Regulation by orexigenic and anorexigenic neuropeptides of emotional behavior in fish
| Project/Area Number |
15H04394
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | University of Toyama |
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Principal Investigator |
Matsuda Kouhei 富山大学, 大学院理工学研究部(理学), 教授 (60222303)
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| Co-Investigator(Kenkyū-buntansha) |
中町 智哉 富山大学, 大学院理工学研究部(理学), 助教 (30433840)
今野 紀文 富山大学, 大学院理工学研究部(理学), 講師 (50507051)
吉田 将之 広島大学, 生物圏科学研究科, 准教授 (70253119)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Keywords | ゼブラフィッシュ / 情動行動 / キンギョ / メダカ / 摂食行動 / 神経基盤 / 遺伝子改変魚種 / ウシガエル幼生 / 神経ペプチド |
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| Outline of Final Research Achievements |
Our previous studies have indicated that intracerebroventricular (ICV) administration of several neuropeptides related to feeding regulation affect psychomotor activity in fish. Therefore, we examined the effect of ICV injection of neuropeptides such as cholecystokinin and pituitary adenylate cyclase-activating polypeptide (PACAP) on emotional behavior including anxiety-like behavior in fish. ICV administration of neuropeptides mentioned above induced anxiety-like behavior in fish. In addition, we prepared transgenic fish (including vasotosine, PACAP and mineralocorticoid-receptor knock out fish), and observed swimming behavior. The results suggested that psychomotor activity is affected by hormones- and their receptors-knock out.
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Report
(4 results)
Research Products
(88 results)
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[Journal Article] Imorin: a sexual attractiveness pheromone in female red-bellied newts (Cynops pyrrhogaster).2017
Author(s)
Nakada, T., Toyoda, F., Matsuda, K., Nakakura, T., Hasunuma, I., Yamamoto, K., Onoue, S., Yokosuka, M. and Kikuyama, S.
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Journal Title
Scientific Reports
Volume: -
Issue: 1
Pages: 41334-41334
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Principal function of mineralocorticoid signaling suggested by constitutive knockout of the mineralocorticoid receptor in medaka fish.2016
Author(s)
Sakamoto, T., Yoshiki, M., Takahashi, H., Yoshida, M., Ogino, Y., Ikeuchi, T., Nakamachi, T., Konno, N., Matsuda, K. and Sakamoto, H.
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Journal Title
Scientific Reports
Volume: -
Issue: 1
Pages: 37991-37991
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Impact of dehydration on the forebrain preoptic recess walls in the mudskipper, Periophthalmus modestus: a possible locus for the center of thirst.2016
Author(s)
Hamasaki, S., Mukuda, T.*, Kaidoh, T., Yoshida, M., Uematsu, K.
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Journal Title
Journal of Comparative Physiology-B
Volume: 186
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] PACAP suppresses dry eye signs by stimulating tear secretion.2016
Author(s)
Nakamachi T, Ohtaki H, Seki T, Yofu S, Kagami N, Hashimoto H, Shintani N, Baba A, Mark L, Lanekoff I, Kiss P, Farkas J, Reglodi D, Shioda S.
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Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Two zebrafish G2A homologs activate multiple intracellular signaling pathways in acidic environment.2016
Author(s)
Y. Ichijo, Y. Mochimaru, M. Azuma, K. Satou, J. Negishi, T. Nakakura, N. Oshima, C. Mogi, K. Sato, K. Matsuda, F. Okajima, H. Tomura
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Journal Title
Biochem. Biophys. Res. Commun.
Volume: 469
Issue: 1
Pages: 81-86
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Is Involved in Adult Mouse Hippocampal Neurogenesis After Stroke2016
Author(s)
Matsumoto, M., Nakamachi, T., Watanabe, J., Sugiyama, K., Ohtaki, H., Murai, N., Sasaki, S., Xu, Z., Hashimoto, H., Seki, T., Miyazaki, A., and Shioda, S.
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Journal Title
Journal of Molecular Neuroscience
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Urotensin II upregulates migration and cytokine gene expression in leukocytes of the African clawed frog, Xenopus laevis.2015
Author(s)
Tomiyama, S., Nakamachi, T., Uchiyama, M., Matsuda, K., and Konno, N.
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Journal Title
Gen. Comp. Endocrinol.
Volume: in press
Pages: 54-63
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Morphological and molecular investigations of the holocephalan elephant fish nephron: the existence of a countercurrent-like configuration and two separate diluting segments in the distal tubule.2015
Author(s)
Kakumura, K., Takabe, S., Takagi, W., Hasegawa, K., Konno, N., Bell, J., Toop, T., Donald, J., Kaneko, T., and Hyodo, S.
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Journal Title
Cell and Tissue Research
Volume: 362
Issue: 3
Pages: 677-688
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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