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Measurement and analysis of temperature characteristics and thermal physics of blood cell, blood flow and blood vessel using microfluidic platform

Research Project

Project/Area Number 15H03931
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Thermal engineering
Research InstitutionKyoto University

Principal Investigator

Kazuya Tatsumi  京都大学, 工学研究科, 准教授 (90372854)

Co-Investigator(Renkei-kenkyūsha) NAKABE Kazuyoshi  京都大学, 大学院工学研究科, 教授 (80164268)
Research Collaborator HIRAKATA Hideo  京都市立病院, 研究員 (70271509)
SUGITA Naoko  京都大学, 大学院医学研究科, 助教 (20750532)
KURIYAMA Reiko  京都大学, 大学院工学研究科, 助教 (70781780)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Keywords血栓 / 熱物性 / マイクロ流体工学 / 反応定数 / 静脈血栓 / フィブリン / トロンビン / 凝固時間 / 血球 / マイクロ流路 / 温度特性 / 血流内の拡散係数 / 流れでのフィブリン網の計測と評価 / 生体熱物性 / 血液対流 / 物質輸送 / 温度 / 物質拡散 / フィブリン塊 / 血栓形成 / 血流 / 蛍光観察 / フィブリン網 / 流れ
Outline of Final Research Achievements

Point of origin and the formation process of the thrombus, thrombus formation time, and the reaction constant of fibrin reaction was measured using microfluidic device, micro-capillary, and cuvette for human blood to evaluate the effects of flow and temperature on vinous thrombus formation. We showed that in the case of low flow rate observed in vein, the fibrin fibers grow from the platelets attached to the channel wall from which the thrombus starts to form. The pattern of the fibrin fibers showed a correlation with the mass concentration pattern diffused and convected from the platelet, the results from which we showed that the flow and concentration of the coagulation factors affects the thrombus formation. Further, the relationship between the temperature and the thrombus formation time and the fibrin concentration showed that the thrombus formation time increases as the temperature increase or decrease from the range of 37-40C due to the decrease of the reaction coefficient.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (19 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (16 results) (of which Int'l Joint Research: 6 results,  Invited: 3 results)

  • [Int'l Joint Research] IIT Kanpur(インド)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Liquid Temperature Measurement Method in Microchannels by Using Fluorescence Polarization2017

    • Author(s)
      (1)K. Tatsumi, C-H Hsu, A. Suzuki, K. Nakabe
    • Journal Title

      Heat and Mass Transfer

      Volume: 1 Issue: 8 Pages: 1-10

    • DOI

      10.1007/s00231-017-2104-6

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temperature measurement in microchannel liquid flow by measuring fluorescence polarization2017

    • Author(s)
      鈴木淳史,巽和也,堀井悟史,栗山怜子,中部主敬
    • Journal Title

      Transactions of the JSME (in Japanese)

      Volume: 83 Issue: 853 Pages: 17-00200-17-00200

    • DOI

      10.1299/transjsme.17-00200

    • NAID

      130006099959

    • ISSN
      2187-9761
    • Related Report
      2017 Annual Research Report
  • [Presentation] Thermal Characteristics Measurement of Fibrin Reaction and Clot Formation in Venous Thrombus Using Microchannel Flow2018

    • Author(s)
      K. Tatsumi, Y. Yamamoto, A. Yanamoto, H. Hirakata, N. Sugita, K. Inoue, R. Kuriyama, K. Nakabe
    • Organizer
      16th International Heat Transfer Conference (IHTC-16)
    • Related Report
      2017 Annual Research Report
  • [Presentation] マイクロ流路強制対流輸送:粘弾性流体流れによる混合・伝熱促進2018

    • Author(s)
      巽和也
    • Organizer
      日本冷凍空調学会 さろんセミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Thermal Properties of Fibrin Clot Formation in Venous Thrombus2017

    • Author(s)
      K. Tatsumi, Y. Yamamoto, Yanamoto, N. Sugita, K. Inoue, K. Nakabe, H. Hirakata, N. Sugita and K. Inoue
    • Organizer
      9th World Conference on Experimental Heat Transfer, Fluid Mechanics and Thermodynamics
    • Place of Presentation
      Iguassu
    • Year and Date
      2017-06-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fluid Viscosity Measurement in Microchannels Using Fluorescence Polarization Imaging2017

