| Project/Area Number |
15H04299
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
Suzuki Hiromu 札幌医科大学, 医学部, 教授 (20381254)
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| Co-Investigator(Kenkyū-buntansha) |
山本 英一郎 札幌医科大学, 医学部, 講師 (60567915)
甲斐 正広 札幌医科大学, 医学部, 講師 (80260777)
丸山 玲緒 札幌医科大学, 医学部, 研究員 (60607985)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Keywords | 大腸がん / エピゲノム / DNAメチル化 / 遺伝子変異 / 大腸腺腫 / 鋸歯状病変 / 診断マーカー / 癌 / ゲノム / 遺伝子 / 発現制御 / 表面型大腸腫瘍 / 細胞・組織 |
|---|
| Outline of Final Research Achievements |
Recent advances in the cancer genome study revealed molecular alterations in colorectal cancer (CRC). However, mechanisms underlying the colorectal tumorigenesis in pathways other than the conventional adenoma-carcinoma sequence are not fully understood. To address this issue, we focused on early colorectal lesions with superficial or laterally spreading morphologies and those in the serrated neoplastic pathway. Through performing genetic and epigenetic analysis in a large number of primary colorectal tumors, we identified NTSR1, DKGK, SMOC1 and ZNF582-AS1 as novel CRC-related genes. We found that methylation of NTSR1 is associated with lateral and noninvasive growth of colorectal tumors while methylation of SMOC1 is associated with the development of traditional serrated adenomas. Surface microstructures of early colorectal tumors are associated with genetic and epigenetic alterations, and are associated with the malignant potential.
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