Mechanistic insight into how the autophagosomes form and searching for the drug regulating autophagy
| Project/Area Number |
15H04371
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Osaka University |
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Principal Investigator |
Hamasaki Maho 大阪大学, 生命機能研究科, 准教授 (30455216)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | オートファジー / 小胞体 / ミトコンドリア / 薬剤スクリーニング / コンタクトサイト / 膜動態 / EM / メントラ |
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| Outline of Final Research Achievements |
Autophagy, found by Dr. Ohsumi who won the 2016 Nobel Prize in Physiology or Medicine, is a cellular degradation system that can be induced by stress such as starvation. When cells are starved, part of cytosol and organelles are degraded and recycles to survive by forming organelles called "autophagosomes". Autophagosomes have a diameter of 1um and do not always exist in the cell, they forms when degradation is required. It has been over 20 years since autophagy related genes were identified yet how the autophagosomes are formed is unclear. Aim of this research is to characterize how the autohpagosome forms in detail.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Ubiquitination of exposed glycoproteins by SCFFBXO27 directs damaged lysosomes for autophagy.2017
Author(s)
Yoshida Y, Yasuda S, Fujita T, Hamasaki M, Murakami A, Kawawaki J, Iwai K, Saeki Y, Yoshimori T, Matsuda N, Tanaka K
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 114
Issue: 32
Pages: 8574-8579
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice.2016
Author(s)
Tanaka S, Hikita H, Tatsumi T, Sakamori R, Nozaki Y, Sakane S, Shiode Y, Nakabori T, Saito Y, Hiramatsu N, Tabata K, Kawabata T, Hamasaki M, Eguchi H, Nagano H, Yoshimori T, Takehara T.
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Journal Title
Hepatology
Volume: 64
Issue: 6
Pages: 1994-2014
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Mitochondrial division occurs concurrently with autophagosome formation but independently of Drp1 during mitophagy.2016
Author(s)
Yamashita SI, Jin X, Furukawa K, Hamasaki M, Nezu A, Otera H, Saigusa T, Yoshimori T, Sakai Y, Mihara K, Kanki T.
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Journal Title
J Cell Biol.
Volume: 215
Issue: 5
Pages: 649-665
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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