Physiological polymorphism on Wnt signal and bone-vessel association

• Project/Area Number: 15H04432
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied anthropology
• Research Institution: Nagasaki University
• Principal Investigator: AOYAGI Kiyoshi 長崎大学, 医歯薬学総合研究科(医学系), 教授 (80295071)
• Co-Investigator(Kenkyū-buntansha): 有馬 和彦 長崎大学, 医歯薬学総合研究科(医学系), 講師 (30423635) ; 前田 隆浩 長崎大学, 医歯薬学総合研究科(医学系), 教授 (40284674) ; 西村 貴孝 長崎大学, 医歯薬学総合研究科(医学系), 助教 (80713148) ; 安部 恵代 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (90372771) ; 富田 義人 長崎大学, 医歯薬学総合研究科(医学系), 助教 (40779584)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000); Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
• Keywords: 生理的多型性 / 骨粗鬆症 / 動脈硬化 / 骨・血管連関 / 骨量 / スクレロスチン / 動脈硬化症

Outline of Final Research Achievements

We aimed to clear the effect of sclerostin adjusting Wnt signal to the association between bone and blood vessel. The subjects were community-dwelling men (n=446) and women (n=689), and their bone mass and index of arteriosclerosis were measured. In results, after adjusting confounding factors, a higher level of sclerostin was significantly correlated with a higher bone mass in both sexes, and a higher bone mass was significantly correlated with a higher index of arteriosclerosis.

Academic Significance and Societal Importance of the Research Achievements

男女ともにスクレロスチンと骨量は正の関連を示したが、その関連は男性のほうがやや強い関連を示した。一方で、先行研究とは異なり、スクレロスチンと動脈硬化指数に有意な関連はなかった。本研究は、骨・血管連関の生理的多型性をWntシグナルのメカニズムを通して解明を試みたものであり、人類学的に意義がある。

