| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2017: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Outline of Final Research Achievements |
It is essential to develop a new chemical synthesis method that can convert peptide related substances into precisely designed structures including the stereochemistry required for the expression of activity. In this study, a novel peptide molecular cyclization method and intramolecular crosslinking formation control method are established, preconditionally controlled with three or more pairs of crosslinks at arbitrary positions in the molecule, using Conotoxin as a model. In addition, it was aimed to establish a novel chemical synthesis method capable of obtaining a peptide with high purity and high yield. As a result, we developed a new method to relax the rigid structure (conformation) of the chain peptide which interferes with the ring-forming reaction and remove the barrier of intramolecular crosslinking derived from the rigid conformation of the peptide. Based on these results, it was succeeded in developing a precise control method of a new three-dimensional structure.
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