The mechanism for the positioning of cell nucleus at the cell center
| Project/Area Number |
15H04372
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
Kimura Akatsuki 国立遺伝学研究所, 構造遺伝学研究センター, 教授 (10365447)
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| Co-Investigator(Renkei-kenkyūsha) |
GODA Makoto 浜松医科大学, 光尖端医学教育研究センター, 研究技術職員 (70442960)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Keywords | 細胞核 / 線虫 / 微小管 / 力 / 細胞骨格 / 棘皮動物（ウニ） |
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| Outline of Final Research Achievements |
In many cell types, the cell nucleus is positioned at the center of the cell. The mechanism to position the nucleus at the cell center is still under debate. In this research project, we obtained results to support ‘cytoplasmic pulling model’, in which the nucleus moves toward the cell center by the pulling force produced throughout the cytoplasm. Moreover, we have succeeded to measure the forces required to move the nucleus in a living cell. These achievements advanced the mechanism for the positioning of cell nucleus at the cell center.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Endoplasmic Reticulum-Mediated Microtubule Alignment Governs Cytoplasmic Streaming2017
Author(s)
Kenji Kimura, Alexandre Mamane, Tohru Sasaki, Kohta Sato, Jun Takagi, Ritsuya Niwayama, Lars Hufnagel, Yuta Shimamoto, Jean-Francois Joanny, Seiichi Uchida, and Akatsuki Kimura
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Journal Title
Nature Cell Biology
Volume: 19
Issue: 4
Pages: 399-406
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] A genetically encoded probe for live-cell imaging of H4K20 monomethylation2016
Author(s)
Sato Y., Kujirai T., Arai R., Asakawa H., Ohtsuki C., Horikoshi N., Yamagata K., Ueda J., Nagase T., Haraguchi T., Hiraoka Y., Kimura A., Kurumizaka H., Kimura, H.
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Journal Title
J. Mol. Biol.
Volume: 428
Issue: 20
Pages: 3885-3902
DOI
Related Report
Peer Reviewed / Open Access
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