Mechanisms underlying astrocyte-synapse contact dynamics
| Project/Area Number |
15H04280
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurochemistry/Neuropharmacology
|
|---|
| Research Institution | Institute of Physical and Chemical Research |
|---|
Principal Investigator |
GODA YUKIKO 国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (40614897)
|
|---|
| Research Collaborator |
LETELLIER Mathieu
PARK Yun Kyun
CHATER Thomas
CHIPMAN Peter
GAUTAM Sunita
KAWAI Atsushi
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
|
|---|
| Keywords | シナプス強度 / シナプス可塑性 / アストロサイト / シナプス伝達 / 神経科学 / 細胞・組織 / synaptic transmission / astrocyte / synapse / hGFAP promoter |
|---|
| Outline of Final Research Achievements |
Towards the goal of characterizing the dynamic interaction between astrocytes and synapses and identifying the underlying molecular mechanisms, we first constructed astrocyte-specific probes and validated promoters for astrocyte-specific expression. We then estabished virus production and stereotactic injection system to enable astrocyte-specific molecular manipulation in acute hippocampal slice preparations. Furthermore, we explored the role for gap junctions, which had previously been implicated in affecting asrtocyte-synapse structural contacts, and identified a functional role for the connexins, the gap junction proteins, in controlling synaptic strength and plasticity.
|
Report
(4 results)
Research Products
(6 results)
