| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Outline of Final Research Achievements |
The synapse, a site of communication between two neurons, operates as a minimal functional unit that underlies a variety of cognitive functions including learning and memory. This study aims to investigate the molecular basis of synaptic regulation through a gene called, Arc, whose expression is regulated in turn by synaptic activities. Our analysis revealed that Arc is involved in for formation and maintenance of long-term memory as well as experience-dependent neural plasticity. Furthermore, we found that Arc-expressing neurons in the hippocampus play a critical role for retrieval of a month-old memory in mice. Our results suggest a fundamental role of Arc in cognitive function in the brain.
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