    • Author(s)
      R. Kuriyama, T. Nakagawa, K. Tatsumi, K. Nakabe
    • Organizer
      9th JSME-KSME Thermal and Fluids Engineering Conference
    • Related Report
      2017 Annual Research Report
  • [Presentation] Microfluidic convection: convection and alignment control of particles in micro-channel flows using dielectric force2017

    • Author(s)
      K. Tatsumi
    • Organizer
      Seminar on Innovative Technologies in heat transfer, fluid mechanics and thermodynamics
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] The Blood Components Strongly Affect Thrombus Structure Formed in a Novel Microfluidic Device2017

    • Author(s)
      N. Sugita, H. Hirakata, K. Inoue, K. Koike, K. Tatsumi, S. Ii, H. Niioka, S. Wada
    • Organizer
      International Society on Thrombosis and Haemostasis 2017 Congress
    • Related Report
      2017 Annual Research Report
  • [Presentation] Thermal Characteristics of Fibrin Clot Formation in Venous Thrombus2017

    • Author(s)
      K. Tatsumi, Y. Yamamoto, A. Yanamoto, R. Kuriyama, K. Nakabe, H. Hirakata, N. Sugita, K. Inoue
    • Organizer
      9th World Conference on Experimental Heat Transfer, Fluid Mechanics and Thermodynamics
    • Related Report
      2017 Annual Research Report
  • [Presentation] 蛍光偏光法によるマイクロ流路内の2次元粘度分布計測2017

    • Author(s)
      中川友貴,栗山怜子,巽和也,中部主敬
    • Organizer
      第54回日本伝熱シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] マイクロ流路における熱物質輸送と粘弾性流体流れ2017

    • Author(s)
      巽和也
    • Organizer
      第10回希薄溶液の流動学講演
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 静脈血栓機構解明に向けたフィブリン塊形成の温度特性評価2017

    • Author(s)
      山本裕亮,柳本篤則,栗山怜子,巽和也,中部主敬
    • Organizer
      第54回日本伝熱シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Visualization of Venous Thrombus Initial Formation Using Microchannel Flow2016

    • Author(s)
      H. Shirouzu, Y. Yamamoto, S. Noguchi, K. Tatsumi, H. Hirakata, N. Sugita, K. Inoue, R. Kuriyama and K. Nakabe
    • Organizer
      International Symposium on Micro-Nano Science and Technology 2016
    • Place of Presentation
      Tokyo
    • Year and Date
      2016-12-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Measurement of Venous Thrombosis Formation and Mass Transfer Effects in the Initial Stage Using Microchannel Flow2016

    • Author(s)
      Y. Yamamoto, K. Tatsumi, H. Shirouzu, H. Hirakata, N. Sugita, K. Inoue and K. Nakabe
    • Organizer
      20th International Conference on Miniaturized Systems for Chemistry and Life Sciences
    • Place of Presentation
      Dublin
    • Year and Date
      2016-10-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 静脈血栓形成と物質拡散の関係解明に向けたマイクロ流路内可視化計測2016

    • Author(s)
      山本裕亮,白水仁,巽和也,平方秀男,杉田尚子,井上京,中部主敬
    • Organizer
      日本流体力学会 年会2016
    • Place of Presentation
      Nagoya
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Thrombus structure change under various shear rate, using a novel microfluidic device2016

    • Author(s)
      Hirakata H, Sugita N, Inoue K, Tatsumi K, Ii S, Wada S, Koike K and Murai T
    • Organizer
      62nd Annual SSC Meeting of the ISTH
    • Place of Presentation
      Montpellier
    • Year and Date
      2016-05-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Thermo-Physics of Thrombus Formation Measured by Using Micro-fluidic Platform2015

    • Author(s)
      8.K. Tatsumi, Y. Yamamoto, H. Shirouzu, H. Hirakata, N. Sugita, K. Inoue and K. Nakabe
    • Organizer
      15th Kyoto - Seoul National - Tsinghua University Thermal Engineering Conference
    • Place of Presentation
      Kyoto
    • Year and Date
      2015-11-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] Novel Microfluidic Device Development for Venous Thrombus Understanding2015

    • Author(s)
      N. Sugita, H. Hirakata, K. Inoue, K. Tatsumi and T. Murai
    • Organizer
      International Society on Thrombosis and Haemostasis, Congress
    • Place of Presentation
      Toronto
    • Year and Date
      2015-06-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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