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Development of numerical prediction method for indoor air quality distribution and inhalation exposure concentration

Research Project

Project/Area Number 15H04086
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Architectural environment/Equipment
Research InstitutionKyushu University

Principal Investigator

Ito Kazuhide  九州大学, 総合理工学研究院, 教授 (20329220)

Co-Investigator(Kenkyū-buntansha) Lim Eunsu  東洋大学, 理工学部, 准教授 (50614624)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2016: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2015: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywords数値人体モデル / 数値気道モデル / 経気道暴露 / 計算流体力学 / 室内空気環境 / 生理的薬物動態モデル / 室内環境 / 経気道曝露 / 可視化粒子画像流速計測法 / 対流熱伝達率
Outline of Final Research Achievements

The importance of indoor air quality (IAQ) has been increasing as people spend more time indoors. Especially, inhaled air concentration of resident has direct impact on health. Against this background, this study aimed to develop a comprehensive numerical human body model (Computer Simulated Person: CSP), that would integrate respiratory tract models for indoor environmental quality assessment, and to use the CSP to develop an integrated numerical simulation procedure for airflow, temperature and contaminant transport by computational fluid dynamics (CFD).
The significant outcomes of this study included the development of a CSP that reproduced both human body geometry and the respiratory tract from nasal and oral cavity to bronchial tubes in detail, the numerical simulation method to calculate the non-uniform distributions of indoor contaminants, and a method of evaluating inhalation exposure risk for a CSP with a respiratory tract model.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (39 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (2 results) Journal Article (14 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 14 results,  Acknowledgement Compliant: 8 results,  Open Access: 3 results) Presentation (20 results) (of which Int'l Joint Research: 15 results,  Invited: 1 results) Remarks (3 results)

  • [Int'l Joint Research] CDPH(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] RMIT(オーストラリア)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Flow visualization through particle image velocimetry in realistic model of rhesus monkey’s upper airway2018

    • Author(s)
      Kim Ji-Woong、Phuong Nguyen Lu、Aramaki Shin-ichiro、Ito Kazuhide
    • Journal Title

      Respiratory Physiology and Neurobiology

      Volume: 251 Pages: 16-27

    • DOI

      10.1016/j.resp.2018.02.007

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Integrated analysis of numerical weather prediction and computational fluid dynamics for estimating cross-ventilation effects on inhaled air quality inside a factory2017

    • Author(s)
      Murga Alicia、Sano Yusuke、Kawamoto Yoichi、Ito Kazuhide
    • Journal Title

      Atmospheric Environment

      Volume: 167 Pages: 11-22

    • DOI

      10.1016/j.atmosenv.2017.08.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Numerical Prediction of Tissue Dosimetry in Respiratory Tract using Computer Simulated Person integrated with physiologically based pharmacokinetic (PBPK)-computational fluid dynamics (CFD) Hybrid Analysis2017

    • Author(s)
      Sung-Jun Yoo and Kazuhide Ito
    • Journal Title

      Indoor and Built Environment,

      Volume: in Press Issue: 7 Pages: 877-889

    • DOI

      10.1177/1420326x17694475

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Returning and net escape probabilities of contaminant at a local point in indoor environment2017

    • Author(s)
      Chung Juyeon、Lim Eunsu、Sandberg Mats、Ito Kazuhide
    • Journal Title

      Building ans Environment

      Volume: 125 Pages: 67-76

    • DOI

      10.1016/j.buildenv.2017.08.028

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Prediction of convective heat transfer coefficients for the upper respiratory tracts of rat, dog, monkey, and humans2017

    • Author(s)
      Kazuhide Ito, Koki Mitsumune, Kazuki Kuga, Nguyen Lu Phuong, Kenji Tani, Kiao Inthavong
    • Journal Title

      Indoor and Built Environment

      Volume: (will be fixed) Issue: 6 Pages: 828-840

    • DOI

      10.1177/1420326x16662111

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Multi-stage downscaling procedure to analyze the impact of exposure concentration in a factory on a specific worker through CFD2017

    • Author(s)
      Alicia Murga, Sung-Jun Yoo and Kazuhide Ito
    • Journal Title

      Indoor and Built Environment

      Volume: (will be fixed soon) Issue: 4 Pages: 486-498

    • DOI

      10.1177/1420326x16677331

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A Device-independent Evaluation of Carbonyl Emissions from Heated Electronic Cigarette Solvents2017

    • Author(s)
      Ping Wang, Wenhao Chen, Jiawen Liao, Toshiki Matsuo, Kazuhide Ito, Jeff Fowles, Dennis Shusterman, Mark Mendell, Kazukiyo Kumagai
    • Journal Title

      PLOS ONE

      Volume: 12(1) Issue: 1 Pages: e0169811-e0169811

    • DOI

      10.1371/journal.pone.0169811

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Editorial, In silico human model for fluid-initiated indoor environmental design2017

