| Project/Area Number |
15H04254
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Gunma University |
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Principal Investigator |
Hirai Hirokazu 群馬大学, 大学院医学系研究科, 教授 (70291086)
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| Co-Investigator(Renkei-kenkyūsha) |
HOSOI Nobutake 群馬大学, 大学院医学系研究科, 講師 (90543570)
KONNO Ayumu 群馬大学, 大学院医学系研究科, 講師 (40509048)
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| Research Collaborator |
MATSUZAKI Yasunori 群馬大学, 大学院医学系研究科, 助教 (50738200)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | 小脳 / プルキンエ細胞 / mGluR1 / 運動学習 / バクロフェン / 脊髄小脳失調症 / 運動失調 / AAVベクター / SCA1 / SCA3 / 運動記憶 / 脳神経疾患 / 遺伝子 / シグナル伝達 / 神経科学 / 生理学 / 脊髄小脳変性症 / ポリグルタミン病 / ロータロッド / パッチクランプ |
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| Outline of Final Research Achievements |
Decrease of several genes including transient receptor potential cation channel type 3 (TRPC3), inositol trisphosphate (IP3) receptor and Homer protein homolog 3 (HOMER3) were found in the cerebellum of spinocerebellar ataxia type 1 (SCA1) knock-in mouse. We identified retinoid-related orphan receptor α (RORα), which is a transcription factor that could regulate expression of those genes. Moreover, we found that a gene “X” is increased more than 3 times in SCA1 knock-in mice 3 h after treatment with baclofen and rotarod training. Since haploinsufficiency of the gene “X” is known to cause mental retardation, upregulation of the gene “X” may play a key role in baclofen-induced improvement of motor learning in SCA1 mice.
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