Research Products

• [Journal Article] Relationship between bone turnover markers and the heel stiffness index measured by quantitative ultrasound in middle-aged and elderly Japanese men (2018)
  • Author(s): Nishimura Takayuki、Arima Kazuhiko、Abe Yasuyo、Kanagae Mitsuo、Mizukami Satoshi、Okabe Takuhiro、Tomita Yoshihito、Goto Hisashi、Horiguchi Itsuko、Aoyagi Kiyoshi
  • Journal Title: Medicine Volume: 97 Issue: 8 Pages: e9962-e9962
  • DOI: 10.1097/md.0000000000009962
  • NAID: 120006987315
  • Peer Reviewed / Open Access
• [Journal Article] Prevalence of fear of falling and associated factors among Japanese community-dwelling older adults (2018)
  • Author(s): Tomita Yoshihito、Arima Kazuhiko、Tsujimoto Ritsu、Kawashiri Shin-ya、Nishimura Takayuki、Mizukami Satoshi、Okabe Takuhiro、Tanaka Natsumi、Honda Yuzo、Izutsu Kazumi、Yamamoto Naoko、Ohmachi Izumi、Kanagae Mitsuo、Abe Yasuyo、Aoyagi Kiyoshi
  • Journal Title: Medicine Volume: 97 Issue: 4 Pages: e9721-e9721
  • DOI: 10.1097/md.0000000000009721
  • Peer Reviewed / Open Access
• [Journal Article] Association of vertebral compression fractures with physical performance measures among community-dwelling Japanese women aged 40 years and older. (2017)
  • Author(s): Arima K, Abe Y, Nishimura T, Okabe T, Tomita Y, Mizukami S, Kanagae M, Aoyagi K.
  • Journal Title: BMC Musculoskelet Disord Volume: 18 Issue: 1 Pages: 176-176
  • DOI: 10.1186/s12891-017-1531-3
  • NAID: 120006987518
  • Peer Reviewed / Open Access
• [Journal Article] Age-specific risk factors for incident disability in activities of daily living among middle-aged and elderly community-dwelling Japanese women during an 8-9-year follow up: The Hizen-Oshima study. (2017)
  • Author(s): Okabe T, Abe Y, Tomita Y, Mizukami S, Kanagae M, Arima K, Nishimura T, Tsujimoto R, Tanaka N, Goto H, Horiguchi I, Aoyagi K.
  • Journal Title: Geriatr Gerontol Int. Volume: 17 Issue: 7 Pages: 1096-1101
  • DOI: 10.1111/ggi.12834
  • Peer Reviewed
• [Journal Article] Effect of self-reported walking difficulty on bone mass and bone resorption marker in Japanese people aged 40 years and over (2016)
  • Author(s): Abe Y, Nishimura T, Arima K, Kanagae M, Mizukami S, Tomita Y, Okabe T, Goto H, Horiguchi I, Aoyagi K
  • Journal Title: J Physiol Anthropol Volume: 35 Issue: 1 Pages: 25-25
  • DOI: 10.1186/s40101-016-0114-6
  • NAID: 120006987448
  • Peer Reviewed / Open Access
• [Journal Article] Prevalence of lumbar spondylosis and its association with low back pain among community-dwelling Japanese women (2016)
  • Author(s): Tsujimoto R, Abe Y, Arima K, Nishimura T, Tomita M, Yonekura A, Miyamoto T, Matsubayashi S, Tanaka N, Aoyagi K
  • Journal Title: BMC Musculoskelet Disord Volume: 17 Issue: 1 Pages: 493-493
  • DOI: 10.1186/s12891-016-1343-x
  • NAID: 120006987612
  • Peer Reviewed / Open Access
• [Journal Article] Relationship Between Urinary Cross-Linked N-Telopeptide of Type-I Collagen and Heel Stiffness Index Measured by Quantitative Ultrasound in Middle-Aged and Elderly Men (2015)
  • Author(s): Nishimura T, Arima K, Abe Y, Kanagae M, Mizukami S, Okabe T, Tomita Y, Goto H, Horiguchi I, Aoyagi K
  • Journal Title: Medicine Volume: 94 Issue: 44 Pages: 1797-1797
  • DOI: 10.1097/md.0000000000001797
  • Peer Reviewed
• [Journal Article] Association of Physical Performance and Pain With Fear of Falling Among Community-Dwelling Japanese Women Aged 65 Years and Older (2015)
  • Author(s): Tomita Y, Arima K, Kanagae M, Okabe T, Mizukami S, Nishimura T, Abe Y, Goto H, Horiguchi I, Aoyagi K
  • Journal Title: Medicine Volume: 94 Issue: 35 Pages: 1449-1449