    • Author(s)
      Kazuhide Ito
    • Journal Title

      Indoor and Built Environment

      Volume: 26(3) Issue: 3 Pages: 295-297

    • DOI

      10.1177/1420326x17697290

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] First- and second-hand smoke exposure assessment from e-cigarettes using integrated numerical analysis of CFD and a computer-simulated person with a respiratory tract model2017

    • Author(s)
      Kazuki Kuga, Kazuhide Ito, Sung-Jun Yoo, Wenhao Chen, Ping Wang, Jiawen Liao, Jeff Fowles, Dennis Shusterman, Kazukiyo Kumagai
    • Journal Title

      Indoor and Built Environment

      Volume: (will be fixed soon) Issue: 7 Pages: 898-916

    • DOI

      10.1177/1420326x17694476

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Prediction of convective heat transfer coefficient of human upper and lower airway surfaces in steady and unsteady breathing conditions2016

    • Author(s)
      Nguyen Lu Phuong, Masato Yamashita, Sung-Jun Yoo, Kazuhide Ito
    • Journal Title

      Building and Environment

      Volume: 100 Pages: 172-185

    • DOI

      10.1016/j.buildenv.2016.02.020

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Toward the development of an <i>in silico</i> human model for indoor environmental design2016

    • Author(s)
      Kazuhide Ito
    • Journal Title

      Proceedings of the Japan Academy, Series B

      Volume: 92 Issue: 7 Pages: 185-203

    • DOI

      10.2183/pjab.92.185

    • NAID

      130005253190

    • ISSN
      0386-2208, 1349-2896
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] アクリル製人体気道モデルを用いた気道内流れ場のPIV計測2015

    • Author(s)
      平瀬公太,山下真登,荒巻森一朗,伊藤一秀
    • Journal Title

      日本建築学会環境系論文集

      Volume: Vol.80,No.715 Pages: 751-758

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 完全統合型数値人体モデルの概要と経気道暴露濃度解析 気道モデルを統合した数値人体モデルの開発 第2報2015

    • Author(s)
      Sung-Jun Yoo,伊藤一秀
    • Journal Title

      日本建築学会環境系論文集

      Volume: Vol.80,No.716 Pages: 935-943

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Investigation of Flow Pattern in a Realistic Replica Model of Human Respiratory Tract using PIV2015

    • Author(s)
      Nguyen Lu Phuong and Kazuhide Ito
    • Journal Title

      Building and Environment

      Volume: 94 Issue: 1 Pages: 504-515

    • DOI

      10.15377/2409-9821.2015.02.01.4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Comparative computational modeling of airflow and regional deposition of inhaled particles in respiratory tract of human and monkey2018

    • Author(s)
      Nguyen Lu Phuong and Kazuhide Ito
    • Organizer
      COBEE 2018, Melbourne, Australia, pp453-456
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Quantitative risk assessment of transient inhalation exposure using PBPK-CFD hybrid model with computer simulated person2018

    • Author(s)
      Sung-Jun Yoo and Kazuhide Ito
    • Organizer
      COBEE 2018, Melbourne, Australia, pp417-419
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Virtual Bronchiole Model Based on the Numerical Respiratory Tract Model for Comprehensive Exposure Assessment to E-Cigarettes2017

    • Author(s)
      Kazuki Kuga, Sung-Jun Yoo, Kazuhide Ito, Wenhao Chen, Ping Wang, Jeff Fowles, Dennis Shusterman, Kazukiyo Kumagai
    • Organizer
      Healthy Buildings 2017 Asia, Taiwan, pp122-125
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Integration of numerical weather prediction and computational fluid dynamics to analyze indoor air quality: Part 1, prediction of wind pressure coefficient distributions2017

    • Author(s)
      Yusuke Sano, Alicia Murga, Yoichi Kawamoto, Kazuhide Ito
    • Organizer
      Healthy Buildings 2017 Asia, Taiwan, pp 227-231
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Integration of numerical weather prediction and computational fluid dynamics to analyze indoor air quality: Part 2, prediction of contaminant concentration and inhalation exposure in a factory2017

    • Author(s)
      Alicia Murga, Yusuke Sano, Yoichi Kawamoto, Kazuhide Ito
    • Organizer
      Healthy Buildings 2017 Asia, Taiwan, pp 62-66
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ventilation effectiveness in mammalian upper airways - computational fluid dynamics analysis of in silico airway models for rats, dogs, monkeys, and humans2017

    • Author(s)
      Nguyen Lu Phuong and Kazuhide Ito
    • Organizer
      Healthy Buildings 2017 Asia, Taiwan, pp 487-490
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Transient analysis of inhalation exposure by using computer simulated person integrated with PBPK-CFD hybrid model2017

    • Author(s)
      Sung-Jun Yoo and Kazuhide Ito
    • Organizer
      Healthy Buildings 2017 Asia, Taiwan, pp 135-138
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Computational modeling of airflows and gas-phase contaminant dispersion in the respiratory tracts of dog, monkey, and humans2016

