: 9
Pages: 2821-2825
DOI
Related Report
Peer Reviewed
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[Journal Article] Multipronged strategy of purposeful use of organs from non-heart beating donors2015
Author(s)
松野 直徒, 古郡 茉利子, 渡邊 賢二, 庄中 達也, 孟 玲童, 今井 浩二, 暮地本 宙己, 渡部 剛, 田崎 嘉一, 西川 祐司, 小原 弘道, 絵野沢 伸, 古川 博之
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Journal Title
Organ Biology
Volume: 22
Issue: 2
Pages: 121-127
DOI
NAID
ISSN
1340-5152, 2188-0204
Related Report
Open Access
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