  • DOI: 10.1097/md.0000000000001449
  • NAID: 120006986851
  • Peer Reviewed
• [Presentation] Association of Physical Performance and Pain With Fear of Falling Among Community-Dwelling Japanese Women Aged 65 Years and Older. (2018)
  • Author(s): Yoshihito Tomita, Kazuhiko Arima, Mitsuo Kanagae, Takuhiro Okabe, Satoshi Mizukami, Takayuki Nishimura, Yasuyo Abe, Hisashi Goto, Itsuko Horiguchi, Kiyoshi Aoyagi
  • Organizer: International Symposium on Physiological Anthropology (ISPA) , Kota Kinabalu, Malaysia,
  • Int'l Joint Research
• [Presentation] Prevalence of fear of falling and associated factors among Japanese community-dwelling older adults (2018)
  • Author(s): Tomita Y, Arima K, Tsujimoto R, Kawashiri S, Nishimura T, Mizukami S, Okabe T, Tanaka N, Honda Y, Izutsu K, Yamamoto N, Ohmachi I, Kanagae M, Abe Y, Aoyagi K
  • Organizer: International Scientific Seminar Physiological Anthropology and Human Ecology, Moscow, Russia,
  • Int'l Joint Research
• [Presentation] Moderate drinking alcohol is associate with higher bone mass in Japanese community dwelling population (2018)
  • Author(s): Kazuhiko Arima, Takayuki Nishimura, Yoshihito Tomita, Shoichi Fukui, Naoki Iwamoto, Shin-ya Kawashiri, Mami Tamai, Yasuyo Abe, Atsushi Kawakami, Kiyoshi Aoyagi
  • Organizer: the 20th Asia Pacific League of Associations for Rheumatology Congress (APLAR 2018), Kaohsiung, Taiwan
  • Int'l Joint Research
• [Presentation] 骨量関連因子の解析 長崎アイランドコホート研究骨衛生活動． (2018)
  • Author(s): 有馬 和彦, 岩本 直樹, 福井 翔一, 川尻 真也, 玉井 慎美, 川上 純, 青柳 潔
  • Organizer: 日本リウマチ学会総会・学術集会プログラム・抄録集62回（東京）
• [Presentation] 閉経後女性における主観的歩行速度と骨量との関連 (2018)
  • Author(s): 富田義人，有馬和彦，西村貴孝，岡部拓大，水上諭，金ケ江光生，安部恵代，本井碧，小屋松淳，山梨啓友，清水悠路，前田隆浩，青柳 潔
  • Organizer: 日本生理人類学会誌第78回大会概要集（東京）
• [Presentation] 地域在住住民における飲酒習慣と骨量の関連解析 (2018)
  • Author(s): 有馬 和彦, 富田 義人, 西村 貴孝, 岡部 拓大, 水上 諭, 金ヶ江 光生, キット 彩乃, 長谷川 麻衣子, 宗 陽子, 後藤 尚, 安部 恵代, 青柳 潔
  • Organizer: 第77回日本公衆衛生学会総会抄録集（福島）
• [Presentation] 地域在住高齢者における転倒恐怖感の関連要因 (2018)
  • Author(s): 富田 義人, 岡部 拓大, 水上 諭, 金ヶ江 光生, キット 彩乃, 長谷川 麻衣子, 宗 陽子, 後藤 尚, 西村 貴孝, 有馬 和彦, 安部 恵代, 青柳 潔
  • Organizer: 第77回日本公衆衛生学会総会抄録集（福島）
• [Presentation] 中年および高齢女性における低骨量と転倒・転倒恐怖感との関連 (2017)
  • Author(s): 富田 義人, 有馬 和彦, 西村 貴孝, 金ヶ江 光生, 安部 恵代, 青柳 潔
  • Organizer: 日本骨粗鬆症学会
• [Presentation] 地域在住中高年者における低カルボキシル化オステオカルシンと骨量との関連 (2017)
  • Author(s): 田中 奈津美, 有馬 和彦, 西村 貴孝, 富田 義人, 安部 恵代, 尾崎 誠, 青柳 潔
  • Organizer: 日本骨粗鬆症学会
• [Presentation] 地域在住高齢者における転倒恐怖感の関連要因 (2016)
  • Author(s): 富田義人，西村貴孝，岡部拓大，水上 諭，金ケ江光生，有馬和彦，安部恵代，後藤 尚，青柳 潔
  • Organizer: 第75回日本公衆衛生学会総会
  • Place of Presentation: グランフロント大阪（大阪府・大阪市）
  • Year and Date: 2016-10-28
• [Presentation] 長崎県農村地域の中高年男性における骨量と骨代謝マーカーとの関連 (2016)
  • Author(s): 西村貴孝，有馬和彦，安部恵代，青柳 潔
  • Organizer: 第26回九州農村医学会
  • Place of Presentation: 沖縄県男女共同参画センターてぃるる(沖縄県・那覇市）
  • Year and Date: 2016-07-02
• [Presentation] Association of spinal inclination and vertebral deformities with difficulties in activities of daily living (2015)
  • Author(s): Abe Y, Aoyagi K
  • Organizer: ASBMR annual meeting
  • Place of Presentation: Seattle, Washington, USA
  • Year and Date: 2015-10-09
  • Int'l Joint Research
• [Presentation] 地域侍従中高年女性における新規非椎体骨折 (2015)
  • Author(s): 安部恵代、松下雄太、西村貴孝、有馬和彦、青柳潔
  • Organizer: 第17回日本骨粗鬆症学会
  • Place of Presentation: 広島国際会議場（広島県・広島市）
  • Year and Date: 2015-09-17
• [Presentation] 地域在住中高年者における骨量と骨代謝マーカー及び生活習慣との関連 (2015)
  • Author(s): 西村貴孝、有馬和彦、安部恵代、青柳潔
  • Organizer: 日本生理人類学会第72回大会
  • Place of Presentation: 北海道大学医学部学友会館「フラテ」（北海道・札幌市）
  • Year and Date: 2015-05-30
• [Remarks] 長崎大学大学院医歯薬学総合研究科公衆衛生学
  • URL: http://www.med.nagasaki-u.ac.jp/public-h/