Development of high-efficiency gene targeting technologies
| Project/Area Number |
15H04323
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
System genome science
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| Research Institution | Yokohama City University |
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Principal Investigator |
Noritaka Adachi 横浜市立大学, 生命ナノシステム科学研究科(八景キャンパス), 教授 (30264675)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2015: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | ジーンターゲティング / ヒトゲノム / ゲノム編集 / DNA修復 / ゲノム修復 |
|---|
| Outline of Final Research Achievements |
In this research project, we have successfully identified a human protein that is essential for alternative end-joining, a minor pathway of DNA double-strand break repair. This discovery has led us to develop a unique system to suppress random integration of transfected DNA, making it possible to perform human cell gene targeting with 100% efficiency.
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Report
(4 results)
Research Products
(9 results)