    • Author(s)
      Koki Mitsumune, Kazuki Kuga, Sung-Jun Yoo and Kazuhide Ito
    • Organizer
      IAQVEC 2016
    • Place of Presentation
      South Korea
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PBPK-CSP-CFD Hybrid Analysis for Estimating Indoor Air Quality and Airway Tissue Dosimetry2016

    • Author(s)
      Sung-Jun Yoo and Kazuhide Ito
    • Organizer
      IAQVEC 2016
    • Place of Presentation
      South Korea
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Flow Visualization in a Realistic Replica a Model of Monkey Respiratory Tract using Particle Image Velocimetry2016

    • Author(s)
      Ji-Woong Kim, Kazuki Kuga, Shin-ichiro Aramaki, Nguyen Lu Phuong, and Kazuhide Ito
    • Organizer
      IAQVEC 2016
    • Place of Presentation
      South Korea
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Numerical Prediction of Airway Tissue Dosimetry using PBPK-CFD Hybrid Model integrated into Computer Simulated Person2016

    • Author(s)
      Sung-Jun Yoo and Kazuhide Ito
    • Organizer
      Indoor Air 2016, The 14th International Conference on Indoor Air Quality and Climate
    • Place of Presentation
      Belgium
    • Year and Date
      2016-07-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Numerical Prediction of Contaminant Distributions in Human Respiratory Tract for Exposure Assessment to E-Cigarettes2016

    • Author(s)
      Kazuki Kuga, Toshiki Matsuo, Sung-Jun Yoo, Kazuhide Ito, Wenhao Chen, Ping Wang, Jiawen Liao, Jeff Fowles, Dennis Shusterman, Kazukiyo Kumagai
    • Organizer
      Indoor Air 2016, The 14th International Conference on Indoor Air Quality and Climate
    • Place of Presentation
      Belgium
    • Year and Date
      2016-07-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dynamic downscaling analysis of air quality from urban to human scale: Part 1 Integration of WRF and CFD to predict wind pressure coefficient distribution2016

    • Author(s)
      Yusuke Sano, Alicia Murga, Yoichi Kawamoto, Kazuhide Ito
    • Organizer
      Indoor Air 2016, The 14th International Conference on Indoor Air Quality and Climate
    • Place of Presentation
      Belgium
    • Year and Date
      2016-07-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dynamic downscaling analysis of air quality from urban to human scale: Part 2 Exposure concentration analysis in a Large Factory Space2016

    • Author(s)
      Alicia Murga, Yusuke Sano, Yoichi Kawamoto, Kazuhide Ito
    • Organizer
      Indoor Air 2016, The 14th International Conference on Indoor Air Quality and Climate
    • Place of Presentation
      Belgium
    • Year and Date
      2016-07-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Integrated CFD and hygrothermal transfer analysis in energy recovery ventilator2016

    • Author(s)
      Yuki Morinaga, Hajime Sotokawa, Keiji Kameishi and Kazuhide Ito
    • Organizer
      Indoor Air 2016, The 14th International Conference on Indoor Air Quality and Climate
    • Place of Presentation
      Belgium
    • Year and Date
      2016-07-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluating net escape probability distribution of contaminant from local point to exhaust outlet in indoor environment2016

    • Author(s)
      Eunsu Lim, Kazuhide Ito and Mats Sandberg
    • Organizer
      Indoor Air 2016, The 14th International Conference on Indoor Air Quality and Climate
    • Place of Presentation
      Belgium
    • Year and Date
      2016-07-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 呼吸器系詳細形状を再現したComputer Simulated Personの開発 (第3報)  代謝を考慮した非定常呼吸サイクルモデルの提案と数値人体モデルへの統合2016

    • Author(s)
      門田陽介,劉 城準,伊藤一秀
    • Organizer
      日本建築学会九州支部研究発表会・研究報告
    • Place of Presentation
      琉球大学
    • Year and Date
      2016-03-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] 呼吸器系詳細形状を再現したComputer Simulated Personの開発 (第2報) 室内濃度分布解析と連成した経気道暴露濃度予測2015

    • Author(s)
      劉 城準,伊藤一秀
    • Organizer
      空気調和衛生工学会講演論文集
    • Place of Presentation
      大阪大学
    • Year and Date
      2015-09-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 呼吸器系詳細形状を再現したComputer Simulated Personの開発 (第1報) 気道内熱・水分移動予測による人体熱モデルの改良2015

    • Author(s)
      劉 城準,伊藤一秀
    • Organizer
      日本建築学会大会学術講演梗概集
    • Place of Presentation
      東海大学
    • Year and Date
      2015-09-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] 室内熱・空気環境評価のためのComputer Simulated Person開発と経気道暴露濃度評価シミュレーション2015

    • Author(s)
      伊藤一秀,劉 城準
    • Organizer
      第49回空気調和・冷凍連合講演会
    • Place of Presentation
      東京海洋大学
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report
  • [Remarks] 九州大学 伊藤一秀研究室

    • Related Report
      2017 Annual Research Report
  • [Remarks] Ito Lab., Kyushu University

    • Related Report
      2016 Annual Research Report
  • [Remarks] 九州大学 伊藤研究室

    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2022-09-27  

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