| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
Spermatogenesis is the process to generate mature sperms through three steps: mitosis, meiosis, and spermiogenesis. Here we investigated a mechanism by which many essential genes to meiosis are transcriptionally activated by genome-wide analyses of histone modifications and transcripts as well as by the reporter gene assay and genome editing. We found that a multi-functional genomic element, dual promoter-enhancer (DPE), plays important roles in transcriptional activation during meiosis. In addition, we showed the involvement of long noncoding RNAs in this transcriptional regulation.
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