Analysis of implantaion process by using Sox17 heterozygous mouse
| Project/Area Number |
15H04282
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KANAI Masami 東京医科歯科大学, 統合研究機構, 教授 (70321883)
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| Co-Investigator(Kenkyū-buntansha) |
平手 良和 東京医科歯科大学, 統合研究機構, 講師 (70342839)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | 着床 / 不妊 / マウス / Sox17 / 着床不全 / 女性不妊 / 着床障害 |
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| Outline of Final Research Achievements |
Few basic and systematic research has been done for maternal implantation process of fertilized embryo which is considered to be the factor in the pregnancy failure. In this study, we have done the pathological analysis by using female Sox17 heterozygous mouse. From the result of microarray analysis using endometrial epithelium from female Sox17 heterozygous mouse, we have selected that the gene group in which the signal ratio was significantly decreased as compared with the wild type.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Sox17 is Essential for Proper Formation of the Marginal Zone of Extraembryonic Endoderm Adjacent to a Developing Mouse Placental Disk.2018
Author(s)
Igarashi Hitomi, Uemura Mami, Hiramatsu Ryuji, Hiramatsu Ryuto, Segami Saki, Pattarapanawan Montri, Hirate Yoshikazu Yoshimura Yuki, Hashimoto Haruo, Higashiyama Hiroki, Sumitomo Hiroyuki, Kurohmaru Masamichi, Saijoh Yukio, Suemizu Hiroshi, Kanai-Azuma Masami, Kanai Yoshiakira.
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Journal Title
Biology of Reproduction
Volume: -
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Embryonic cholecystitis and defective gallbladder contraction in the Sox17-haploinsufficient mouse model of biliary atresia.2017
Author(s)
Higashiyama H, Ozawa A, Sumitomo H, Uemura M, Fujino K, Igarashi H, Imaimatsu K, Tsunekawa N, Hirate Y, Kurohmaru M, Saijoh Y, Kanai-Azuma M, Kanai Y.
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Journal Title
Development
Volume: 144
Issue: 10
Pages: 1906-1917
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Embryonic cholecystitis and defective gallbladder contraction in the Sox17-haploinsufficient model of biliary atresia.2017
Author(s)
Higashiyama H, Ozawa A, Sumitomo H, Uemura M, Fujino K, Igarashi H, Imaimatsu K, Tsunekawa N, Hirate Y, Kurohmaru M, Saijoh Y, Kanai-Azuma M, Kanai Y.
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Journal Title
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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